Microbiome-Balancing Wraps for Managing Eczema

用于治疗湿疹的微生物组平衡裹敷

• 批准号: 10324997
• 负责人: Hanumantharao Paritala
• 金额: $ 25.3万
• 依托单位: CFD RESEARCH CORPORATION
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10324997
• 关键词: Academy; Adverse effects; Advisory Committees; Affect; Alternative Therapies; American; Amides; Anabolism; Antibiotics; Area; Arthrodermataceae; Atopic Dermatitis; Atrophic; Bandage; Biological Assay; Branched-Chain Amino Acids; Cell Wall; Cells; Coin; Colony-forming units; Complementary therapies; Dermal; Dermatology; Dose; Early treatment; Eczema; Equilibrium; Esters; Fibroblasts; Flare; Goals; Gossypium; Growth; Hot Springs; Hydrolysis; In Vitro; Infection; Kinetics; Link; Maximum Tolerated Dose; Measures; Methods; Modeling; Monograph; Mucous Membrane; Mus; Natural Products; Organism; Pathogenicity; Patients; Pharmaceutical Chemistry; Pharmaceutical Preparations; Phase; Play; Positioning Attribute; Prevalence; Prevention; Problem Solving; Pruritus; Publishing; Reading; Regimen; Reporting; Research; Role; Rosacea; Roseomonas; Sampling; Silicones; Skin; Specificity; Staphylococcus aureus; Staphylococcus epidermidis; Steroids; Structure-Activity Relationship; Substance Withdrawal Syndrome; Symptoms; Technology; Testing; Textiles; Toxic effect; Trichophyton; Water; Western World; addiction; aminoacid biosynthesis; analog; antimicrobial; base; beneficial microorganism; covalent bond; cytotoxicity; dysbiosis; in vivo; indexing; intraperitoneal; microbiome; microorganism; natural antimicrobial; novel; pathogen; prevent; programs; prototype; side effect; skin microbiome; steroid dependence

Project Summary/Abstract: The long-term goal of this project is to develop microbiome-balancing antimicrobial wraps to use in the treatment of atopic dermatitis or eczema infections. The topical steroids used in the treatment of atopic dermatitis cause many side-effects and addiction. Additionally, the antibiotics used to treat AD infections eliminate skin commensals along with the targeted pathogens, resulting in skin microbial imbalance. Skin commensals play an important role in preventing the re-colonization and re- occurrence of the eczema by inhibiting the pathogens. Protective wraps or wet wraps made of skin commensal gentle antimicrobial compounds can prevent atopic dermatitis by promoting the growth of skin beneficial microbes and inhibiting the skin pathogens. CFD Research has discovered novel natural product-based compounds with skin commensal gentle targeted antimicrobial activity. In this proposal we seek to develop skin microbiome-gentle antimicrobial cotton fabrics that can release the compound at a certain rate to inhibit the pathogens while promoting growth of skin commensals.

项目概要/摘要： 该项目的长期目标是开发微生物平衡抗菌包裹物， 特应性皮炎或湿疹感染的治疗。用于治疗的局部类固醇 特应性皮炎引起许多副作用和成瘾。此外，用于治疗AD的抗生素 感染消除皮肤病原体沿着靶向病原体，导致皮肤微生物 不平衡皮肤移植物在防止再定植和再感染方面发挥着重要作用。 通过抑制病原体来抑制湿疹的发生。皮肤制成的保护性包裹物或湿包裹物 温和的抗菌化合物可以通过促进 皮肤有益微生物和抑制皮肤病原体。CFD研究发现了新的 天然产物为基础的化合物，具有温和的针对性抗菌活性。在这 建议我们寻求开发皮肤微生物群温和的抗菌棉织物，可以释放 按一定比例复配，在抑制病原菌的同时，促进皮肤细胞生长。