Noninvasive challenge-free widely-accessible oxygen extraction fraction mapping

这项拟议的研究的目标是开发一种非侵入性、无挑战和广泛可访问的 后处理脱氧血红素-铁法测定氧提取分数(OEF)的成像方法 多回波梯度回波(MGRE)数据。目前还没有临床上可用的工具来直接映射OEF 与脑氧代谢有关，高度提示脑血管和神经退行性变 精神错乱。我们建议包含经常被丢弃的包含磁场的mGRE相位信号 由脱氧血红素铁产生，用于通过QSM处理提高估计OEF的灵敏度。我们的 该项目将产生一个容易和广泛使用的定量OEF测绘工具，该工具可以常规使用 在所有广泛分布的核磁共振扫描仪上研究大脑功能和神经疾病。在这 在STTR1期项目中，我们将建立一种快速而可靠的OEF方法，供临床常规使用。我们会 通过两个具体目标来实现这一点。目的1.从mGRE数据中建立快速而稳健的OEF图。目标2. 在现有数据上验证开发的OEF映射，并参考150个PET OEF。

The objective of this proposed research is to develop a noninvasive, challenge-free and widely accessible, imaging method to map oxygen extraction fraction (OEF) determined by deoxyheme-iron from postprocessing multiecho gradient echo (mGRE) data. There is no clinically-available tool to map OEF that is directly associated with brain oxygen metabolism and highly indicative of cerebrovascular and neurodegenerative disorders. We propose to include the often-discarded mGRE phase signal, which contains the magnetic field generated by deoxyheme iron, for increased sensitivity in estimating OEF through QSM processing. Our project will result in an easily and widely usable tool for quantitative OEF mapping, which can be routinely used on all the extensively-distributed MRI scanners to study brain functions and neurological diseases. In this STTR phase 1 project, we will establish a rapid and robust OEF method for routine clinical use. We will achieve this through 2 specific aims. Aim 1. Develop a rapid and robust OEF mapping from mGRE data. Aim 2. Validate the developed OEF mapping on existing data with 15O PET OEF reference.