Collaborative Research Training in Thrombosis and Inflammation

血栓和炎症合作研究培训

• 批准号: 9983169
• 负责人: Miguel Angel Cruz
• 金额: $ 34.44万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9983169
• 关键词: Inflammation; Research Training; Thrombosis

This new T32 program will prepare postdoctoral trainees for collaborative research careers in two inter-related topics: thrombosis and inflammation. There is increasing evidence of a direct relationship between thrombosis and inflammation in numerous human diseases. As examples, inflammation contributes to the pathogenesis of thrombotic disorders such as stroke and coronary artery disease, while thrombosis influences disease severity in conditions associated with inflammation including sepsis, autoimmune diseases and cancer. While thrombosis and inflammation frequently coexist, to our knowledge, this will be the only T32 program in the nation with a primary focus on both processes. The Center for Translational Research on Inflammatory Diseases (CTRID) at Michael E. DeBakey VA Medical Center and the Division of Thrombosis Research at Baylor College of Medicine will sponsor this collaborative training program with rigorous research opportunities and close mentoring by faculty. The group of 17 faculty mentors includes 14 NIH-funded investigators and 6 VA Merit-funded investigators; 12 of the mentors are physician-scientists and the balance non-physician scientists. The major strengths of our program include: 1) a cohesive and highly collaborative group of successful mentors with research expertise in relevant topics for our program, including platelets, neutrophils, microvascular thrombosis, stroke, cancer, sepsis, inflammatory conditions in kidney, lung, and bone, among others; 2) a unique combined curriculum with shared didactic and clinically- oriented training for physician and non-physician trainees; and 3) it is based in a thriving research center committed to mentoring, including a weekly seminar series that consists of > 60% speakers with scientific interests aligned with the themes of this T32. In addition to training physician-scientists in biomedical research, PhD scientists will be trained in translational medicine offering a direct interaction with patients with clinical conditions related to the focus of this T32. PhD trainees will be paired with physician trainees during these clinical practicums; this collaborative aspect of the program will teach PhD postdoctoral fellows the importance and benefit of conducting research in collaboration with physician-scientists and vice-versa. The program consists of 2-3 years of research training, enriched by didactic courses, an outstanding seminar series and a vibrant scientific environment. Successful implementation of this T32 in Thrombosis and Inflammation will pave the way for new biological insights and novel ways of prevention and treatment of thrombotic-inflammatory disorders by educating future physician- and non-physician scientists for collaborative research careers in thrombosis and inflammation.

这一新的T32项目将为博士后实习生在 两个相互关联的话题：血栓形成和炎症。越来越多的证据表明， 多种人类疾病中血栓形成与炎症的关系。举个例子， 炎症在血栓性疾病的发病机制中起作用，如中风和 冠状动脉疾病，而血栓形成在相关条件下影响疾病严重程度 炎症包括败血症、自身免疫性疾病和癌症。当血栓形成和 炎症频繁并存，据我们所知，这将是全国唯一的T32节目 主要集中在这两个过程上。炎症性疾病翻译研究中心 Michael E.DeBakey VA医学中心和血栓科的疾病(CTRID) 贝勒医学院的研究将赞助这一合作培训计划 严谨的研究机会和教职员工的密切指导。由17名教师导师组成的小组 包括14名由NIH资助的调查人员和6名由退伍军人事务部资助的调查人员；其中12名导师是 内科科学家和非内科科学家的天平。我们的主要优势是 计划包括：1)具有凝聚力和高度协作性的成功导师团队 我们项目相关课题的研究专长，包括血小板，中性粒细胞， 微血管血栓形成、中风、癌症、脓毒症、肾、肺和 骨等；2)独特的组合课程，共享教学和临床- 对医生和非医生实习生进行定向培训；3)立足于蓬勃发展的 致力于指导的研究中心，包括每周一次的研讨会系列，由&GT； 60%具有科学兴趣的演讲者与本T32的主题保持一致。除了培训之外 生物医学研究方面的医生-科学家，博士科学家将接受翻译培训 提供与患者直接互动的医学与与焦点相关的临床情况 这是T32。在这些临床实习期间，博士实习生将与医生实习生配对； 该项目的合作方面将向博士后研究员传授重要性和 与内科科学家合作进行研究的好处，反之亦然。这个 计划包括2-3年的研究性培训，丰富了教学课程，是一个杰出的 系列研讨会和充满活力的科学环境。此T32在以下方面成功实施 血栓和炎症将为新的生物学见解和新的治疗方法铺平道路 通过培养未来的医生预防和治疗血栓性炎症性疾病-- 和非内科科学家在血栓形成和炎症方面的合作研究生涯。