Addiction Connectome Core

项目摘要：成瘾连接体核心 大脑区域之间的连接模式(大脑的接线图)决定了它们之间的沟通方式 最终，他们如何对行为做出贡献。了解药物对连接性的影响是至关重要的 用来确定成瘾的机制。最近在神经成像方面的创新使科学家能够 研究整个大脑的神经连接。这项研究主要发生在人类身上。同时， 动物模型中的侵入性方法导致了大量关于细胞变化的信息。然而，这两个人 这些方法在很大程度上仍然是脱节的。成瘾连接核心(ACC)将在这一翻译过程中架起桥梁 通过支持小鼠和猴子的全脑、多模式连接体的发展，GAP。这个 Connectome将揭示成瘾的预测因素和后果。除了开发 基础设施和为Connectome收集核心数据，我们将开发一个基于Web的可搜索数据库 这也有助于在小鼠和猴子体内集成来自多个方法学来源的数据 在接触了两种药物后。行政协调会将整合和公开与其有关的数据 特派团有三个来源：(1)专门为核心收集的数据，(2)其他核心收集的数据 (结构电路核心和行为核心期间的成像细胞)，以及(3)由外部收集的数据 科学家。因此，核心将导致生成和管理可搜索、可发现和有组织的 与上瘾有关的大脑解剖学综合数据库。

PROJECT SUMMARY: Addiction Connectome Core The pattern of connections between brain regions (the brain’s wiring diagram) determines how they communicate and ultimately, how they contribute to behavior. Understanding how connectivity changes with drugs is essential for determining the mechanisms of addiction. Recent innovations in neuroimaging have allowed scientists to study neural connectivity across the whole brain. This work has taken place mostly in humans. At the same time, invasive methods in animal models have led to a wealth of information on cellular changes. However, these two approaches remain largely disconnected. The Addiction Connectome Core (ACC) will bridge this translational gap by supporting the development of a whole-brain, multimodal connectome in mice and monkeys. The connectome will shed light of the predictors and consequences of addiction. In addition to developing the infrastructure and collecting core data for the connectome, we will develop a web-based searchable database that also facilitates integration of data in mice and monkeys from multiple methodological sources before and after exposure to two types of drugs. The ACC will integrate and make publicly available data bearing on its mission from three sources: (1) data specifically collected for the Core, (2) data collected by the other Cores (Structural Circuits Core and Imaging Cells during Behavior Core), and (3) data collected by extramural scientists. As such, the core will lead to the generation and curation of a searchable, discoverable, and organized integrated database of brain anatomy as it relates to addiction.