Mentorship of Junior Investigators on HEAL-SKOAP

HEAL-SKOAP 初级研究员的指导

• 批准号: 10426755
• 负责人: Claudia Michelle Campbell
• 金额: $ 32.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426755
• 关键词: Adverse effects; Algorithms; Back; Behavioral; Body mass index; COVID-19 pandemic; Caring; Characteristics; Chronic; Clinical; Clinical Trials; Collaborations; Combined Pharmacological and Behavioral Treatment; Coping Skills; Data Coordinating Center; Degenerative polyarthritis; Discipline; Elderly; Environment; Exhibits; Exposure to; Funding; Funding Mechanisms; Goals; Government; Guidelines; Hyaluronic Acid; Individual; Individual Differences; Industry; Injections; Institution; Intervention; Knee Osteoarthritis; Knowledge; Learning; Life Expectancy; Measures; Medical; Medicine; Mental Depression; Mentors; Mentorship; Modeling; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nerve; Nerve Block; Outcome; Pain; Pain management; Patients; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacology; Phase; Phase III Clinical Trials; Phenotype; Physical Function; Plants; Population; Positioning Attribute; Postdoctoral Fellow; Prediction of Response to Therapy; Procedures; Publishing; Radiofrequency Interstitial Ablation; Randomized; Randomized Controlled Trials; Research Personnel; Risk; Running; Sample Size; Scholarship; Scientist; Seeds; Senior Scientist; Shapes; Site; Sleep; Time; Training; United States National Institutes of Health; Universities; Utah; base; behavioral pharmacology; biopsychosocial; career; chronic pain; clinical care; clinical pain; collaborative environment; comparative effectiveness; comparative effectiveness study; compare effectiveness; design; duloxetine; effectiveness research; effectiveness testing; experience; flexibility; follow-up; functional disability; functional outcomes; graduate student; improved; improved functioning; improved outcome; innovation; interest; knee pain; knee replacement arthroplasty; mid-career faculty; model design; multidisciplinary; next generation; non-opioid analgesic; novel; opioid sparing; opioid therapy; opioid use; osteoarthritis pain; pain catastrophizing; pain model; pain outcome; pain reduction; personalized medicine; precision medicine; pressure; psychosocial; randomized trial; recruit; resilience; response; senior faculty; skills training; standard of care; success; tenure track; training opportunity; treatment comparison; treatment response

SUMMARY/ABSTRACT The exodus from academic to careers in industry, government and other sectors has been expedited by the COVID-19 pandemic. Given tight funding pay lines, a shortage and fierce completion for tenured and tenure- track university/academic medical institution positions and a ‘publish or perish’ mindset, more and more graduate students, postdoctoral fellows and even residents are looking to leave academic medicine in the pursuit of more stable and lucrative careers. Junior investigators require support, guidance and training opportunities to plant the seeds to develop into- and retain established pain scientists. Unfortunately the current algorithm for mid-career and senior faculty success does not include developing the next generation of leaders within our challenging field of academic medicine. The current funding mechanism is an outstanding opportunity for mentors to devote time, effort and funds towards junior investigators interested in a career in pain scholarship. The current application seeks to provide protected mentorship-focused time for Dr. Claudia Campbell, an MPI on the ‘SKOAP’ phase III clinical trial. The SKOAP study, a Sequenced-strategy for improving outcomes in people with Knee OsteoArthritis Pain, is a sequential large-scale HEAL Effectiveness Research Network study evaluating conservative and nonsurgical procedural interventions for reducing pain and improving function in patients with KOA. The trial is an excellent platform for the training of junior investigators from varied disciplines. The SKOAP trial is designed to mimic clinical care by first testing the effectiveness of conservative treatment and nonsurgical interventional procedures. This large-scale, pragmatic, comparative-effectiveness study involves comprehensive and innovative approaches that have never before been employed in this context, providing an exciting learning platform in multiple domains, including: a multidisciplinary cadre of investigators conducting the largest randomized trial to date to evaluate behavioral, pharmacologic, and procedural interventions for KOA; a step-care, factorial design model that allows for more than two dozen pair-wise treatment comparisons; phenotyping to improve selection for each therapy (i.e., precision medicine), which is expected to refine outcomes and reduce unnecessary interventions; integration of a psychosocial intervention WITH medication treatment; a novel design; longitudinal follow-up period; personalized medicine approach; an innovative flexible approach to sample size; deep integration into standard of care and the clinical environment; multiple recruitment sites and a collaboration with multiple groups to support the study, including a number of ICs at NIH, primarily NIAMS and NCATS, a Clinical Coordinating Center (at Duke), Data Coordinating Center (at Utah), Recruitment and Retention support (via Vanderbilt and the Duke Call Center) and startup support within Johns Hopkins (Bios/Trials Innovation center), which provide incredibly rich and varied learning opportunities.

