Collaborative Research Training in Thrombosis and Inflammation

血栓和炎症合作研究培训

• 批准号: 9983169
• 负责人: Miguel Angel Cruz
• 金额: $ 34.44万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9983169
• 关键词: Inflammation; Research Training; Thrombosis

This new T32 program will prepare postdoctoral trainees for collaborative research careers in two inter-related topics: thrombosis and inflammation. There is increasing evidence of a direct relationship between thrombosis and inflammation in numerous human diseases. As examples, inflammation contributes to the pathogenesis of thrombotic disorders such as stroke and coronary artery disease, while thrombosis influences disease severity in conditions associated with inflammation including sepsis, autoimmune diseases and cancer. While thrombosis and inflammation frequently coexist, to our knowledge, this will be the only T32 program in the nation with a primary focus on both processes. The Center for Translational Research on Inflammatory Diseases (CTRID) at Michael E. DeBakey VA Medical Center and the Division of Thrombosis Research at Baylor College of Medicine will sponsor this collaborative training program with rigorous research opportunities and close mentoring by faculty. The group of 17 faculty mentors includes 14 NIH-funded investigators and 6 VA Merit-funded investigators; 12 of the mentors are physician-scientists and the balance non-physician scientists. The major strengths of our program include: 1) a cohesive and highly collaborative group of successful mentors with research expertise in relevant topics for our program, including platelets, neutrophils, microvascular thrombosis, stroke, cancer, sepsis, inflammatory conditions in kidney, lung, and bone, among others; 2) a unique combined curriculum with shared didactic and clinically- oriented training for physician and non-physician trainees; and 3) it is based in a thriving research center committed to mentoring, including a weekly seminar series that consists of > 60% speakers with scientific interests aligned with the themes of this T32. In addition to training physician-scientists in biomedical research, PhD scientists will be trained in translational medicine offering a direct interaction with patients with clinical conditions related to the focus of this T32. PhD trainees will be paired with physician trainees during these clinical practicums; this collaborative aspect of the program will teach PhD postdoctoral fellows the importance and benefit of conducting research in collaboration with physician-scientists and vice-versa. The program consists of 2-3 years of research training, enriched by didactic courses, an outstanding seminar series and a vibrant scientific environment. Successful implementation of this T32 in Thrombosis and Inflammation will pave the way for new biological insights and novel ways of prevention and treatment of thrombotic-inflammatory disorders by educating future physician- and non-physician scientists for collaborative research careers in thrombosis and inflammation.

这个新的T32计划将为博士后培训生的合作研究生涯做好准备， 两个相互关联的主题：血栓形成和炎症。越来越多的证据表明， 血栓形成和炎症在许多人类疾病中的关系。例如， 炎症有助于血栓性疾病如中风的发病机制， 冠状动脉疾病，而血栓形成影响疾病的严重程度， 炎症包括败血症自身免疫性疾病和癌症虽然血栓形成和 炎症频繁共存，据我们所知，这将是全国唯一的T32项目 主要关注这两个过程。炎症转化研究中心（Center for Translational Research on Inflammatory 疾病（CTRID）在迈克尔E。DeBakey VA医疗中心和血栓形成部门 贝勒医学院的研究将赞助这一合作培训计划， 严格的研究机会和教师的密切指导。17名教师导师组成的小组 包括14名NIH资助的研究人员和6名VA Merit资助的研究人员; 12名导师是 医生科学家和平衡非医生科学家。我们的主要优势 计划包括：1）一个成功的导师组成的具有凝聚力和高度协作性的团队， 在我们的计划相关主题的研究专业知识，包括血小板，中性粒细胞， 微血管血栓形成、中风、癌症、脓毒症、肾、肺和 骨，除其他外; 2）一个独特的综合课程与共享的教学和临床- 面向医生和非医生学员的培训;和3）它是基于一个蓬勃发展的 研究中心致力于指导，包括每周研讨会系列，包括> 60%的演讲者具有与T32主题一致的科学兴趣。除了培训 生物医学研究的医生科学家，博士科学家将接受翻译培训， 医学提供了一个直接的互动与患者的临床条件有关的重点， 这个T32在这些临床实习期间，博士学员将与医生学员配对;这 该计划的合作方面将教博士博士后研究员的重要性， 与医生-科学家合作进行研究的好处，反之亦然。的 该计划包括2-3年的研究培训，通过教学课程丰富，一个杰出的 研讨会系列和充满活力的科学环境。T32的成功实施， 血栓形成和炎症将为新的生物学见解和新的治疗方法铺平道路。 通过培养未来的医生预防和治疗血栓炎性疾病- 和非医生的科学家在血栓形成和炎症的合作研究事业。