Mechanisms of spontaneous and vaccine mediated hepatitis C virus control to direct rational development of a novel HCV vaccine
自发和疫苗介导的丙型肝炎病毒控制机制指导新型丙型肝炎疫苗的合理开发
基本信息
- 批准号:10398149
- 负责人:
- 金额:$ 47.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-01 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAcute Hepatitis CAliquotAnimalsAntibodiesAntibody ResponseAntibody titer measurementBindingBiological AssayBiological Specimen BanksBloodBlood Component RemovalCellsClinicalCodeCollectionCounselingDevelopmentElementsEnrollmentEnsureEnzyme-Linked Immunosorbent AssayExperimental ModelsFundingFutureGenotypeGoalsGrantHarm ReductionHepatitis CHepatitis C AntibodiesHepatitis C IncidenceHepatitis C VaccineHepatitis C virusHumanImmune responseImmunityInfectionInfrastructureInjecting drug userLocationLymphocyteMacacaMeasurementMeasuresMediatingMediator of activation proteinMonitorMonoclonal AntibodiesMusNeutralization TestsOutcomeParticipantPeripheral Blood Mononuclear CellPersonsPharmacotherapyPhasePhylogenetic AnalysisPlasmaPopulationRNARecoveryRecurrenceResearchResearch PersonnelResourcesRiskSamplingScientistSerology testSerumSpecimenStandardizationTestingTimeUnited States National Institutes of HealthVaccinatedVaccinationVaccinesViremiaVirusVisitacute infectionchronic infectionclinical careclinically relevantcohortdesignefficacy trialenv Gene Productsexperimental studyhigh riskimmunogenicityin vivoinfection riskinjection drug usenonhuman primatenoveloutreachprophylacticprospectiverecruitrepositoryresponsescreeningseroconversionsuccesstreatment programvaccine candidatevaccine evaluationvaccine-induced antibodies
项目摘要
Scientific Core (Core B) Project Summary
The Scientific Core is designed to successfully recruit and monitor HCV-antibody-negative people who inject
drugs (PWID) for HCV infection and to identify and characterize acute infections and reinfections by testing
sera for HCV RNA and seroconversion with serial ALT and HCV RNA testing. The infrastructure of Core B was
necessary for completion of the first trial of an HCV vaccine in people at risk of HCV infection and will be useful
in potential future trials of HCV vaccines. Plasma, serum, and peripheral blood mononuclear cells will be
collected from prior to infection, during infection, and through the time when infection outcome (clearance or
persistence of virus as well as during reinfection. Samples are stored in the repository for use in Projects 1-4,
as well as for other HCV investigators. Core B will also provide standardized serological testing to quantitate
HCV envelope-specific antibodies in plasma or serum of humans or vaccinated animals. Quantitative analyses
of vaccine-induced plasma or serum antibody responses are essential to identify the most promising vaccine
candidates. By applying a standardized set of assays to samples post-vaccination and from humans who
successfully cleared multiple HCV infections, we will be able to make quantitative and qualitative comparisons
between vaccine-induced antibody responses in mice or nonhuman primates (Projects 3 and 5) and human
responses that are protective against HCV in vivo (Project 2). This will facilitate identification the vaccines most
likely to be protective when advanced to human trials.
