Infection and Rapid Transmission of SARS-C0V-2 in Ferrets

雪貂中 SARS-C0V-2 的感染和快速传播

• 批准号: 10311369
• 负责人: Jae U Jung
• 金额: $ 51.97万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10311369
• 关键词: 2019-nCoV; 4 year old; ACE2; Age; Animal Model; Basic Science; Biochemical; Body Temperature; COVID-19; COVID-19 patient; COVID-19 susceptibility; COVID-19 vaccine; Characteristics; Clinical; Coughing; Disease Outbreaks; Epithelial Cells; Exhibits; Feces; Ferrets; Ferritin; Genes; Genetic; Genotype; Goals; Human; Immune Evasion; Immunity; In Vitro; Infection; Intervention; Length; Lung; Modeling; Mus; Nanotechnology; Nonstructural Protein; Nose; Pathogenesis; Pathogenicity; Permeability; Pharmacologic Substance; Recombinants; Reproducibility; Role; Route; SARS-CoV-2 infection; SARS-CoV-2 spike protein; SARS-CoV-2 transmission; Safety; Saliva; Sampling; Serum; Severe Acute Respiratory Syndrome; Severe Fever with Thrombocytopenia Syndrome Virus; Severity of illness; Specimen; Structure; Subunit Vaccines; Surface; Symptoms; Testing; Thrombocytopenia; Time; Transgenic Organisms; Urine; Vaccine Design; Vaccines; Viral; Virus; Virus Diseases; Virus Shedding; acute bronchiolitis; aged; animal model development; chronic infection; global health emergency; immunogenicity; in vivo; mRNA Differential Displays; mortality; nanoparticle; older patient; pandemic disease; parent grant; prevent; receptor binding; therapeutic development; transmission process; vaccine candidate; viral RNA; viral transmission; young adult

Project Summary/Abstract The massive outbreak of newly emerged coronavirus disease 2019 (COVID-19) has been rapidly spread worldwide, leading to a pandemic infection and serious global health emergency. In order to prevent further dissemination of severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), understanding the in vivo characteristics of viral infection and transmission is of high priority. Specifically, an animal model that recapitulates the COVID-19 clinical symptoms in human infection is urgently needed in order to decipher the transmission routes and pathobiology of this virus and ultimately allow testing of pharmaceutical interventions. With our expertise in the development of animal model, we have recently established a ferret model for SARS-CoV-2 infection and transmission that highly recapitulates aspects of the human infection. The main goal of this study is to comprehensively characterize ferret animal model for SARS-CoV-2 infection, transmission and pathogenesis for vaccine interventions.

项目概要/摘要 2019 年新型冠状病毒病（COVID-19）的大规模爆发已 病毒在全球范围内迅速传播，导致大流行性感染和严重的全球卫生紧急情况。在 为了防止严重急性呼吸系统综合症冠状病毒2（SARS- CoV-2），了解病毒感染和传播的体内特征是当务之急。 具体来说，是一种重现人类感染 COVID-19 临床症状的动物模型 迫切需要破译这种病毒的传播途径和病理学， 最终允许测试药物干预措施。凭借我们在开发方面的专业知识 动物模型，我们最近建立了 SARS-CoV-2 感染的雪貂模型， 高度概括了人类感染的各个方面的传播。这项研究的主要目标是 全面表征 SARS-CoV-2 感染、传播和传播的雪貂动物模型 疫苗干预的发病机制。