Substance use prevention for youth with parents in recovery: a pilot randomized controlled trial

父母康复中的青少年的药物使用预防：一项随机对照试验

• 批准号: 10372551
• 负责人: Caroline Kistin
• 金额: $ 27.01万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10372551
• 关键词: Adolescence; Adolescent; Adolescent and Young Adult; Adult; Advisory Committees; Age; Age-Years; Alcohols; Behavioral; Child; Clinical Trials; Clinical Trials Design; Cognitive; Communication; Consent; Control Groups; Coping Skills; Data; Development; Drops; Drug usage; Elderly; Family; Family Planning; Family member; Feasibility Studies; Feedback; Future; Goals; Home; Household; Human Resources; Infrastructure; Intervention; Intervention Trial; Interview; Knowledge; Life; Life Cycle Stages; Logistics; Marijuana; Measures; Medical center; Mental Depression; Modeling; Opioid; Outcome; Parent-Child Relations; Parents; Patient Recruitments; Peptide Initiation Factors; Pilot Projects; Population; Population Heterogeneity; Preparation; Prevention strategy; Preventive service; Primary Health Care; Problem Solving; Process; Public Health; Randomized; Randomized Controlled Trials; Recovery; Reporting; Research; Risk; Risk Factors; Series; Service delivery model; Services; Structure; Substance Use Disorder; Techniques; Testing; Time; Work; Youth; acceptability and feasibility; adolescent substance use; arm; base; disorder prevention; efficacy study; efficacy testing; efficacy trial; evidence base; experience; field study; follow-up; high risk; high risk population; human centered design; improved; improved outcome; intervention delivery; intervention refinement; meetings; misuse of prescription only drugs; novel; opioid epidemic; opioid use; opioid use disorder; parent-child communication; parental involvement; patient oriented; pilot test; prevent; preventive intervention; primary care setting; protective factors; prototype; provider intervention; public health priorities; randomized trial; resilience; skills; substance use; substance use prevention; substance use treatment; synthetic cannabinoid; willingness; young adult

PROJECT SUMMARY Risk for substance use disorder (SUD) begins early in the life course. Although preventing and decreasing illicit and nonmedical drug use among youth is an urgent public health priority, there are currently few evidence- based prevention strategies feasible for delivery in the primary care setting. We propose a three-year plan to collect critical pilot data to pilot test and optimize a dyadic intervention that aims to increase family resilience, strengthen coping skills, help families plan for the future, and prevent youth SUD. Currently, over 12% of children in the US live in households with at least one parent who has SUD, including an estimated 3 million children between the ages of 12 and 17. Parental SUD is a known risk factor for the initiation and progression of substance use in adolescence and young adulthood. At the same time, parental recovery from SUD has been shown to be protective against youth substance use, particularly when there are supports in place to promote supportive parent-child relationships, problem solving skills, and effective family coping strategies. A key premise of our work is that an effective SUD prevention strategy for high-risk youth therefore needs to incorporate the family unit deliberately in the intervention process. The long-term objective of this proposed trajectory of work is to prevent substance use among a selective population of youth whose parents are in recovery from SUD. The ‘prototype’ for our intervention approach is Family Talk, an evidence-based parent-youth dyadic intervention that can be delivered within the existing infrastructure of the patient-centered medical home. We have made preliminary adaptations to the model in preparation for testing. To prepare for a subsequent efficacy study, we will conduct a two-arm pilot randomized controlled trial of the intervention with 40 parent- youth dyads to optimize the intervention model; evaluate feasibility; obtain empiric estimates of study parameters to inform the planning of a fully powered randomized controlled trial; and identify plausible intervention targets using semi-structured qualitative interviews. The product at the end of this R34 will be an optimized intervention model, ready for efficacy testing, adapted with parent and youth input. Our ultimate goal is to develop an effective approach to youth substance use prevention that can be delivered within the infrastructure of the patient-centered medical home. If successful, this trajectory of work has the potential to identify a novel, family-centered approach to SUD prevention for a high-risk population of youth whose parents are in recovery from SUD.

项目摘要 物质使用障碍（SUD）的风险开始于生命过程的早期。虽然预防和减少非法 青少年的非医疗药物使用是一个紧迫的公共卫生优先事项，目前几乎没有证据表明- 在初级保健环境中实施可行的预防战略。我们提出一个三年计划， 收集关键的试点数据，对旨在提高家庭复原力的二元干预措施进行试点测试和优化， 加强应对技能，帮助家庭规划未来，并预防青少年吸毒。 目前，超过12%的美国儿童生活在父母至少一方患有SUD的家庭中，包括 估计有300万12至17岁的儿童。父母SUD是一个已知的风险因素， 青少年和青年期物质使用的开始和发展。与此同时，父母 从SUD恢复已被证明是对青少年物质使用的保护，特别是当有 提供支持，以促进支持性的亲子关系、解决问题的技能和有效的家庭 应对策略我们工作的一个重要前提是，为高危青少年制定有效的SUD预防战略， 因此，需要有意识地将家庭单位纳入干预过程。长期目标 这一拟议的工作轨迹的一个重要方面是防止有选择的青年人口使用药物， 父母正在从SUD中恢复。 我们的干预方法的“原型”是家庭谈话，一个以证据为基础的父母-青年二元 在以患者为中心的医疗之家的现有基础设施内可以提供的干预。我们 已经对模型进行了初步调整，为测试做准备。为接下来的 疗效研究，我们将进行一项两组试点随机对照试验的干预与40名家长， 青年二人组干预模式优化;可行性评价;获得研究的经验估计值 参数，以通知规划一项完全把握度的随机对照试验;并确定合理的 采用半结构化定性访谈的干预目标。 R34结束时的产品将是一个优化的干预模型，可用于有效性测试， 家长和青少年的参与我们的最终目标是制定一个有效的方法，以青少年物质使用 可以在以病人为中心的医疗之家的基础设施内提供的预防。如果成功， 这种工作轨迹有可能确定一种新的，以家庭为中心的方法来预防SUD， 父母正在从SUD中恢复的青年高危人群。