Bone Histology and Imaging

项目总结/摘要 拟议中的阿肯色州大学肌肉骨骼疾病研究中心（CMDR）， 医学科学（UAMS）包括建立骨组织学和成像核心（核心C）。的 拟议的CMDR的科学主题是确定疾病和病症的分子原因 对肌肉骨骼系统产生负面影响或与该系统相互作用作为其疾病过程的一部分。 骨组织学和成像核心与此主题一致，因为它将交付给项目负责人 最先进的定量组织和细胞数据，用于表征结构、组织和细胞 研究中的肌肉骨骼疾病病理机制的基础变化。骨 因此，组织学和成像核心将是项目负责人成功的关键组成部分。的 核心将巩固现有的设备在UAMS校园到一个大型的，现代化的研究空间内， 矫形外科系，并将聘请有经验的人员在校园内，这将是监督 核心领导者。具体目标是：1）建立骨组织学和成像核心; 2）提供 最先进的肌肉骨骼成像、生物力学测试和组织学服务，并介绍新的 为CMDR项目负责人和教师提供分析技术; 3）提供骨组织形态计量学培训， 支持教育活动。骨组织学和成像核心的成功，与其他 CMDR核心，将支持发展一批关键的调查人员，以确保长期的 中心的可持续性和生产力。

PROJECT SUMMARY/ABSTRACT The proposed Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS) includes the establishment of the Bone Histology and Imaging Core (Core C). The scientific theme of the proposed CMDR is the identification of the molecular causes of diseases and conditions that negatively impact the musculoskeletal system or interact with this system as part of their disease process. The Bone Histology and Imaging Core is consistent with this theme in that it will deliver to the Project Leaders state-of-the-art quantitative tissue and cellular data for the characterization of the structural, tissue, and cellular changes that underlie the pathological mechanisms of the musculoskeletal diseases being studied. The Bone Histology and Imaging Core will therefore be a critical component for the success of the Project Leaders. The Core will consolidate existing equipment on the UAMS campus into a large, modern research space within the Department of Orthopaedic Surgery and will hire experienced personnel on the campus, which will be supervised by a Core Leader. The specific aims are: 1) To establish the Bone Histology and Imaging Core; 2) To deliver state-of-the-art musculoskeletal imaging, biomechanical testing, and histology services and introduce new analytical technologies to CMDR Project Leaders and faculty; 3) To provide bone histomorphometry training and support educational activities. The success of the Bone Histology and Imaging Core, in conjunction with the other CMDR cores, will support the development of a critical mass of investigators that will ensure the long-term sustainability and productivity of the Center.