Exposure to PFNA and other PFAS in drinking water and associations with health-related outcomes in Gloucester County NJ

新泽西州格洛斯特县饮用水中 PFNA 和其他 PFAS 的暴露及其与健康相关结果的关联

• 批准号: 10220742
• 负责人: ROBERT John LAUMBACH
• 金额: $ 100万
• 依托单位: RBHS-SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220742
• 关键词: Exposure; PFNA; other; PFAS; drinking

PROJECT SUMMARY The Agency for Toxic Substances and Disease Registry (ATSDR) has identified the need for additional epidemiological research on the health effects of poly- and perfluoroalkyl substances (PFAS) exposures, particularly from contaminated drinking water and for compounds even less studied than perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), such as perfluorononanoic acid (PFNA). The highest levels of PFNA contamination in public and private water wells recorded anywhere in the world were found in Paulsboro and West Deptford New Jersey, where measurable levels of other poly- and perfluoroalkyl substances (PFAS) were also detected. Contaminated drinking water is an important and growing source of exposure to PFNA and other PFAS, and it estimated that millions of adults and children are exposed to PFAS in drinking water. Associations between serum PFAS levels in the general population and a wide range of health effects have been reported, but relatively little is known about health effects from consuming water contaminated with PFAS. There is a critical need to better understand the health hazards and risks of PFNA and other PFAS in drinking water. The main objective of this proposal is to evaluate associations between health outcomes and multiple estimates of exposure to PFNA and other PFAS among members of these communities and the other study sites in a multi-site study. A number of hypotheses will be tested, including that exposure to PFNA and other PFAS are associated with blood lipid levels, renal function and kidney disease, thyroid hormones and disease, liver function and disease, glycemic parameters and diabetes, and immune response and function in both children and adults. Additional hypothesized effects to be studied include differences in sex hormones and sexual maturation, vaccine response, and neurobehavioral outcomes in children, as well as cardiovascular disease, osteoarthritis and osteoporosis, endometriosis, and autoimmune disease in adults. The rationale for these multiple cross-sectional analyses is to test hypotheses for which there is sufficient statistical power based on prior reports, to develop new hypotheses, and to build a foundation for future knowledge generation with members of these communities. As part of the multi-site study with a target enrollment of 6,000 adults and 2000 children, 1,000 adults and 350 children from the Paulsboro and West Deptford municipalities who consumed water from wells contaminated with PFNA and other PFAS will be enrolled. Assessment of exposure to PFAS will be based on blood concentrations of PFAS and drinking water exposure reconstruction and PBPK modeling of internal exposure, including development of novel models for PFNA. Estimation of associations between health outcomes and measured and modeled exposure to PFAS will be done for this site and across sites of this multi-site study. The proposed project is relevant to public health, because our results will strengthen the evidence basis for making decisions about policies and actions to protect human health when people may be exposed to PFAS from drinking water.

项目摘要 有毒物质和疾病登记署（ATSDR）已确定需要增加 关于接触多氟烷基和全氟烷基物质对健康影响的流行病学研究， 特别是受污染的饮用水，以及比全氟辛酸更少研究的化合物 全氟辛烷磺酸（PFOS），例如全氟壬酸（PFNA）。最高层 在世界任何地方记录的公共和私人威尔斯水井中发现了PFNA污染， Paulsboro和West德特福德新泽西，在这些地区， 还检测到了PFAS物质。受污染的饮用水是一个重要的和不断增长的来源， 暴露于PFNA和其他PFAS，估计有数百万成人和儿童暴露于PFAS 在饮用水中。一般人群血清PFAS水平与多种疾病之间的相关性 对健康的影响已有报道，但对饮用水对健康的影响知之甚少 被PFAS污染迫切需要更好地了解PFNA的健康危害和风险 和其他PFAS在饮用水中。本提案的主要目的是评估 这些组织成员的健康结果以及对PFNA和其他PFAS暴露的多项估计 社区和其他研究中心进行多中心研究。一些假设将被测试，包括 暴露于PFNA和其他PFAS与血脂水平、肾功能和肾功能相关， 疾病、甲状腺激素和疾病、肝功能和疾病、血糖参数和糖尿病，以及 儿童和成人的免疫反应和功能。待研究的其他假设效应 包括性激素和性成熟、疫苗反应和神经行为结果差异 在儿童中，以及心血管疾病、骨关节炎和骨质疏松症、子宫内膜异位症和自身免疫性 成年人的疾病。这些多个横断面分析的基本原理是检验假设， 有足够的统计力量，根据以前的报告，发展新的假设，并建立一个 与这些社区的成员一起为未来的知识生成奠定基础。作为多中心研究的一部分 目标入学人数为6,000名成人和2000名儿童，1,000名成人和350名儿童来自保罗博罗 和西德特福德市，他们饮用了被PFNA和其他PFAS污染的威尔斯井水 将被录取。对PFAS暴露的评估将基于PFAS的血液浓度和饮用 水暴露重建和内部暴露的PBPK建模，包括开发新的 PFNA的模型。估计健康结果与测量和模拟暴露之间的关联 将对本研究中心和本多中心研究的各研究中心进行PFAS。拟议项目涉及 公共卫生，因为我们的研究结果将加强决策的证据基础， 当人们可能从饮用水中暴露于PFAS时，应采取行动保护人类健康。