Development of a Region-Specific JEM for Exposure Surveillance

项目摘要 职业暴露监测对于识别处于危险中的工人群体是必要的。 发展职业病和缓解工作的优先次序，但目前美国在很大程度上没有 国家职业健康监测系统。目前迫切需要发展 监测方法和系统，以促进美国职业暴露趋势的检查。的 拟议研究的总体目标是构建一般人群工作暴露矩阵（JEM）， 密歇根州和联邦第5区各行业的化学危害，并评估暴露和 单一和混合灾害的过度蔓延趋势和普遍性。目标1将涉及建造这些 JEM和多个风险指数的建模以及风险随时间的变化趋势， 行业目标2将根据共同的不利健康影响对这些接触进行分组，并将量化 混合暴露的可能性。目标3将估计风险暴露和过度暴露的普遍程度， 密歇根州和第5区的危害和健康影响分组。这些目标的结果将用于确定目标 外展、教育和干预措施作为总体职业健康监测计划的一部分， 密歇根州通过密歇根州立大学（MSU）运营，并将与密歇根州职业教育局共享 安全和健康管理局（MIOSHA），以帮助优先考虑行业的合规活动。 这项研究将跨越诺拉部门，并与癌症，生殖，心血管 和其他疾病预防，免疫，传染病和皮肤病预防，以及呼吸系统健康 诺拉跨部门。它将直接解决NIOSH与暴露有关的战略和中期目标 监测，并为今后的流行病学研究提供接触评估工具， NIOSH关于暴露与不良健康之间关系的表征的目标 结果。该项目符合NIOSH研究实践（r2 P）方法，因为其结果将是 直接与MIOSHA和雇主/雇员团体分享，MSU计划与他们有关系， 以确定和接触风险工人群体，以减轻接触风险。 通过这个项目，Oliveri博士将完成一个职业发展计划， 密歇根州立大学的Kenneth Rosenman博士和密歇根大学的Richard Neitzel博士 密歇根公共卫生学院（UMSPH），体验式学习和正式课程。该计划将增加 博士Oliveri在接触分析和JEM施工、职业安全和环境保护方面的经验和能力 健康监测、职业流行病学和先进的统计技术。MSU Division of 职业和环境医学和环境卫生科学部， 流行病学将为Oliveri博士提供必要的资源和智力支持，以完成 拟议的职业发展和研究活动。

Project Summary Occupational exposure surveillance is necessary for the identification of worker populations at risk of developing occupational disease and the prioritization of mitigation efforts but is largely absent from current US national occupational health surveillance systems. There is an urgent and unmet need for the development of surveillance methods and systems to facilitate the examination of occupational exposure trends in the US. The overall objective of the proposed study is to construct general-population job-exposure matrices (JEMs) for chemical hazards across industries in Michigan and Federal Region 5 and to assess exposure and overexposure trends and prevalence for single and mixed hazards. Aim 1 will involve the construction of these JEMs and the modeling of multiple indices of exposure as well as the trends in exposures over time across industries. Aim 2 will group these exposures according to shared adverse health effects and will quantify the potential for mixed exposures. Aim 3 will estimate the prevalence of exposures and overexposures across hazards and health effect groupings in Michigan and Region 5. The results of these aims will be used to target outreach, education, and interventions as part of an overarching occupational health surveillance program for Michigan operated through Michigan State University (MSU) and will be shared with the Michigan Occupational Safety and Health Administration (MIOSHA) to aid in the prioritization of industries for compliance activities. This research will span NORA sectors and be relevant to the Cancer, Reproductive, Cardiovascular and Other Disease Prevention, Immune, Infectious, and Dermal Disease Prevention, and Respiratory Health NORA cross-sectors. It will directly address NIOSH strategic and intermediate goals pertaining to exposure surveillance as well as providing an exposure assessment tool for future epidemiological studies supporting NIOSH goals relating to the characterization of relationships between exposures and adverse health outcomes. The project aligns with the NIOSH Research to Practice (r2P) approach, as the outcomes will be shared directly with MIOSHA and employer/employee groups with whom the MSU program has relationships in order to identify and reach at-risk worker groups for exposure mitigation. Through this project, Dr. Oliveri will complete a plan for career development that will involve a combination of mentorship from Drs. Kenneth Rosenman at MSU and Richard Neitzel at the University of Michigan School of Public Health (UMSPH), experiential learning, and formal coursework. This plan will add to Dr. Oliveri’s experience and capabilities regarding exposure analysis and JEM construction, occupational health surveillance, occupational epidemiology, and advanced statistical techniques. The MSU Division of Occupational and Environmental Medicine and UMSPH Departments of Environmental Health Sciences and Epidemiology will provide Dr. Oliveri with the resources and intellectual support necessary to complete the proposed career development and research activities.