HIV Clinical Tumor Biorepository (HTCB) Core

摘要：HCTB 核心将协助 PJI 将其有前景的研究应用于临床领域 通过优先考虑中心的 PJI 临床数据和生物样本收集来进行病毒肿瘤学研究 转化病毒肿瘤学（CTVO）。 CTVO 将支持核心人员，为以下人员提供服务： 免费获取 PJI。这个独特的 HIV/临床肿瘤生物样本库 (HCTB) 由 Dr. 帕森斯从艾滋病毒/艾滋病恶性肿瘤计划和其他肿瘤诊所收集生物样本 评估、诊断和治疗患有病毒相关恶性肿瘤的患者。这些患者有一个 少数族裔（主要是非裔美国人）的代表性过高。我们的首要目标是协助 PJI 利用链接的生物样本和临床数据进行高质量的转化研究 在新奥尔良大学医学中心传染病中心（UMCNO-）接受护理的患者 IDC）及其附属合作伙伴（艾滋病毒/艾滋病恶性肿瘤计划等）。使用这些样本将告知 确保其机制研究的临床相关性并促进其工作的临床转化。 通过这一努力，我们未来寻求改善服务不足、面临感染风险的艾滋病毒患者的健康结果 病毒相关的癌症。此外，获得这些独特的样本还可以为成功的 PJI 提供 他们申请独立拨款资金时具有竞争优势。 HCTB 核心将支持转化 PJI 在 CTVO 中提出的研究通过以下具体目标： 1) 协助 PJI 进行 IRB 转化研究的应用和设计； 2) 扩大基于临床的综合收集系统 来自新奥尔良艾滋病毒患者的相关临床数据和生物样本，这些患者感染病毒的风险很高 相关癌症； 3) 确保储存高质量的 HIV 生物样本，以便 PJI 轻松获取；和 4) 及时将 HIV 生物样本运送给 PJI 的外部合作者。

Abstract: The HCTB Core will assist PJIs with the application of their promising research to the field of clinical viral oncology through prioritization of clinical data and biospecimen collection for PJIs in the Center for Translational Viral Oncology (CTVO). The CTVO will support personnel in the Core who will provide services to the PJIs at no cost. This unique HIV/Clinical Tumor Biorepository (HCTB) organized and directed by Dr. Parsons collects biospecimens from the HIV/AIDS Malignancy Program and from other oncology clinics that evaluate, diagnose and treat patients with viral associated malignancies. These patients have a disproportionate representation of minorities, mostly African American. Our overarching goal is to assist PJIs with performance of high-quality translational research utilizing linked biospecimens and clinical data from patients receiving care at the University Medical Center – New Orleans - Infectious Diseases Center (UMCNO- IDC) and its affiliated partners (HIV/AIDS Malignancy Program and others). Use of these samples will inform and ensure clinical relevance for their mechanistic studies and promote clinical translation of their work. Through this effort, we seek in the future to improve health outcomes for underserved HIV+ patients at risk for virus-associated cancers. In addition access to these unique samples should provide successful PJI's with a competitive edge as they apply for independent grant funding. The HCTB Core will support the translational research proposed by PJIs in the CTVO through the following Specific Aims: 1) To assist PJIs with IRB applications and design of translational studies; 2) To expand an integrated, clinic-based system for collection of linked clinical data and biospecimens from HIV+ patients in New Orleans who are at high risk for virus- associated cancers; 3) To ensure storage of high-quality HIV+ biospecimens for easy access by PJIs; and 4) To perform timely shipment of HIV+ biospecimens to external collaborators for PJIs.