BLR&D Research Career Scientist Application

BLR

• 批准号: 10293568
• 负责人: KALIPADA PAHAN
• 金额: --
• 依托单位: JESSE BROWN VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10293568
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s disease pathology; Animal Model; Apoptosis; Aspirin; Astrocytes; Attenuated; Autoimmune; Binding; Biogenesis; Brain; Brain region; CNS Demyelinating Autoimmune Diseases; CNS autoimmune disease; Cell Death; Cells; Cellular Metabolic Process; Cessation of life; Chemicals; Cholesterol; Clinical Trials; Dementia; Demyelinations; Disease; Exhibits; Exposure to; Fatty acid glycerol esters; Gender; Gliosis; Health; Hippocampus (Brain); Human; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Inflammation; Integrins; Interferon Type II; Interleukin-12; Knowledge; Lead; Lesion; Ligands; Link; Lovastatin; Magnetic Resonance Imaging; Mediating; Memory; Microglia; Multiple Sclerosis; Mus; Myelin; Nature; Nerve Degeneration; Neuraxis; Neurodegenerative Disorders; Neuroglia; Neurology; Neurons; Neurotoxins; Nitric Oxide; Oligodendroglia; PPAR alpha; Parkinson Disease; Pathway interactions; Pharmaceutical Preparations; Poison; Process; Production; Proteolysis; Recovery of Function; Regulation; Regulatory T-Lymphocyte; Research; Risk; Safety; Scientist; Services; Signal Pathway; Signal Transduction; T-Lymphocyte; TLR2 gene; Therapeutic; Therapeutic Agents; Time; Veterans; War; agent orange; brain cell; career; combat; improved; monomer; nerve stem cell; neuroinflammation; neuron apoptosis; neuron loss; neuroprotection; neurotoxic; neurotrophic factor; prostate cancer cell

Neurodegenerative disorders [e.g. Alzheimer's disease (AD) and Parkinson's disease (PD)] are a group of devastating conditions that are caused by progressive death of neurons in different regions of the brain. On the other hand, multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system, resulting in oligodendrocytes death and demyelination. Our lab primarily focuses on central nervous system (CNS) cell signaling that leads to neuronal death in Parkinson's disease (PD) and Alzheimer's disease (AD) and demyelination in multiple sclerosis (MS). All these disorders are characterized by activation of CNS glial cells (astroglia and microglia), excessive production of different proinflammatory molecules within the CNS, and death of either oligodendroglia (MS) or neurons (AD and PD). From several angles, we have been investigating mechanisms by which glial cells are activated to release different proinflammatory molecules and neurotoxins for inducing apoptosis and cell death in neurons and oligodendroglia. We are also involved in identifying signaling pathways by which glial cells may be redirected to produce neuroprotective molecules and neural stem cells could be driven towards neurons and myelin-producing cells (oligodendrocytes) within the neurodegenerative CNS. Finally, we are trying to suppress neurotoxic signaling pathways and/or boost neuroprotective signaling pathways in different animal models of neurodegenerative diseases by nontoxic drugs in order to achieve neuroprotection. Since many veterans are suffering from dementia, AD, PD, and MS, results from these studies will directly help veterans. 1

神经退行性疾病[如阿尔茨海默病（AD）和帕金森病（PD）]是一组神经系统疾病