Mechanism of action, homeostatic role and therapeutic effects of CD52

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T cells are required to fight infections but sometimes attack our tissues and cause autoimmune disease. T cells called regulatory T (Treg) cells suppress other T cells that cause autoimmune disease. We discovered a new type of Treg cell that suppresses other T cells by releasing from its surface a protein called CD52. We aim to discover how CD52 works and show that it can prevent autoimmune disease. We will gain insight into how the immune system regulates itself and may identify a new drug for the treatment of autoimmune diseases.