Molecular mechanism of the PRC-dependent RNA degradation by the rixosome

核糖体PRC依赖性RNA降解的分子机制

• 批准号: DP240101212
• 负责人: Dr Qi Zhang
• 金额: $ 37.65万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101212
• 关键词: Molecular; mechanism; PRC; dependent; RNA

Polycomb repressive complexes (PRCs) and the rixosome are evolutionarily conserved enzymes that are required for silencing the developmental genes of multicellular organisms. This project aims to investigate how these key regulators maintain gene repression using cutting-edge approaches ranging from biochemistry, structural biology, cell biology to genomics. The expected outcomes include generating new knowledge in gene regulation, strengthening the research capabilities of Australia in fundamental biology, and training the next generation of scientists.

多梳抑制复合物（PRCs）和rixosome是进化上保守的酶，需要沉默多细胞生物的发育基因。该项目旨在研究这些关键调控因子如何使用生物化学，结构生物学，细胞生物学和基因组学等尖端方法维持基因抑制。预期成果包括产生基因调控方面的新知识，加强澳大利亚在基础生物学方面的研究能力，以及培训下一代科学家。