Copper-depleting nanotheranostics for treating triple negative breast cancer

用于治疗三阴性乳腺癌的铜消耗纳米治疗剂

基本信息

  • 批准号:
    10231101
  • 负责人:
  • 金额:
    $ 53.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT Breast cancer is the number two cause of death among all types of cancers in women. The deadliest subtype of breast cancer, triple-negative, carries the highest metastatic risk and poorest outcome due to the resistance to current therapeutic methods. Triple-negative breast cancer (TNBC) is an intrinsically heterogeneous disease. Targeting single biomarker or oncogene often yields unsatisfactory therapeutic outcome in TNBC treatment. To achieve a broader therapeutic benefit, our starting point is copper ion, one critical metal ion that plays irreplaceable roles in a broad range of biochemical reactions. Copper excess in serum and cancerous tissues has been long recognized in breast cancer patients. Dysregulation of copper metalloproteins is found to be involved in uncontrolled growth, invasion, dissemination of cancer cells, angiogenesis and secondary tumor formation at distant sites. Despite the well-recognized importance, successful attempts to treat cancer with copper chelation are rather limited. This project aims to establish a self-reporting copper depletion nanoplatform to effectively deplete copper in TNBC and ultimately inhibit primary tumor progression and metastasis formation. This application is tightly aligned with the program scope of the Innovative Research in Cancer Nanotechnology (IRCN) Initiative with the goal to employ a novel nanotechnology-based approach to understand copper's role in breast cancer biology systematically and to develop a powerful theranostic drug for TNBC patients. We will design copper- depleting nanocomplex with high depleting efficiency, low toxicity and self-reporting function as TNBC theranostics (Aim 1), determine the treatment effect of copper-depleting nanocomplex and identify the therapeutic mechanism in vitro (Aim 2), and define the therapeutic efficacy of copper-depleting nanocomplex for primary and metastatic TNBC tumor models (Aim 3).
摘要

项目成果

期刊论文数量(0)
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科研奖励数量(0)
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Jianghong Rao其他文献

Jianghong Rao的其他文献

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{{ truncateString('Jianghong Rao', 18)}}的其他基金

PET tracer for imaging senescence
用于衰老成像的 PET 示踪剂
  • 批准号:
    10727823
  • 财政年份:
    2023
  • 资助金额:
    $ 53.56万
  • 项目类别:
Targeting apoptotic cells to enhance radiotherapy
靶向凋亡细胞以增强放射治疗
  • 批准号:
    10708827
  • 财政年份:
    2022
  • 资助金额:
    $ 53.56万
  • 项目类别:
Targeting apoptotic cells to enhance radiotherapy
靶向凋亡细胞以增强放射治疗
  • 批准号:
    10538071
  • 财政年份:
    2022
  • 资助金额:
    $ 53.56万
  • 项目类别:
Copper-depleting nanotheranostics for treating triple negative breast cancer
用于治疗三阴性乳腺癌的铜消耗纳米治疗剂
  • 批准号:
    10004020
  • 财政年份:
    2019
  • 资助金额:
    $ 53.56万
  • 项目类别:
Copper-depleting nanotheranostics for treating triple negative breast cancer
用于治疗三阴性乳腺癌的铜消耗纳米治疗剂
  • 批准号:
    10900851
  • 财政年份:
    2019
  • 资助金额:
    $ 53.56万
  • 项目类别:
Copper-depleting nanotheranostics for treating triple negative breast cancer
用于治疗三阴性乳腺癌的铜消耗纳米治疗剂
  • 批准号:
    10413265
  • 财政年份:
    2019
  • 资助金额:
    $ 53.56万
  • 项目类别:
Copper-depleting nanotheranostics for treating triple negative breast cancer
用于治疗三阴性乳腺癌的铜消耗纳米治疗剂
  • 批准号:
    10472523
  • 财政年份:
    2019
  • 资助金额:
    $ 53.56万
  • 项目类别:
Copper-depleting nanotheranostics for treating triple negative breast cancer
用于治疗三阴性乳腺癌的铜消耗纳米治疗剂
  • 批准号:
    10684918
  • 财政年份:
    2019
  • 资助金额:
    $ 53.56万
  • 项目类别:
Beta-lactamase fluorescent probes for bacterial detection
用于细菌检测的 β-内酰胺酶荧光探针
  • 批准号:
    9309417
  • 财政年份:
    2017
  • 资助金额:
    $ 53.56万
  • 项目类别:
Nanoparticle-Based Triple Modality Imaging and Photothermal Therapy of Brain Tumors
基于纳米颗粒的脑肿瘤三模态成像和光热疗法
  • 批准号:
    10000853
  • 财政年份:
    2016
  • 资助金额:
    $ 53.56万
  • 项目类别:

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