科学核心(核心B)项目摘要
Science Core旨在成功招募和监控注射丙型肝炎病毒抗体阴性的人
治疗丙型肝炎病毒感染的药物(PWID),并通过检测来识别和表征急性感染和再感染
血清进行丙型肝炎病毒核糖核酸检测和血清转换及丙氨酸氨基转移酶和丙型肝炎病毒核糖核酸检测。核心B的基础设施是
对于完成丙型肝炎病毒感染风险人群的丙型肝炎疫苗的第一次试验是必要的,并且将是有用的
在未来潜在的丙型肝炎疫苗试验中。血浆、血清和外周血单核细胞将
收集自感染前、感染期间和感染发生时(清除或
病毒的持久性以及在再次感染期间。样本存储在储存库中以在项目1-4中使用,
以及其他丙型肝炎病毒研究人员。核心B还将提供标准化的血清学检测,以量化
人或接种疫苗的动物的血浆或血清中的丙型肝炎病毒包膜特异性抗体。定量分析
疫苗诱导的血浆或血清抗体反应是确定最有希望的疫苗的关键
候选人。通过将一套标准化的化验应用于疫苗接种后的样本和来自
成功清除多个丙型肝炎病毒感染,我们将能够进行定量和定性比较
疫苗在小鼠或非人灵长类动物中诱导的抗体反应(项目3和5)与人类之间的关系
体内对丙型肝炎病毒具有保护性的反应(项目2)。这将最有利于疫苗的鉴定
很可能在进入人体试验时起到保护作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANDREA L COX其他文献
ANDREA L COX的其他文献
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{{ truncateString('ANDREA L COX', 18)}}的其他基金
Mechanisms of spontaneous and vaccine mediated hepatitis C virus control to direct rational development of a novel HCV vaccine
自发和疫苗介导的丙型肝炎病毒控制机制指导新型丙型肝炎疫苗的合理开发
- 批准号:
10614971 - 财政年份:2021
- 资助金额:
$ 47.33万 - 项目类别:
Mechanisms of spontaneous and vaccine mediated hepatitis C virus control to direct rational development of a novel HCV vaccine
自发和疫苗介导的丙型肝炎病毒控制机制指导新型丙型肝炎疫苗的合理开发
- 批准号:
10205729 - 财政年份:2021
- 资助金额:
$ 47.33万 - 项目类别:
Mechanisms of spontaneous and vaccine mediated hepatitis C virus control to direct rational development of a novel HCV vaccine
自发和疫苗介导的丙型肝炎病毒控制机制指导新型丙型肝炎疫苗的合理开发
- 批准号:
10205731 - 财政年份:2021
- 资助金额:
$ 47.33万 - 项目类别:
Immunologic and Metabolic Profiles of T cells that control diverse HCV infections
控制多种 HCV 感染的 T 细胞的免疫学和代谢特征
- 批准号:
10398150 - 财政年份:2021
- 资助金额:
$ 47.33万 - 项目类别:
Sex, obesity, immunometabolism, and viral persistence in post-acute sequelae of SARS-CoV-2 infection
SARS-CoV-2 感染急性后遗症中的性别、肥胖、免疫代谢和病毒持续性
- 批准号:
10554731 - 财政年份:2021
- 资助金额:
$ 47.33万 - 项目类别:
Mechanisms of spontaneous and vaccine mediated hepatitis C virus control to direct rational development of a novel HCV vaccine
自发和疫苗介导的丙型肝炎病毒控制机制指导新型丙型肝炎疫苗的合理开发
- 批准号:
10205730 - 财政年份:2021
- 资助金额:
$ 47.33万 - 项目类别:
Mechanisms of spontaneous and vaccine mediated hepatitis C virus control to direct rational development of a novel HCV vaccine
自发和疫苗介导的丙型肝炎病毒控制机制指导新型丙型肝炎疫苗的合理开发
- 批准号:
10398147 - 财政年份:2021
- 资助金额:
$ 47.33万 - 项目类别:
Mechanisms of spontaneous and vaccine mediated hepatitis C virus control to direct rational development of a novel HCV vaccine
自发和疫苗介导的丙型肝炎病毒控制机制指导新型丙型肝炎疫苗的合理开发
- 批准号:
10398148 - 财政年份:2021
- 资助金额:
$ 47.33万 - 项目类别:
Mechanisms of spontaneous and vaccine mediated hepatitis C virus control to direct rational development of a novel HCV vaccine
自发和疫苗介导的丙型肝炎病毒控制机制指导新型丙型肝炎疫苗的合理开发
- 批准号:
10671902 - 财政年份:2021
- 资助金额:
$ 47.33万 - 项目类别:
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自发性急性丙型肝炎病毒消退的生物标志物
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