总结/摘要 从学术界到工业界，政府和其他部门的职业生涯的外流加速了 2019冠状病毒病大流行。鉴于资金紧张的工资线，短缺和激烈的完成终身和终身- 跟踪大学/学术医疗机构的立场和'出版或灭亡'的心态，越来越多的 研究生，博士后研究员，甚至居民都希望离开学术医学在 追求更稳定、更赚钱的职业。初级调查员需要支持、指导和培训 有机会播下种子，发展成为并留住既定的疼痛科学家。不幸的是 目前的算法为中期职业生涯和高级教师的成功不包括开发下一代 在我们充满挑战的学术医学领域的领导者。目前的供资机制是一个突出的问题， 导师有机会将时间、精力和资金投入到对以下职业感兴趣的初级调查员身上： 疼痛奖学金当前的应用程序旨在为Claudia博士提供受保护的辅导时间 坎贝尔说，他是“SKOAP”III期临床试验的MPI。SKOAP研究，一项针对 改善膝关节骨关节炎疼痛患者的结局，是一项连续的大规模HEAL Effectiveness 研究网络研究评价了减少疼痛的保守和非外科手术干预措施 并改善KOA患者的功能。审判是一个很好的平台， 来自不同学科的研究人员。SKOAP试验旨在模拟临床护理， 保守治疗和非手术介入治疗的有效性。这个大规模的，务实的， 比较效益研究涉及全面和创新的方法， 在这种情况下，提供了一个令人兴奋的学习平台，在多个领域，包括： 多学科的研究人员进行了迄今为止最大的随机试验， KOA的药物和程序干预;一个阶梯式护理，析因设计模型，允许更多 超过24个成对治疗比较;表型分析以改善每种疗法的选择（即， 精准医学），预计将改善结果并减少不必要的干预; 心理社会干预与药物治疗;一种新的设计;纵向随访期; 个性化医疗方法;创新灵活的样本量方法;深度整合 护理标准和临床环境;多个招募地点和与多个 支持这项研究的小组，包括NIH的一些IC，主要是NIAMS和NCATS，临床研究小组， 协调中心（位于杜克）、数据协调中心（位于犹他州）、招募和保留支持（通过 范德比尔特和杜克呼叫中心）和约翰霍普金斯（生物/试验创新中心）内的启动支持， 提供了非常丰富多样的学习机会。

项目成果

Perioperative insomnia trajectories and functional outcomes after total knee arthroplasty.

全膝关节置换术后围手术期失眠轨迹和功能结果。

• DOI: 10.1097/j.pain.0000000000002977
• 发表时间: 2023
• 期刊: Pain
• 影响因子: 7.4
• 作者: Hamilton,KatrinaR;Hughes,AbbeyJ;Campbell,ClaudiaM;Owens,MichaelA;Pester,BethanyD;Meints,SamanthaM;Taylor,JanieceL;Edwards,RobertR;Haythornthwaite,JenniferA;Smith,MichaelT
• 通讯作者: Smith,MichaelT

Multicenter study evaluating factors associated with treatment outcome for low back pain injections.

• DOI: 10.1136/rapm-2021-103247
• 发表时间: 2022-02
• 期刊: REGIONAL ANESTHESIA AND PAIN MEDICINE
• 影响因子: 5.1
• 作者: Cohen, Steven P.;Doshi, Tina L.;Kurihara, Connie;Reece, David;Dolomisiewicz, Edward;Phillips, Christopher R.;Dawson, Timothy;Jamison, David;Young, Ryan;Pasquina, Paul F.
• 通讯作者: Pasquina, Paul F.

Presurgical sleep and pain behaviors predict insomnia symptoms and pain after total knee arthroplasty: a 12-month longitudinal, observational study.

术前睡眠和疼痛行为可预测全膝关节置换术后的失眠症状和疼痛：一项为期 12 个月的纵向观察性研究。

• DOI: 10.1093/pm/pnad106
• 发表时间: 2023
• 期刊: Pain medicine (Malden, Mass.)
• 作者: Owens,MichaelA;Mun,ChungJung;Hamilton,KatrinaR;Hughes,Abbey;Campbell,ClaudiaM;Edwards,RobertR;Smith,MichaelT
• 通讯作者: Smith,MichaelT

Chronic pain and infection: mechanisms, causes, conditions, treatments, and controversies.

• DOI: 10.1136/bmjmed-2021-000108
• 发表时间: 2022
• 期刊: BMJ medicine
• 作者: Cohen, Steven P.;Wang, Eric J.;Doshi, Tina L.;Vase, Lene;Cawcutt, Kelly A.;Tontisirin, Nuj
• 通讯作者: Tontisirin, Nuj

Nonorganic (Behavioral) Signs and Their Association With Epidural Corticosteroid Injection Treatment Outcomes and Psychiatric Comorbidity in Cervical Radiculopathy: A Multicenter Study.

非器质性（行为）体征及其与硬膜外皮质类固醇注射治疗结果和颈椎神经根病精神合并症的关联：一项多中心研究。

• DOI: 10.1016/j.mayocp.2022.11.022
• 发表时间: 2023
• 期刊: Mayo Clinic proceedings
• 影响因子: 8.9
• 作者: Cohen,StevenP;Doshi,TinaL;Dolomisiewicz,Edward;Reece,DavidE;Zhao,Zirong;Anderson-White,Mirinda;Kasuke,Angelia;Wang,EricJ;Hsu,Annie;Davis,SheltonA;Yoo,Yongjae;Pasquina,PaulF;Moon,JeeYoun
• 通讯作者: Moon,JeeYoun