Convergence of Vitamin E, THC, Nicotine, Propylene Glycol and Glycerin Effects on Lung Inflammation When Vaped

维生素 E、THC、尼古丁、丙二醇和甘油的综合作用对电子烟时肺部炎症的影响

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT Since becoming an Associate Professor two and a half years ago, I think back to my years as an Assistant Professor and realize that my greatest moments of joy came from my mentee’s successes. Moments where they were awarded their first grant, obtained their first faculty position and a high-impact first authored paper was accepted all shine brightly in my memories. Equally important were the moments where a trainee came to see me because they were feeling unsuccessful or unmotivated, and they felt they were not going to succeed in academics, and through our conversation they arose, reassured about their good ideas, skill set and ability to move forward in a positive and productive way. Looking forward, I worry about the amount of time committed to administrative and clinical efforts and believe that obtaining protected time via this K24 will directly lead to development and enrichment in three areas: 1. Mentoring, 2. Conducting cutting-edge novel research, and 3. Learning new patient oriented research skills. I truly believe that expanding my time dedicated to mentorship will have the greatest impact out of the three, because enhancing and supporting the training of passionate, clever, dedicated trainees will lead to broader effects across medicine and academics relative to my research alone. In terms of research, e-cigarettes are drug delivery (vaping) devices that entered the country in 2007 and have exploded in terms of use, especially in adolescents and young adults whom have never smoked. We have no longitudinal data on the health effects of vaping, particularly on lung and systemic inflammation. By leveraging our existing cohort of young e-cigarette vapers at UCSD, the research proposed here can obtain longitudinal data by having these subjects return at 1 and 2 years, thus giving 3 timepoints across which changes in airway inflammation, microbiome and reactivity, and systemic inflammation can be defined. These data will help us understand which chronic diseases will arise from chronic e-cigarette use. Asthmatics are using e-cigarettes at a high rate, most likely because of the successful advertising campaigns tobacco companies have run, convincing many of the lack of adverse effects of these devices. But patients with asthma have airways and systemic inflammation, thus they are likely to be more susceptible to the pro-inflammatory and immunomodulatory effects of vaping. By again leveraging the ongoing patient-oriented research conducted by our team, I propose here to recruit vaping and non-vaping subjects with TH2-high allergic asthma to assess the effects of e-cigarette aerosol inhalation on their underlying disease state. Finally, I propose to dive deeper into clinical research design and analysis, to improve my ability to conduct high level patient oriented research and thus yield the highest quality, relevant data possible. With the support of my own mentors (Drs. Atul Malhotra and Victor Nizet), the support of UCSD, my existing fantastic research team and the mentees to come, I believe the support of this K24 will make it possible to thrive as a mentor, researcher and life-long learner.
项目总结/文摘

项目成果

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Laura Elise Crotty Alexander其他文献

Laura Elise Crotty Alexander的其他文献

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{{ truncateString('Laura Elise Crotty Alexander', 18)}}的其他基金

Developing a Diverse Next Generation of Leaders in Respiratory Science
培养多元化的下一代呼吸科学领导者
  • 批准号:
    10555145
  • 财政年份:
    2023
  • 资助金额:
    $ 12.17万
  • 项目类别:
Convergence of Vitamin E, THC, Nicotine, Propylene Glycol and Glycerin Effects on Lung Inflammation When Vaped
维生素 E、THC、尼古丁、丙二醇和甘油的综合作用对电子烟时肺部炎症的影响
  • 批准号:
    10546469
  • 财政年份:
    2022
  • 资助金额:
    $ 12.17万
  • 项目类别:
Electronic Cigarette Vapor Inhalation Adversely Affects Lung Cellular and Physiologic Function and Alters Systemic Inflammatory Pathways
电子烟蒸气吸入会对肺细胞和生理功能产生不利影响,并改变全身炎症途径
  • 批准号:
    10220439
  • 财政年份:
    2020
  • 资助金额:
    $ 12.17万
  • 项目类别:
Hypoxia inducible factors in pulmonary endothelial cells regulate allergic inflammatory airways disease
肺内皮细胞缺氧诱导因子调节过敏性炎症性气道疾病
  • 批准号:
    10292906
  • 财政年份:
    2019
  • 资助金额:
    $ 12.17万
  • 项目类别:
Hypoxia inducible factors in pulmonary endothelial cells regulate allergic inflammatory airways disease
肺内皮细胞缺氧诱导因子调节过敏性炎症性气道疾病
  • 批准号:
    10515302
  • 财政年份:
    2019
  • 资助金额:
    $ 12.17万
  • 项目类别:
Hypoxia inducible factors in pulmonary endothelial cells regulate allergic inflammatory airways disease
肺内皮细胞缺氧诱导因子调节过敏性炎症性气道疾病
  • 批准号:
    10045518
  • 财政年份:
    2019
  • 资助金额:
    $ 12.17万
  • 项目类别:
Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
HIF-1a 在哮喘中作用的遗传学和药理学评价
  • 批准号:
    8305975
  • 财政年份:
    2011
  • 资助金额:
    $ 12.17万
  • 项目类别:
Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
HIF-1a 在哮喘中作用的遗传学和药理学评价
  • 批准号:
    8698286
  • 财政年份:
    2011
  • 资助金额:
    $ 12.17万
  • 项目类别:
Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
HIF-1a 在哮喘中作用的遗传学和药理学评价
  • 批准号:
    8143209
  • 财政年份:
    2011
  • 资助金额:
    $ 12.17万
  • 项目类别:
Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
HIF-1a 在哮喘中作用的遗传学和药理学评价
  • 批准号:
    8402123
  • 财政年份:
    2011
  • 资助金额:
    $ 12.17万
  • 项目类别:

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Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
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青少年和青年癌症成年幸存者心血管危险因素和心血管疾病的发病率和时间以及与运动的关系
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