Longitudinal trajectories of early childhood respiratory symptomatology and their impact on behavioral development

项目摘要 K23指导职业发展奖的申请整合了结构化的职业指导和 深入的研究培训与详细的研究计划旨在促进职业生涯作为一个独立的 乔纳森·S·利特的研究者，医学博士，公共卫生硕士，科学博士是贝斯以色列女执事医疗中心的一名妇科医生， 哈佛医学院儿科讲师。在奖励期结束时，Litt博士取得了 在先进的数据收集和分析技术及其应用方面具有高水平的方法专门知识 慢性呼吸道疾病和发育性共病的交叉轨迹， 旨在改善高危人群功能结果的干预措施。Litt博士的职业发展 一项计划涉及以下方面的培训：1）使用大型数据集来开发和测试假设，2）管理以患者为导向的 大队列研究，3）使用先进的纵向轨迹分析方法。的 这项K23奖项提案的首要科学目标是阐明发展之间的关系， 慢性呼吸道疾病（喘息，哮喘）和行为问题的高风险的临床样本 患有慢性肺病（CLD）的早产（PT）婴儿和一个基于大人群的出生队列。理解 这种关系将有助于告知有针对性的干预措施的内容和时间，以减少功能性 预防残疾，特别是在高危人群中。目的1是评估纵向 健康足月儿喘息相关呼吸状态与行为问题的关系 目的2是描述PT CLD婴儿中呼吸道症状的出现和轨迹。的 拟议研究的结果将填补理解身体健康和行为如何的关键空白。 功能随着时间的推移相互作用，并告知时间，建议干预措施的内容，以减少发病率 与儿童期慢性病相关的疾病，并提供R01补助金的基础。K23获奖 在此期间，利特博士将有能力申请进一步的联邦资金作为一个独立的调查员， 制定以证据为基础的干预措施。

Project Summary This application for a K23 mentored career development award integrates structured career mentorship and in- depth research training with a detailed research plan is designed to foster the career as an independent investigator of Jonathan S Litt, MD, MPH, ScD is a neonatologist at Beth Israel Deaconess Medical Center and Instructor of Pediatrics at Harvard Medical School. At the completion of the award period, Dr. Litt achieved a high level of methodological expertise in advanced data collection and analytic techniques and their application to the intersecting trajectories of chronic respiratory ailments and developmental comorbidities and developing interventions aimed at improving functional outcomes in high-risk populations. Dr. Litt's career development plan involves training in 1) using large data sets to develop and test hypotheses, 2) managing patient-oriented research with large cohorts, and 3) using advanced methods for longitudinal trajectory analysis. The overarching scientific aim of this K23 award proposal is to elucidate the relationship between the development of chronic respiratory disease (wheezing, asthma) and behavioral problems in a clinical sample of high-risk preterm (PT) infants with chronic lung disease (CLD) and a large population-based birth cohort. Understanding this relationship will help inform the content and timing of targeted interventions to decrease functional morbidities and prevent disabilities, particularly in high-risk populations. Aim 1 is to assess the longitudinal relationship between wheezing-related respiratory status and behavior problems in healthy term-born children. Aim 2 is to describe the emergence and trajectory of respiratory symptoms in among PT infants with CLD. The findings of the proposed studies will fill key gaps in understanding of how physical health and behavioral functioning interact over time and inform the timing, suggest content of interventions for reducing morbidities associated with chronic disease in childhood and provide the basis for an R01 grant. Following the K23 award period, Dr. Litt will be well-positioned to apply for further federal funding as an independent investigator to develop test evidence-based interventions.