ICAL: Impact of Cannabinoids Across Lifespan: Administrative Core

项目摘要：行政核心 我们建议建立一个NIDA卓越中心，研究大麻的影响 寿命(Ical)，以检验内源性大麻素的非生理性激活的假设 青春期系统--因接触D9-四氢大麻酚(THC)或其一种而引起 合成模拟物-启动控制遗传和表观遗传过程的重新编程 这个系统的分子结构、神经解剖结构和突触功能，最终 在认知和动机行为上产生持续的异常。为了检验这一假设， ICAL将部署一种垂直整合的战略，将分子、神经解剖学、 电生理学和行为学方法。行政核心将作为 所有科学和方案活动的组织中心。这个核心的总体目标是 将集中这些活动，同时提高业务效率和透明度 临床研究人员、实习生和工作人员。行政核心的科学领导将监督 并整合了ICI的三个研究项目的活动，两个共享研究核心，试点核心， 和外展活动。核心主任Daniele Piomelli是 解剖学和神经生物学、生物化学和药理学，路易丝·特纳·阿诺德教授 他还是新成立的加州大学洛杉矶分校大麻研究所的主任。 核心联席主任马塞洛·伍德是神经生物学和神经学系的教授和主任。 他也是欧文成瘾神经科学中心的主任。皮奥梅利博士和伍德博士将 利用UCI神经科学界杰出成员的专业知识组成 中心的内部指导委员会(SC)。此外，他们还将组建一个外部咨询机构 由神经科学和大麻素研究领域的领军人物组成的小组(EAG)。这个 总监和联席总监将与经验丰富的项目专家合作开发系统和 管理工作流程，协调会议，促进与ICAL SC和EAG的互动 和其他利益攸关方，跟踪和报告中心的进展，确定挑战并实施 解决办法。项目专家将负责预算管理和报告， 起草和维护动物协议，为ICAL的网站和其他网站生成内容 通信，并协调和安排所有会议、双月研讨会、 国际讲习班和外联活动。行政部门的综合专业知识 CORE的领导层和工作人员将确保实现ICIC的科学和计划目标，并 以一种有影响力的方式传播给大麻素研究人员以及整个科学 社区和广大公众。

PROJECT SUMMARY: ADMINISTRATIVE CORE We propose the creation of a NIDA Center of Excellence, Impact of Cannabinoids Across the Lifespan (ICAL), to test the hypothesis that non-physiological activation of the endocannabinoid system in adolescence – caused by exposure to D9-tetrahydrocannabinol (THC) or one of its synthetic mimics – initiates a reprogramming of the genetic and epigenetic processes that govern this system’s molecular structure, neuroanatomical architecture, and synaptic functions, ultimately producing persistent abnormalities in cognition and motivated behavior. To test this hypothesis, ICAL will deploy a vertically integrated strategy combining molecular, neuroanatomical, electrophysiological, and behavioral approaches. The Administrative Core will serve as the organizational hub for all ICAL’s scientific and programmatic activities. The overall goal of this core will be to centralize these activities while promoting efficiency in operations and transparency for ICAL investigators, trainees, and staff. The Administrative Core’s scientific leadership will oversee and integrate the activities of ICAL’s three research projects, two shared research cores, pilot core, and outreach activities. The core director, Daniele Piomelli is Professor in the Departments of Anatomy & Neurobiology, Biological Chemistry and Pharmacology, the Louise Turner Arnold Chair in the Neurosciences, and director of the newly created UCI Institute for the Study of Cannabis. The core co-director, Marcelo Wood, is Professor and Chair in the Department of Neurobiology & Behavior, and director of the Irvine Center for Addiction Neuroscience. Drs. Piomelli and Wood will leverage the expertise of distinguished members of UCI’s neuroscience community to form the Center’s internal Steering Committee (SC). In addition, they will assemble an External Advisory Group (EAG) composed of leaders in the field of neuroscience and cannabinoid research. The director and co-director will work with an experienced Program Specialist to develop systems and processes to manage workflow, coordinate meetings, facilitate interaction with ICAL’s SC and EAG and other stakeholders, track and report the Center’s progress, identify challenges and implement solutions. The Program Specialist will be responsible for budget management and reporting, drafting and maintaining of animal protocols, generating content for ICAL’s website and other communications, and for coordinating and scheduling all meetings, bimonthly seminars, international workshops, and outreach events. The combined expertise of the Administrative Core’s leadership and staff will ensure that ICAL’s scientific and programmatic goals are met and disseminated in an impactful way to cannabinoid researchers as well as the entire scientific community and the public at large.