The Environmental Determinants of Diabetes in the Young (TEDDY) Study, Washington Clinical Center

年轻糖尿病的环境决定因素 (TEDDY) 研究，华盛顿临床中心

• 批准号: 10225406
• 负责人: William A. Hagopian
• 金额: $ 66.25万
• 依托单位: PACIFIC NORTHWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10225406
• 关键词: 15 year old; 6 year old; Affect; Age; Ancillary Study; Autoantibodies; Autoimmune Diseases; Big Data; Biological; Biological Specimen Banks; Celiac Disease; Child; Child Development; Clinical Investigator; Collection; Colorado; Communities; Complement; Country; DNA; Data; Data Analyses; Data Collection; Data Set; Development; Diabetes Mellitus; Diabetes prevention; Diagnosis; Dietary Factors; Disease; Enrollment; Environmental Exposure; Environmental Risk Factor; Epigenetic Process; Etiology; Europe; Feces; Finland; Florida; Foundations; Genetic; Genetic Variation; Genotype; Germany; Goals; HLA-DR Antigens; Heterogeneity; Individual; Infection; Infectious Agent; Insulin-Dependent Diabetes Mellitus; Knowledge; Laboratories; Laboratory Study; National Institute of Diabetes and Digestive and Kidney Diseases; Nested Case-Control Study; Newborn Infant; Outcome Study; Participant; Pathogenesis; Performance; Peripheral Blood Mononuclear Cell; Plasma; Play; Prevention strategy; Prospective cohort study; Proteomics; Protocols documentation; Publications; RNA; Research Design; Research Personnel; Resources; Risk; Sampling; Science; Scientist; Serum; Solid; Specimen; Standardization; Supervision; Sweden; Testing; Time; United States; United States National Institutes of Health; Washington; Work; autoimmune thyroid disease; biomarker development; clinical center; cohort; design; diabetes pathogenesis; diabetes risk; dietary; endocrine pancreas development; epidemiologic data; follow-up; gene environment interaction; high risk; individualized prevention; infancy; insight; islet autoimmunity; islet cell antibody; metabolomics; multiple omics; nasal swab; novel; prevent; promoter; prospective; repository; transcriptomics

PROJECT SUMMARY/ABSTRACT The Environmental Determinants of Diabetes in the Young (TEDDY) study was initiated in 2003 by six clinical centers in the United States and Europe, including ours, to identify infectious agents, dietary factors, or other environmental exposures that may trigger or protect against the development of islet autoimmunity and type 1 diabetes (T1D). Additional long-term scientific goals include assessment of potential gene-environment interactions affecting development of islet autoimmunity or T1D, gaining insight on triggering mechanisms through detailed multi-omics analyses, and sharing collected specimens with broader scientific community for studies of T1D pathogenesis and prevention. A total of 424,788 newborns were screened by HLA-DR,DQ genotyping to identify children at increased risk for T1D and 8,676 enrolled for quarterly follow-up until age 4 and semi-annually thereafter until age 15. Now, 13 years after enrollment began, 5731 (66%) remain actively engaged in the protocol. Our Washington State Clinical Center enrolled 1,376 TEDDY participants. As of 2/28/18, 83 of those have developed persistent confirmed islet autoantibodies and 29 have been diagnosed with T1D. Detailed analyses of biological samples from the entire cohort, along with even more comprehensive multi- omics analyses in selected individuals, will provide a rich dataset to complement the intensive collection of exposure data and highly efficient ascertainment of islet autoimmunity and T1D endpoints in the entire cohort. Specific aims of this renewal application for this multi-center, prospective cohort study for the next 5 years are: 1. Follow the TEDDY cohort of high-risk children for development of islet autoimmunity, diabetes, celiac disease and autoimmune thyroid disease until 15 years of age; collect biological specimens and epidemiological data according to the study protocol. 2. Characterize genetic, epigenetic, transcriptomic, proteomic and metabolomic determinants of islet autoimmunity and T1D in the study participants. 3. Prospectively assess infectious, dietary and other environmental exposures of study participants, as triggers of islet autoimmunity and/or promotors of progression to T1D. A successful study outcome will provide a dataset unprecedented in depth and breadth, to help elucidate specific exposures and mechanisms serving in the etiology and pathogenesis of islet autoimmunity, T1D, and closely related autoimmune diseases. The results will support the development of new strategies to prevent, delay, or reverse the disease.

项目总结/文摘