Training Program for Applied Research and Development in Genomic Medicine

基因组医学应用研究与开发培训计划

• 批准号: 10224446
• 负责人: JULIE A. JOHNSON
• 金额: $ 7.98万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224446
• 关键词: Applied Research; Genomic medicine; Training Programs; research and development

Abstract Healthcare professionals, scientists, and the public are embracing the potential advances in healthcare that are possible, and in some cases being delivered now, through approaches that employ genomic and other personal information to improve care. To ensure these expectations become reality requires a highly qualified cadre of clinician-scientists, scientists and clinicians working collaboratively to advance discoveries and implementation in genomic medicine. We propose a new post-doctoral genomic medicine training program called “Program for Applied Research and Development in Genomic Medicine or PARADIGM”. This training program for MDs, PharmDs, other clinical specialists at the doctoral level, and PhDs is based on four premises: Genomic medicine: 1. will be led primarily by doctorally-trained clinicians and a team approach is essential. 2. needs clinical translational scientists in with core competencies in translational science, and specialized knowledge in genomic medicine. 3. will require leaders, and this program will foster development of leadership and professionalism. 4. will improve lives through scientific leaders in academia, healthcare, the private sector, governmental regulatory science and policy, among other sectors. To train individuals to meet these needs, PARADIGM will provide up to 4 post-doctoral scholars a multi-year, integrated, multidisciplinary program to prepare them for a career in genomic medicine. Broadly, the program is comprised of four major components: 1) a Didactic component of required and optional coursework; 2) a Mentored Research component involving a defined research project under the mentorship of an accomplished genomic medicine scientist and clinician; 3) a Clinical Genomic Medicine component that integrates them into the genomic medicine clinical practice setting; and 4) a Professional Development component including experiential training through presenting at national meetings, participating in grant and budget reviews, mentoring students and other activities. The mosaic of training experiences across these four components will be tailored according to the previous experiences, educational needs and research interests of the trainee, but will be concentrated in three cores of expertise at UF: pharmacogenomics, cancer genomics, and disease susceptibility genetics/genomics. We will rely on 36 highly talented, collaborative, multidisciplinary mentors to execute the program. PARADIGM will undergo continuous evaluation and quality improvement to ensure long-term success of the trainees. Upon program completion, each trainee will be expected to possess knowledge and skills that will enable them to manage the challenges of evidence generation and clinical use of genomic medicine.

摘要 医疗保健专业人员，科学家和公众正在接受医疗保健的潜在进步 在某些情况下，通过使用基因组技术的方法， 和其他个人信息，以改善护理。为了确保这些期望成为现实， 由临床科学家、科学家和临床医生组成的高素质骨干队伍， 推进基因组医学的发现和实施。我们建议一个新的博士后 基因组医学培训计划，称为“应用研究和发展计划， 基因组医学或Paradigm。本培训计划为医学博士，药学博士，其他临床专家 在博士水平，博士学位是基于四个前提：基因组医学：1。将主要由 训练有素的临床医生和团队方法至关重要。2.需要临床转化科学家， 拥有转化科学的核心竞争力和基因组医学的专业知识。3. 将需要领导者，这一计划将促进领导能力和专业精神的发展。4.将 通过学术界、医疗保健、私营部门、政府部门的科学领导者改善生活 监管科学和政策等部门。为了培训个人以满足这些需求， PARADIGM将提供多达4个博士后学者一个多年的，综合的，多学科的 该计划旨在为他们在基因组医学领域的职业生涯做好准备。总的来说，该计划由四个部分组成 主要组成部分：1）必修和选修课程的教学部分; 2）指导 研究部分，涉及在一位有成就的专家指导下的一个确定的研究项目。 基因组医学科学家和临床医生; 3）临床基因组医学组件， 他们进入基因组医学临床实践设置;和4）专业发展 组成部分包括通过在国家会议上发言、参加赠款 和预算审查，指导学生和其他活动。培训经历的马赛克 这四个组成部分将根据以往的经验、教育需求和 和研究兴趣的受训者，但将集中在三个核心的专业知识在用友： 药物基因组学、癌症基因组学和疾病易感性遗传学/基因组学。我们将依靠 36位才华横溢、相互协作、多学科的导师来执行该计划。范式将 不断进行评估和质量改进，以确保学员的长期成功。 在计划完成后，每个受训者将被期望拥有的知识和技能， 使他们能够应对证据生成和基因组医学临床应用的挑战。