Improving Retention in Care for Adolescents and Young Adults in Kenya: Implementation Science to Support Adaptation and Integration of a Stepped Care Intervention

提高肯尼亚青少年和年轻人的护理保留率：实施科学以支持阶梯式护理干预措施的适应和整合

• 批准号: 10402611
• 负责人: Nok Chhun
• 金额: $ 4.61万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-16 至 2025-06-15
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10402611
• 关键词: Address; Adolescent; Adolescent and Young Adult; Adoption; Adult; Africa South of the Sahara; Area; Caring; Characteristics; Client; Clinical; Consolidated Framework for Implementation Research; Data; Development; Effectiveness of Interventions; Eligibility Determination; Ensure; Evaluation; Evidence based intervention; Failure; Feedback; Focus Groups; Frequencies; Future; Goals; HIV; HIV Infections; HIV-infected adolescents; Health Personnel; Health Services; Health care facility; Health system; Healthcare Systems; Individual; Intervention; Interview; Kenya; Measures; Methodology; Methods; Modeling; Modification; Nature; Outcome; Parents; Penetration; Perception; Persons; Phase; Procedures; Process; Qualitative Methods; Randomized Controlled Trials; Readiness; Recommendation; Reporting; Research; Research Personnel; Resource-limited setting; Resources; Risk; Service delivery model; Services; Surveys; Testing; Time; Time Series Analysis; Training; Treatment outcome; Variant; Viral; Youth; community based care; doctoral student; effectiveness evaluation; evidence base; follow-up; health care settings; high-risk adolescents; implementation determinants; implementation evaluation; implementation facilitators; implementation intervention; implementation outcomes; implementation science; implementation strategy; improved; meetings; model design; mortality; post intervention; pre-doctoral; preference; risk prediction; routine practice; scale up; service delivery; skills; social; success; tool; treatment adherence; trend

Abstract Worldwide, five million adolescents and young adults (AYA) are living with HIV. More than 90% of global HIV- related mortality among AYA occurs in sub-Saharan Africa. A limited but growing evidence base of interventions available for adolescents in sub-Saharan Africa highlight the importance of retention in care for improving treatment outcomes. To meet AYA where they are in their engagement with the healthcare system, interventions need to be feasible, acceptable, and appropriate for local healthcare settings and practice. This F31 project leverages a cluster randomized controlled trial, Data-informed Stepped Care to Improve Adolescent HIV Outcomes (UG3/UH3 HD096906; PIs: Kohler, John-Stewart) that is testing a Stepped Care intervention to improve retention among adolescents and young adults living with HIV in western Kenya. This F31 project aims to evaluate early phase implementation outcomes of the Stepped Care intervention as it is delivered across 10 healthcare facilities. Aim 1 will identify adaptations made to the intervention (materials, procedures, or delivery) that influence acceptability, feasibility, and appropriateness. The Framework for Reporting Adaptations and Modifications to Evidence-based interventions (FRAME) will be used to characterize adaptations and modifications necessary for facility-specific optimization of the intervention. Aim 2 will identify the barriers and facilitators that impact penetration, coverage, and fidelity of the Stepped Care intervention. We will apply the Consolidated Framework for Implementation Research (CFIR) to examine barriers and facilitators of implementation to understand the context and intervention characteristics influencing implementation of the Stepped Care intervention. Finally, Aim 3 will match barriers to successful implementation to targeted strategies to overcome them, producing a package of intervention implementation options that promote long-term intervention adoption and sustainability. Findings from this project will contribute to understanding optimization of Stepped Care and provide valuable information about the context necessary for successful scale-up of Stepped Care interventions for adolescents and young adults within Kenya or scale out to other global settings. The research plan will provide the F31 candidate, an implementation science pre-doctoral student, with rigorous training in (1) implementation science conceptual frameworks, models, design and methodology; (2) training in qualitative methods; and (3) content-area expertise regarding evidence-based interventions for adolescents and young adults living with HIV.

摘要