Eye Movement Rehabilitation in Low Vision Patients

项目摘要/摘要 目前全球约有2.17亿人患有低视力，这影响了广泛的 这是日常生活活动的一部分，与抑郁症和死亡率增加有关。超过一半的患者 为低视力服务提供报告的人患有影响中心凹和周围黄斑的眼病，并导致 中心视力丧失(CVL)。患有CVL的人被迫使用偏心视力来替代他们受损的视力 中心凹，但眼球运动控制和视觉功能会因视力偏斜而受损。这项建议 汇集东北大学、灯塔协会和纽约大学的基础和临床视力科学家 英格兰验光学院，以帮助CVL患者学习更多地使用他们剩余的视力 有效地。 最近的证据表明，康复方法可以帮助改善眼球运动控制，这可能导致 改善了功能结果。我们已经开发了基于反馈的新方法，旨在改进 CVL患者的偏心视力训练。在一系列研究中，我们考察了固定的康复。 控制，跟踪移动对象的流畅追逐眼球运动和扫视眼球运动 突然改变了关注点。我们研究了视觉反馈、盲点感知方法和 手眼协调可以改善偏心视觉的使用。眼球运动控制方面的改进是 用眼睛跟踪方法进行量化以及视觉功能的相关变化用敏锐度来量化， 对比敏感度和读数性能。 因此，拟议的研究发展并将最先进的基础科学方法转化为临床方法。 申请。实现拟议的目标将为康复提供新的和改进的方法 视力障碍的治疗策略。这项建议的最终目标是最大化残存的视觉功能 帮助视力低下的人独立生活，从而提高生活质量，最大限度地减少 视力损害造成的经济和社会负担。

Project Summary/ Abstract Approximately 217 million people worldwide currently suffer from low vision, which impact a broad range of activities of daily living and is associated with depression and increased mortality. Over half of the patients presenting for low vision services have eye disease that affects the fovea and surrounding macula and leads to central vision loss (CVL). People with CVL are forced to use eccentric vision as a substitute for their impaired fovea, however eye movement control and visual function is impaired with eccentric vision. This proposal brings together basic and clinical vision scientists at Northeastern University, the Lighthouse Guild and New England College of Optometry in order to help people with CVL to learn to use their remaining vision more effectively. Recent evidence shows that rehabilitation methods can help improve oculomotor control and this can lead to improved functional outcomes. We have developed new feedback-based methods that aim to improve eccentric vision training in patients with CVL. In a series of studies we examine rehabilitation of fixation control, smooth pursuit eye movements that track moving objects and saccadic eye movements that abruptly change the point of regard. We examine how visual feedback, scotoma awareness methods and hand-eye coordination can improve eccentric vision usage. Improvements in oculomotor control are quantified with eye tracking methods and associated changes in visual function are quantified with acuity, contrast sensitivity and reading performance. The proposed research therefore develops and translates state-of-the-art methods in basic science to clinical applications. Accomplishing the proposed aims will provide new and improved methods for rehabilitation strategies for visual impairment. The ultimate goal of this proposal is to maximize the residual visual function of people with low vision and to help them to live independently, thereby improving quality of life and minimizing the economic and social burden of visual impairment.