Emory Alzheimer's Disease Research Center

摘要/摘要：生物标志物核心 阿尔茨海默病(AD)是一种慢性疾病，会在漫长的无症状期内进展 在进入轻度认知障碍(MCI)和痴呆期之前。使用当前的生物标记物 工具，我们可以相当有把握地确定是否存在AD相关的病理 在一个活着的个体身上。然而，AD生物标记物的能力仍然存在重大限制，并且 迫切需要新的生物标记物来克服剩余的障碍。建议的生物标记物 CORE将通过追求三个具体目标来支持埃默里ADRC的研究活动：1)执行 分析标准化遗传图谱，发掘有潜力的候选者；2)执行和分析 标准化的脑脊液AD生物标记物分析和发掘有前途的候选者；3)执行和分析 标准的脑成像和评估有前景的附加序列。建议的生物标志物核心 将为研究环境提供一些重要的改进。纵向采集 公共数据集，包括临床信息、脑脊液AD生物标志物、核心遗传信息和 标准的脑MRI序列将提供测试新的AD生物标记物的基础， 评估并确认。每一个领域的探索性研究都应该提供有意义的 脑脊液蛋白质组学、新的磁共振序列和基因组数据的进展。最后，目前的提案 聘请一群才华横溢的调查人员，他们将把他们的专业知识带给ADRC和更大的 研究社区。这些要素中的每一个都推进了非盟的总体目标，并将提供一种 为新学员提供丰富的数据。

SUMMARY/ABSTRACT: BIOMARKER CORE Alzheimer’s disease (AD) is a chronic disease that progresses through a lengthy asymptomatic period before entering a period of mild cognitive impairment (MCI) and dementia. Using current biomarker tools, we can determine with a fair degree of confidence whether or not AD-related pathology is present in a living individual. However, there remain major limitations in the capabilities of AD biomarkers, and there is a critical need for new biomarkers to overcome remaining barriers. The proposed Biomarker Core will support research activities in the Emory ADRC by pursuing three Specific Aims: 1) Perform and analyze standardized genetic profiling and explore promising candidates; 2) Perform and analyze standardized CSF AD biomarker assays and explore promising candidates; 3) Perform and analyze standard brain imaging and evaluate promising additional sequences. The proposed Biomarker Core will provide a number of important enhancements to the research environment. Longitudinal collection of common datasets, including clinical information, CSF AD biomarkers, core genetic information, and standard brain MRI sequences, will provide foundations upon which new AD biomarkers can be tested, evaluated, and confirmed. Exploratory research in each of these areas should provide significant advances in CSF proteomics, new MR sequences, and genomic data. Lastly, the current proposal engages a group of talented investigators who will bring their expertise to the ADRC and the larger research community. Each of these elements advance the overall goals of the ADRC and will provide a wealth of data for new trainees.