羟氯喹可以预防狼疮妊娠中的先兆子痫和早产吗？-猫眼课题宝

羟氯喹可以预防狼疮妊娠中的先兆子痫和早产吗？

批准号：

10220856

负责人：

Julia F Simard

金额：

$53.12万

依托单位：

STANFORD UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2020

资助国家：

美国

项目状态：

未结题

起止时间：

2020-08-01 至 2025-05-31

来源：

https://reporter.nih.gov/project-details/10220856

关键词：

Accounting Address Adherence Affect Ambulatory Care Antiphospholipid Antibodies Award Behavioral Sciences Benefits and Risks Blindness California Cerebral Palsy Child Clinical Clinical Data Clinical Trials Complication Data Databases Diagnosis Discipline of obstetrics Disease Disease Management Documentation Epidemiologist Epidemiology Female of child bearing age Focus Groups Foundations Funding Future General Population Gestational Diabetes Glucocorticoids Goals Guideline Adherence Heterogeneity Hydroxychloroquine Hypertension Infant Infection Inflammatory International Interruption Intervention Israel Link Lupus Maternal Mortality Mediating Mediation Mediator of activation protein Medical Mentored Research Scientist Development Award Methodology Methods Modification Outcome Oxidative Stress Pathogenesis Patients Pharmaceutical Preparations Pharmacoepidemiology Phenotype Placentation Population Population Study Pre-Eclampsia Pregnancy Pregnant Women Premature Birth Premature Infant Primary Health Care Production Proteinuria Provider Recommendation Research Research Personnel Residual state Rheumatology Risk Selection Bias Serology Stroke Sweden Systemic Lupus Erythematosus Toll-like receptors United States Universities Woman Work adverse outcome adverse pregnancy outcome chronic autoimmune disease clinical care cohort comparative effectiveness study compliance behavior cytokine design early onset effective therapy experience health care availability health care service organization high risk population improved innovation inpatient service lens medical schools multidisciplinary novel parity phenotyping algorithm population based pregnant premature prevent programs provider adherence recruit reproductive working group

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Systemic lupus erythematosus has been linked to excess preeclampsia in pregnancy and preterm delivery, however promising preliminary data suggest that hydroxychloroquine may protect pregnant women with lupus from these potentially catastrophic outcomes. This work leverages three large population-based databases from around the world (United States, Israel, and Sweden) with detailed prescription and clinical data to address threats to internal validity common in pharmacoepidemiological studies such as confounding by indication and selection bias while disentangling these outcomes from the effects of potential mediators such as glucocorticoids and gestational diabetes. Finally, given that hydroxychloroquine is safe and effective in pregnant women with lupus for managing their disease, we will work with patients and providers to understand why pregnant women with lupus are either choosing not to use this medication or are not being prescribed it in the first place.

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