ICAL: Impact of Cannabinoids Across Lifespan: Administrative Core

ICAL：大麻素对整个生命周期的影响：管理核心

• 批准号: 10188474
• 负责人: Daniele Piomelli
• 金额: $ 31.68万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188474
• 关键词: Adolescence; Anatomy; Animals; Architecture; Behavior; Behavioral; Biochemistry; Biological Pharmacology; Budgets; Cannabinoids; Cannabis; Cognition; Communication; Communities; Educational workshop; Electrophysiology (science); Ensure; Epigenetic Process; Event; Exposure to; Genetic Processes; Goals; Institutes; International; Leadership; Logistics; Longevity; Mentors; Molecular; Molecular Structure; National Institute of Drug Abuse; Neurobiology; Neurosciences; Process; Protocols documentation; Reporting; Research; Research Personnel; Research Project Grants; Resources; Schedule; Specialist; Synapses; System; Testing; Tetrahydrocannabinol; Wood material; Work; addiction; endogenous cannabinoid system; experience; meetings; member; motivated behavior; operation; outreach; professor; programs; synaptic function; web site

PROJECT SUMMARY: ADMINISTRATIVE CORE We propose the creation of a NIDA Center of Excellence, Impact of Cannabinoids Across the Lifespan (ICAL), to test the hypothesis that non-physiological activation of the endocannabinoid system in adolescence – caused by exposure to D9-tetrahydrocannabinol (THC) or one of its synthetic mimics – initiates a reprogramming of the genetic and epigenetic processes that govern this system’s molecular structure, neuroanatomical architecture, and synaptic functions, ultimately producing persistent abnormalities in cognition and motivated behavior. To test this hypothesis, ICAL will deploy a vertically integrated strategy combining molecular, neuroanatomical, electrophysiological, and behavioral approaches. The Administrative Core will serve as the organizational hub for all ICAL’s scientific and programmatic activities. The overall goal of this core will be to centralize these activities while promoting efficiency in operations and transparency for ICAL investigators, trainees, and staff. The Administrative Core’s scientific leadership will oversee and integrate the activities of ICAL’s three research projects, two shared research cores, pilot core, and outreach activities. The core director, Daniele Piomelli is Professor in the Departments of Anatomy & Neurobiology, Biological Chemistry and Pharmacology, the Louise Turner Arnold Chair in the Neurosciences, and director of the newly created UCI Institute for the Study of Cannabis. The core co-director, Marcelo Wood, is Professor and Chair in the Department of Neurobiology & Behavior, and director of the Irvine Center for Addiction Neuroscience. Drs. Piomelli and Wood will leverage the expertise of distinguished members of UCI’s neuroscience community to form the Center’s internal Steering Committee (SC). In addition, they will assemble an External Advisory Group (EAG) composed of leaders in the field of neuroscience and cannabinoid research. The director and co-director will work with an experienced Program Specialist to develop systems and processes to manage workflow, coordinate meetings, facilitate interaction with ICAL’s SC and EAG and other stakeholders, track and report the Center’s progress, identify challenges and implement solutions. The Program Specialist will be responsible for budget management and reporting, drafting and maintaining of animal protocols, generating content for ICAL’s website and other communications, and for coordinating and scheduling all meetings, bimonthly seminars, international workshops, and outreach events. The combined expertise of the Administrative Core’s leadership and staff will ensure that ICAL’s scientific and programmatic goals are met and disseminated in an impactful way to cannabinoid researchers as well as the entire scientific community and the public at large.

项目概要：行政核心 我们建议建立一个NIDA卓越中心，大麻素对整个国家的影响， 寿命（ICAL），以检验内源性大麻素的非生理激活 青春期的系统-由暴露于D9-四氢大麻酚（THC）或其 合成模拟物-启动遗传和表观遗传过程的重新编程， 这个系统的分子结构、神经解剖结构和突触功能， 导致认知和动机行为的持续异常。为了检验这一假设， ICAL将部署一个垂直整合的战略，结合分子，神经解剖， 电生理学和行为学方法。行政核心将作为 ICAL的所有科学和计划活动的组织中心。这一核心的总体目标 将集中这些活动，同时提高业务效率和透明度， ICAL调查员、受训人员和工作人员。行政核心的科学领导将监督 并整合ICAL的三个研究项目，两个共享的研究核心，试点核心， 和外联活动。核心主任，丹尼尔Piomelli是教授在各部门的 解剖学和神经生物学，生物化学和药理学，路易丝特纳阿诺德椅子 他是新成立的UCI大麻研究所所长。 核心联合主任，马塞洛伍德，是教授和主席在神经生物学系和 他是欧文成瘾神经科学中心的主任。皮奥梅利医生和伍德医生 利用UCI神经科学界杰出成员的专业知识， 中心的内部指导委员会（SC）。此外，他们还将组建一个外部咨询机构， EAG由神经科学和大麻素研究领域的领导者组成。的 主任和副主任将与一位经验丰富的项目专家合作开发系统， 管理工作流程、协调会议、促进与ICAL SC和EAG互动的流程 和其他利益相关者，跟踪和报告中心的进展情况，确定挑战并实施 解决方案项目专员将负责预算管理和报告， 起草和维护动物协议，为ICAL网站和其他网站生成内容 通信，并协调和安排所有会议，双月研讨会， 国际讲习班和外联活动。行政部门的综合专门知识 核心的领导和工作人员将确保ICAL的科学和计划目标得到满足， 以一种有影响力的方式传播给大麻素研究人员以及整个科学界， 社区和广大公众。