Core B: MPN-RC Tissue Bank

摘要 核心B，组织库提供运输、接收、处理、储存和 分发从骨髓增生性肿瘤（MPN）患者获得的组织标本， 以及参加临床试验的患者（项目4）。这些样本已提供给MPN-RC 研究人员进行翻译研究的目的是开发创新 治疗（项目1 -3）和生物标志物和生物信息学核心D进行生物标志物 分析，以评估特定疗法对消耗MPN造血干细胞的有效性 和祖细胞（HSC/HPC）。组织也可提供给科学委员会的成员， 在整个社区进行翻译研究。翻译研究依赖于准备好的 从足够数量的准确诊断的患者中获得组织， 有统计意义的数据。由于MPN相对不常见，并且其准确性 诊断可能是困难的，一直缺乏组织，与临床数据，可用于 单个研究机构的个体研究者。核心B填补了这一空白。我们的库存 核心B保持了来自1500多名MPN患者的15000多份标本， 世界上最大的可用于研究的MPN组织库存之一。此外，核心B 从参与MPN-RC申办的临床试验（项目4）的患者中采集标本， 进行生物标志物研究的目的是证明特异性 MPN造血干细胞和祖细胞（HSC/HPC）耗竭的治疗。的 组织库核心B的具体目标是：1）接收、处理、冷冻保存和储存 来自MPN患者以及在MPN-RC参加临床试验（项目4）的患者的组织 2）为与基础数据相关的MPN组织提供中央储存库 存储在由生物统计和数据管理核心C维护的基于网络的数据库中 包括临床和实验室数据，这些数据使得能够选择和分布最适合的组织 每个转化研究项目; 3）将组织分发给：MPN联盟研究者 用于转化研究以开发创新疗法; MPN联盟研究人员 分析生物标志物，以确定对治疗的治疗和药效学反应， 以及预测疾病进展;和科学界广泛的翻译 research.组织可供MPN研究联盟（MPN-RC）成员使用， 为广大科学界开展转化研究提供了机会。核心B是一个 重要的共享资源，使转化研究，最终将导致 分子靶向治疗的发展。

Abstract Core B, Tissue Bank provides the infrastructure to transport, receive, process, store, and distribute tissue specimens obtained from patients with myeloproliferative neoplasms (MPN) as well as patients enrolled on clinical trials (Project 4). These specimens are provided to MPN-RC investigators performing translational research for the purpose of developing innovative therapies (Projects1-3) and to the Biomarker & Bioinformatics Core D to perform biomarker analyses to evaluate the effectiveness of specific therapies to deplete MPN hematopoietic stem and progenitor cells (HSC/HPC). Tissues are also available to members of the scientific community at large for translational research. Translational research is dependent on the ready availability of tissues from a sufficient number of accurately diagnosed patients to generate statistically significant data. Because the MPNs are relatively uncommon and their accurate diagnosis can be difficult, there has been a paucity of tissue, linked to clinical data, available to individual investigators at single institutions. Core B fills this void. With an inventory of more than 15000 specimens from more than 1500 individual patients with MPNs, Core B maintains one of the world's largest inventories of MPN tissues available for research. In addition, Core B collects specimens from patients participating in MPN-RC sponsored clinical trials (Project 4) for the purpose of performing biomarker studies to demonstrate the effectiveness of specific therapies on the depletion of MPN hematopoietic stem and progenitor cells (HSC/HPC). The specific aims of Tissue Bank Core B are to: 1) Receive, process, cryopreserve, and store tissues from MPN patients as well as patients enrolled on clinical trials (Project 4) at MPN-RC clinical sites; 2) Provide a central repository for MPN tissues that are associated with basic data stored in the web-based data bank maintained by Biostatistics and Data Management Core C including clinical, and laboratory data that enable selection and distribution of tissues best suited for each translational research project; 3) Distribute tissues to: MPN Consortium investigators for translational research to develop innovative therapies; MPN Consortium investigators to analyze biomarkers to determine therapeutic and pharmacodynamic response to therapy as well as to predict disease progression; and scientific community at large for translational research. Tissues are available to members of the MPN Research Consortium (MPN-RC) and to the scientific community at large for the performance of translational research. Core B is an essential shared resource that enables translational research that will ultimately lead to the development of molecularly targeted therapies.