Core E: Clinical Translation Core

核心 E：临床翻译核心

• 批准号: 10227489
• 负责人: SCOTT H DONALDSON
• 金额: $ 20.8万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10227489
• 关键词: Address; Applications Grants; Ascending colon; Basic Science; Bioinformatics; Biology; Biometry; Biopsy; Clinical; Clinical Investigator; Clinical Research; Colonoscopy; Consultations; Curettage procedure; Custom; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Data Analyses; Databases; Disease; Doctor of Philosophy; Drug Kinetics; Endoscopy; Ensure; Epithelial Cells; Esophagus; Exhalation; Funding; Gene Expression; Goals; Human; Image; Institutes; Institution; Intestines; Lung; Magnetic Resonance Imaging; Maintenance; Metagenomics; Molecular; Mucociliary Clearance; Mucous Membrane; Mucous body substance; Nasal Epithelium; Outcome Measure; Pathogenesis; Patients; Pharmaceutical Preparations; Population; Population Control; Procedures; Process; Pulmonary Cystic Fibrosis; Radionuclide Imaging; Rectum; Research; Research Design; Research Personnel; Resources; Sample Size; Sampling; Services; Shotguns; Specimen; Sputum; Stomach; Symptoms; Tissues; Translating; Translational Research; Translations; Upper digestive tract structure; Work; airway inflammation; base; biobank; clinical outcome measures; clinical translation; clinically relevant; cystic fibrosis patients; fundamental research; gastrointestinal; ileum; imaging biomarker; innovation; intestinal epithelium; metabolomics; microbial; microbiota; novel; novel marker; programs; protein expression; repository; research study; respiratory; sample collection; stool sample; tool; treatment center; trial design; ventilation

PROJECT SUMMARY/ABSTRACT The Clinical Translation Core (CTC) supports the UNC RTCC by providing access to human biospecimens, clinical research expertise (including biostatistics, bioinformatics, trial design, and regulatory assistance) and specialized clinical research outcome measures. These functions have supported more than 40 investigators and the conduct of many research studies. In the current application, the CTC focus will shift its focus to research aimed at defining the pathophysiologic basis of GI symptoms and complications in people with cystic fibrosis. Toward this end, new partnerships with experts in GI biology and disease have been formed to meet these scientific challenges. Strategies that maximize capture of precious human samples during both clinically indicated and research procedures will be implemented. Ongoing biostatistical and study design support will be provided, while also continuing to maintain previously developed core functions that support respiratory research.

项目总结/摘要 临床翻译核心（CTC）通过提供对人类的访问来支持CRTCC。 生物样本、临床研究专业知识（包括生物统计学、生物信息学、试验设计和 监管援助）和专门的临床研究结果的措施。这些功能 支持了40多名研究人员和许多研究的开展。在 目前的应用，反恐中心的重点将转移到研究，旨在确定 囊性纤维化患者胃肠道症状和并发症的病理生理学基础。朝向 为此，与胃肠生物学和疾病专家建立了新的伙伴关系， 这些科学挑战。最大限度地捕获珍贵的人类样本的策略， 将实施临床指示和研究程序。正在进行的生物统计学 将提供研究设计支持，同时继续保持以前的 开发了支持呼吸研究的核心功能。