Integrated Toxicomics & Environmental Measurement Facility Core

综合毒理学

• 批准号: 10217139
• 负责人: Michael L Merchant
• 金额: $ 13.55万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10217139
• 关键词: Applications Grants; Attention; Award; Awareness; Biometry; Budgets; Cells; Chronic Disease; Communities; Core Facility; DNA; Data; Data Analyses; Disease; Environmental Health; Equipment; Event; Experimental Designs; Exposure to; Funding; Genomics; Goals; Grant; Health; Health Sciences; Human; Informatics; Inhalation; Inhalation Exposure; Institution; Interest Group; Investments; Laboratories; Malignant Neoplasms; Measurement; Measures; Metabolic; Metagenomics; Metals; Modernization; National Institute of Environmental Health Sciences; Pathologic; Pilot Projects; Pollution; Proteins; Proteomics; RNA; Research; Research Design; Research Personnel; Resource Sharing; Resources; Running; Sampling; Scientist; Services; Suggestion; Techniques; Technology; Tissues; Toxic Environmental Substances; Toxicogenetics; Toxicology; Universities; Work; base; citizen science; community engagement; cost; data acquisition; environmental toxicology; faculty community; health science research; interest; lifestyle factors; medical schools; member; metabolomics; neurodevelopment; next generation; programs; shared attention; toxicant interaction; transcriptomics

The Center for Integrated Environmental Health Sciences (CIEHS) goals are to understand how life style factors interact with exposure to environmental toxicants in human health and disease, and to enhance the capacity for environmental health research at the University of Louisville (UofL). UofL shared resource facility cores offer cutting edge scientific services, enabling access to high-end equipment, advanced techniques and specialized expertise that would typically be inaccessible for an investigator. It is essential for the modern environmental health scientist to understand the numerous available shared resource facility cores; in terms of accessibility, effective experimental design, data- acquisition and -analyses. The Integrated Toxicomics and Environmental Measurement Facility Core (ITEMFC) will create a central resource for CIEHS members, allowing them to understand, access and effectively use environmental ‘omics resources. The ITEMFC will coordinate activities between CIEHS members and the existing UofL shared resource facility cores. The ITEMFC will be comprised of six discrete technology-centric components: genomics/ transcriptomics, proteomics, metabolomics, metallomics, metagenomics, and controlled inhalation exposure studies. The ITEMFC will focus its efforts on advising investigators on study design, facilitating shared resource facility cores use, and educating Center members and trainees on these technologies. Additionally, the ITEMFC will facilitate the transfer of ‘omics data to the Biostatistics and Informatics Facility Core (BIFC). It will accomplish these goals through the following specific aims: Aim 1. Increase access and facilitate use of UofL shared resource facility cores. ITEMFC will serve our members by (a) explaining the various cores and how they operate, (b) establishing direct interactions with the right shared resource director to select the appropriate technology. We will aid in experimental design and closely collaborate with all Facility Cores to streamline sample handling and data analysis. The ITEMFC will also supplement the cost of member studies. Aim 2. Cultivate awareness, interest and understanding of the ITEMFC shared resource facility cores. The ITEMFC will support CIEHS members by (a) drawing attention to the shared resource facility cores, (b) suggesting how the ITEMFC may enhance their approach in answering their research questions, and (c) support educating the next generation of environmental scientists in the various technologies. Aim 3. Facilitate submission of CIEHS members’ grant applications proposing to use ITEMFC Resources. The ITEMFC will support CIEHS members in their grant applications that include ‘omics-based aims. The integrated services and expertise of the ITEMFC are essential to achieve CIEHS goals and to make progress with regard to understanding the diverse pathological consequences of exposure to environmental toxicants together with lifestyle factors.

综合环境健康科学中心 (CIEHS) 的目标是了解生命如何 风格因素与人类健康和疾病中环境毒物的接触相互作用， 增强路易斯维尔大学 (UofL) 的环境健康研究能力。伦敦大学 共享资源设施核心提供尖端科学服务，使人们能够获得高端科学服务 设备、先进技术和专业知识通常是普通人无法获得的 研究者。现代环境健康科学家必须了解众多的 可用的共享资源设施核心；在可访问性、有效的实验设计、数据方面 采集和分析。综合毒理学和环境测量设施核心 (ITEMFC) 将为 CIEHS 成员创建一个中心资源，使他们能够了解、访问和 有效利用环境组学资源。 ITEMFC 将协调 CIEHS 之间的活动 成员和现有伦敦大学共享资源设施核心。 ITEMFC 将由 6 个成员组成 以离散技术为中心的组件：基因组学/转录组学、蛋白质组学、代谢组学、 金属组学、宏基因组学和受控吸入暴露研究。 ITEMFC 将重点关注 努力为研究人员提供研究设计方面的建议，促进共享资源设施核心的使用，以及 对中心成员和学员进行这些技术的教育。此外，ITEMFC 将促进 将组学数据传输到生物统计和信息学设施核心（BIFC）。它将完成 通过以下具体目标实现这些目标： 目标 1. 增加 UofL 的访问和便利使用 共享资源设施核心。 ITEMFC 将通过 (a) 解释各种核心和 他们如何运作，(b) 与正确的共享资源总监建立直接互动以选择 适当的技术。我们将协助实验设计并与所有设施密切合作 简化样品处理和数据分析的核心。 ITEMFC 还将补充以下费用： 会员研究。目标 2. 培养对共享 ITEMFC 的认识、兴趣和理解 资源设施核心。 ITEMFC 将通过 (a) 提请注意 共享资源设施核心，(b) 建议 ITEMFC 如何加强其在 回答他们的研究问题，以及 (c) 支持教育下一代环境工作者 各种技术领域的科学家。目标 3. 促进 CIEHS 成员拨款的提交 建议使用 ITEMFC 资源的应用程序。 ITEMFC 将支持 CIEHS 成员的工作 拨款申请包括“基于组学的目标”。 ITEMFC 的综合服务和专业知识 对于实现 CIEHS 目标以及在理解多元化方面取得进展至关重要 暴露于环境毒物以及生活方式因素的病理后果。