Longitudinal trajectories of early childhood respiratory symptomatology and their impact on behavioral development

项目摘要 这份K23导师职业发展奖的申请书结合了结构化的职业指导和在- 深度研究培训和详细的研究计划旨在促进职业生涯的独立 乔纳森·S的研究员，医学博士，公共卫生硕士，SCD是贝丝以色列女执事医学中心的新生儿专家， 哈佛医学院儿科学讲师。在颁奖期结束时，利特博士取得了 在高级数据收集和分析技术及其应用方面具有高水平的方法学专长 慢性呼吸系统疾病与发育性合并症的交叉发展轨迹 旨在改善高危人群功能结局的干预措施。利特博士的职业发展 计划包括以下方面的培训：1)使用大数据集开发和测试假设；2)管理以患者为中心 进行大队列研究，以及3)使用先进的纵向轨迹分析方法。这个 这项K23奖项提案的主要科学目的是阐明发展与 慢性呼吸道疾病(喘息、哮喘)和行为问题的高危临床样本 患有慢性肺部疾病(CLD)的早产儿和大量以人口为基础的出生队列。理解 这种关系将有助于了解针对性干预的内容和时机，以减少 预防残疾，特别是在高危人群中。目标1是评估纵向 健康足月儿喘息相关呼吸状态与行为问题的关系 目的2描述甲状旁腺功能减退症(PT)合并慢性阻塞性肺疾病(CLD)患儿呼吸道症状的出现和发展轨迹。这个 拟议中的研究结果将填补在理解身体健康和行为 功能随着时间的推移相互作用，并告知时间，建议减少发病率的干预内容 与儿童时期的慢性病有关，并为R01赠款提供基础。继K23大奖之后 在此期间，利特博士将作为一名独立调查员申请进一步的联邦资金 制定基于证据的测试干预措施。

Project Summary This application for a K23 mentored career development award integrates structured career mentorship and in- depth research training with a detailed research plan is designed to foster the career as an independent investigator of Jonathan S Litt, MD, MPH, ScD is a neonatologist at Beth Israel Deaconess Medical Center and Instructor of Pediatrics at Harvard Medical School. At the completion of the award period, Dr. Litt achieved a high level of methodological expertise in advanced data collection and analytic techniques and their application to the intersecting trajectories of chronic respiratory ailments and developmental comorbidities and developing interventions aimed at improving functional outcomes in high-risk populations. Dr. Litt's career development plan involves training in 1) using large data sets to develop and test hypotheses, 2) managing patient-oriented research with large cohorts, and 3) using advanced methods for longitudinal trajectory analysis. The overarching scientific aim of this K23 award proposal is to elucidate the relationship between the development of chronic respiratory disease (wheezing, asthma) and behavioral problems in a clinical sample of high-risk preterm (PT) infants with chronic lung disease (CLD) and a large population-based birth cohort. Understanding this relationship will help inform the content and timing of targeted interventions to decrease functional morbidities and prevent disabilities, particularly in high-risk populations. Aim 1 is to assess the longitudinal relationship between wheezing-related respiratory status and behavior problems in healthy term-born children. Aim 2 is to describe the emergence and trajectory of respiratory symptoms in among PT infants with CLD. The findings of the proposed studies will fill key gaps in understanding of how physical health and behavioral functioning interact over time and inform the timing, suggest content of interventions for reducing morbidities associated with chronic disease in childhood and provide the basis for an R01 grant. Following the K23 award period, Dr. Litt will be well-positioned to apply for further federal funding as an independent investigator to develop test evidence-based interventions.