HIV Clinical Tumor Biorepository (HTCB) Core

翻译后摘要：HCTB核心将协助PJIs与他们有前途的研究应用到临床领域 病毒肿瘤学，通过优先考虑临床数据和生物标本收集，为PJI中心 转化病毒肿瘤学（CTVO）。CTVO将支持核心人员，他们将为以下方面提供服务： PJI免费这个独特的HIV/临床肿瘤生物储存库（HCTB）由Dr. 帕森斯从艾滋病毒/艾滋病预防计划和其他肿瘤诊所收集生物标本， 评估、诊断和治疗病毒相关恶性肿瘤患者。这些患者的 少数民族的比例过高，主要是非洲裔美国人。我们的首要目标是协助PJIs 通过利用相关生物标本和临床数据进行高质量的转化研究， 在新奥尔良大学医学中心-传染病中心（UMCNO）接受治疗的患者， 国际数据中心）及其附属伙伴（艾滋病毒/艾滋病防治方案和其他）。使用这些样本将告知 并确保其机制研究的临床相关性，促进其工作的临床转化。 通过这一努力，我们寻求在未来改善缺乏服务的艾滋病毒+患者的健康结果， 病毒相关的癌症此外，获得这些独特的样品应该为成功的PJI提供 竞争优势，因为他们申请独立赠款资金。HCTB核心将支持翻译 PJIs在CTVO中提出的研究，具体目标如下：1）协助PJIs进行IRB 转化研究的应用和设计; 2）扩大一个综合的，以临床为基础的收集系统 来自新奥尔良HIV阳性患者的相关临床数据和生物标本，这些患者具有感染病毒的高风险- 3）确保储存高质量的艾滋病毒+生物标本，以便PJIs获取;以及4） 及时将HIV+生物标本运送给PJI的外部合作者。

Abstract: The HCTB Core will assist PJIs with the application of their promising research to the field of clinical viral oncology through prioritization of clinical data and biospecimen collection for PJIs in the Center for Translational Viral Oncology (CTVO). The CTVO will support personnel in the Core who will provide services to the PJIs at no cost. This unique HIV/Clinical Tumor Biorepository (HCTB) organized and directed by Dr. Parsons collects biospecimens from the HIV/AIDS Malignancy Program and from other oncology clinics that evaluate, diagnose and treat patients with viral associated malignancies. These patients have a disproportionate representation of minorities, mostly African American. Our overarching goal is to assist PJIs with performance of high-quality translational research utilizing linked biospecimens and clinical data from patients receiving care at the University Medical Center – New Orleans - Infectious Diseases Center (UMCNO- IDC) and its affiliated partners (HIV/AIDS Malignancy Program and others). Use of these samples will inform and ensure clinical relevance for their mechanistic studies and promote clinical translation of their work. Through this effort, we seek in the future to improve health outcomes for underserved HIV+ patients at risk for virus-associated cancers. In addition access to these unique samples should provide successful PJI's with a competitive edge as they apply for independent grant funding. The HCTB Core will support the translational research proposed by PJIs in the CTVO through the following Specific Aims: 1) To assist PJIs with IRB applications and design of translational studies; 2) To expand an integrated, clinic-based system for collection of linked clinical data and biospecimens from HIV+ patients in New Orleans who are at high risk for virus- associated cancers; 3) To ensure storage of high-quality HIV+ biospecimens for easy access by PJIs; and 4) To perform timely shipment of HIV+ biospecimens to external collaborators for PJIs.