Early in vivo expressed antigens and their role in virulence, immune response, and vaccines for coccidioidomycosis

早期体内表达的抗原及其在球孢子菌病毒力、免疫反应和疫苗中的作用

• 批准号: 10356626
• 负责人: Paul Stephen Keim
• 金额: $ 26.49万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-24 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10356626
• 关键词: Accounting; Animal Model; Antigens; Area; Arizona; Award; Budgets; Businesses; Clinical; Clinical Research; Clinical Trials; Coccidioidomycosis; Collaborations; Communication; Communities; Data; Development; Diagnostic; Ensure; Evaluation; Faculty; Familiarity; Feedback; Fostering; Funding; Goals; Human Resources; Immune response; Individual; Institution; Joints; Knowledge; Lead; Leadership; Length; Life; Location; Medical center; Mentors; Monitor; National Institute of Allergy and Infectious Disease; Performance; Pilot Projects; Postdoctoral Fellow; Primates; Publications; Reporting; Research; Research Institute; Research Project Grants; Resources; Role; Schedule; Scheme; Series; Services; Structure; Students; Time; TimeLine; Training; Travel; United States National Institutes of Health; Universities; Vaccines; Videoconferencing; Virulence; Washington; Work; collaborative environment; desert fever; early-career faculty; experience; in vivo; innovation; meetings; member; novel vaccines; outreach; programs; research and development; student mentoring; success; synergism; translational genomics; virtual; working group

Administrative Core Section SUMMARY The Virulence, Immune Response, and Vaccine (VIRV) Cocci Cooperative Research Center (CCRC) will be directed by the administrative core (AdC) and a senior management team (SMT). The SMT is composed of Drs. Paul Keim (overall PI/PD), Bridget Barker, Deborah Fuller, and Erik Settles – all experienced scientific project managers. This is an aggregate effort by Northern Arizona University, University of Washington, the University of Arizona, the Kern Medical Center, the Tulane National Primate Research Center, and the Translational Genomics Research Institute that will capitalize upon the strengths of each institution and will synergistically foster a collaborative and productive scientific culture. Because it is a multi-Institutional program, coordination and communication are essential and will be an emphasis in the AdC. All of the individual Cores and Research Projects (RPs) will be represented on the SMT, which will provide effective vertical and horizontal communication, and management. Weekly meetings will be held within each of the CCRC components in addition to regular monthly cross-CCRC sessions to foster engagement and collaboration across the projects. All meetings will be supported by video conferencing and recorded, to lower participation barriers across the physical research locations. Slack accounts and channels will be an important part of the management communication scheme. Financial and compliance monitoring, along with reporting activities of the Cores and RPs, will be managed by the AdC, which includes a project manager with business accounting support. Major services, such as publication, animal models, and travel will be funded through the Cores to support the three individual RPs. Milestones and Timelines will be generated for each component and reviewed monthly during the SMT meetings. Outreach activities will be assessed and are part of the success metrics. Integral to these CCRC coordination efforts will be our program in Development Research Projects (DRPs) that will foster early career faculty, cross CCRC participation, and innovative ideas. The AdC will solicit, evaluate, award, and monitor the DRPs throughout the life of the VIRV-CCRC. Outreach will include our virtual seminar program and online forums to support the Valley Fever clinical and research communities, particular to other NIAID CCRC’s. Professional development, training, and mentoring of students, postdoctoral fellows, and junior faculty will be encouraged and supported by the AdC. Scientific working groups within and across the NIAID Cocci Centers will be fostered with the seminar series, travel funds, and joint pilot projects. The VIRV-CCRC team members will be expected to collaborate extensively and to produce relevant and impactful scientific products, including potentially a novel vaccine ready for clinical trials.

行政核心科 总结 毒力、免疫反应和疫苗（VIRV）球菌合作研究中心（CCRC）将在 由行政核心（AdC）和高级管理团队（SMT）领导。SMT由 Drs. Paul Keim（总体PI/PD）、Bridget Barker、Deborah Fuller和Erik Settles -均具有丰富的科学经验 项目经理。这是由北方亚利桑那大学、华盛顿大学、 亚利桑那大学、克恩医学中心、杜兰国家灵长类动物研究中心和 翻译基因组学研究所，将利用每个机构的优势，并将 协同促进协作和富有成效的科学文化。因为它是一个多机构 计划，协调和沟通是必不可少的，将是一个重点在AdC。所有 各个核心和研究项目（RP）将在SMT上代表，这将提供有效的 纵向和横向的沟通和管理。每周会议将在每个区域内举行， 除了每月定期的跨CCRC会议之外，CCRC组件还可以促进参与， 跨项目合作。所有会议都将得到视频会议的支持并进行录制， 降低物理研究地点的参与障碍。Slack账户和渠道将成为 管理沟通计划的重要组成部分。财务和合规监控，沿着 核心和RP的报告活动将由AdC管理，AdC包括一名项目经理 企业会计支持。主要的服务，如出版物，动物模型和旅行将是 通过核心方案提供资金，以支持三个独立的驻地代表。将生成里程碑和时间表 并在SMT会议期间每月进行审查。将评估外联活动 并且是成功指标的一部分。这些CCRC协调工作的组成部分将是我们的计划， 发展研究项目（DRPs），这将促进早期职业教师，跨CCRC参与， 创新的想法。AdC将在整个生命周期内征求、评估、奖励和监督DRP。 VIRV-CCRC。外联活动将包括我们的虚拟研讨会计划和在线论坛，以支持硅谷 发热临床和研究社区，特别是其他NIAID CCRC。专业发展， 将鼓励对学生、博士后研究员和初级教师进行培训和指导， 由Adc支持。将促进NIAID球菌中心内部和跨中心的科学工作组 研讨会系列、差旅费和联合试点项目。VIRV-CCRC团队成员将 预计将广泛合作，并产生相关和有影响力的科学产品，包括 可能是一种准备进行临床试验的新型疫苗。