Training Program for Applied Research and Development in Genomic Medicine

基因组医学应用研究与开发培训计划

• 批准号: 10224446
• 负责人: JULIE A. JOHNSON
• 金额: $ 7.98万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224446
• 关键词: Applied Research; Genomic medicine; Training Programs; research and development

Abstract Healthcare professionals, scientists, and the public are embracing the potential advances in healthcare that are possible, and in some cases being delivered now, through approaches that employ genomic and other personal information to improve care. To ensure these expectations become reality requires a highly qualified cadre of clinician-scientists, scientists and clinicians working collaboratively to advance discoveries and implementation in genomic medicine. We propose a new post-doctoral genomic medicine training program called “Program for Applied Research and Development in Genomic Medicine or PARADIGM”. This training program for MDs, PharmDs, other clinical specialists at the doctoral level, and PhDs is based on four premises: Genomic medicine: 1. will be led primarily by doctorally-trained clinicians and a team approach is essential. 2. needs clinical translational scientists in with core competencies in translational science, and specialized knowledge in genomic medicine. 3. will require leaders, and this program will foster development of leadership and professionalism. 4. will improve lives through scientific leaders in academia, healthcare, the private sector, governmental regulatory science and policy, among other sectors. To train individuals to meet these needs, PARADIGM will provide up to 4 post-doctoral scholars a multi-year, integrated, multidisciplinary program to prepare them for a career in genomic medicine. Broadly, the program is comprised of four major components: 1) a Didactic component of required and optional coursework; 2) a Mentored Research component involving a defined research project under the mentorship of an accomplished genomic medicine scientist and clinician; 3) a Clinical Genomic Medicine component that integrates them into the genomic medicine clinical practice setting; and 4) a Professional Development component including experiential training through presenting at national meetings, participating in grant and budget reviews, mentoring students and other activities. The mosaic of training experiences across these four components will be tailored according to the previous experiences, educational needs and research interests of the trainee, but will be concentrated in three cores of expertise at UF: pharmacogenomics, cancer genomics, and disease susceptibility genetics/genomics. We will rely on 36 highly talented, collaborative, multidisciplinary mentors to execute the program. PARADIGM will undergo continuous evaluation and quality improvement to ensure long-term success of the trainees. Upon program completion, each trainee will be expected to possess knowledge and skills that will enable them to manage the challenges of evidence generation and clinical use of genomic medicine.

抽象的 医疗保健专业人士、科学家和公众正在拥抱医疗保健领域的潜在进步 这是可能的，并且在某些情况下现在正在通过采用基因组的方法来实现 以及其他个人信息以改善护理。为了确保这些期望成为现实需要 一支由临床医生-科学家、科学家和临床医生组成的高素质骨干队伍，通力合作， 基因组医学的先进发现和实施。我们提议一名新的博士后 基因组医学培训计划称为“应用研究与开发计划” 基因组医学或 PARADIGM”。该培训计划针对医学博士、药学博士和其他临床专家 在博士级别，博士学位基于四个前提： 基因组医学： 1. 将主要由 经过医生培训的临床医生和团队合作至关重要。 2. 需要临床转化科学家 拥有转化科学的核心能力和基因组医学的专业知识。 3. 将需要领导者，该计划将促进领导力和专业精神的发展。 4. 会 通过学术界、医疗保健、私营部门、政府的科学领导者改善生活 监管科学和政策等部门。为了培训个人满足这些需求， PARADIGM将为最多4名博士后学者提供多年、综合、多学科的机会 计划为他们在基因组医学领域的职业生涯做好准备。总体而言，该计划由四个部分组成 主要组成部分：1）必修和可选课程的教学部分； 2) 指导 研究部分涉及在有成就的人的指导下确定的研究项目 基因组医学科学家和临床医生； 3) 临床基因组医学组件，集成了 他们进入基因组医学临床实践环境； 4) 专业发展 组成部分包括通过在国家会议上发言、参与赠款进行体验式培训 预算审查、指导学生和其他活动。培训经历的马赛克 这四个组成部分将根据以前的经验、教育需求进行定制 和受训者的研究兴趣，但将集中在佛罗里达大学的三个核心专业知识上： 药物基因组学、癌症基因组学和疾病易感性遗传学/基因组学。我们将依靠 36 位才华横溢、善于协作、多学科的导师来执行该计划。范式将 接受持续的评估和质量改进，以确保学员的长期成功。 计划完成后，每位学员都应具备能够满足以下要求的知识和技能： 使他们能够应对基因组医学证据生成和临床应用的挑战。