Mechanism of action, homeostatic role and therapeutic effects of CD52

CD52的作用机制、稳态作用和治疗作用

• 批准号: nhmrc : 1051484
• 负责人: Dr Tim Adams
• 金额: $ 27.4万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-action-homeostatic-effects-cd52/112219
• 关键词: Mechanism; action; homeostatic; role; therapeutic

T cells are required to fight infections but sometimes attack our tissues and cause autoimmune disease. T cells called regulatory T (Treg) cells suppress other T cells that cause autoimmune disease. We discovered a new type of Treg cell that suppresses other T cells by releasing from its surface a protein called CD52. We aim to discover how CD52 works and show that it can prevent autoimmune disease. We will gain insight into how the immune system regulates itself and may identify a new drug for the treatment of autoimmune diseases.

T细胞是抵抗感染所必需的，但有时也会攻击我们的组织，导致自身免疫性疾病。被称为调节性T(Treg)细胞的T细胞抑制其他导致自身免疫性疾病的T细胞。我们发现了一种新型的Treg细胞，它通过从表面释放一种名为CD52的蛋白质来抑制其他T细胞。我们的目标是发现CD52是如何发挥作用的，并证明它可以预防自身免疫性疾病。我们将深入了解免疫系统如何自我调节，并可能发现一种治疗自身免疫性疾病的新药。