Diversity Supplement: Mechanisms underlying anabolic effects of cyclic compressive loading in muscle
Diversity Supplement: Mechanisms underlying anabolic effects of cyclic compressive loading in muscle
批准号:
10320577
负责人:
Timothy Alan Butterfield
金额:
$6.63万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-04-01 至 2023-03-31
关键词:
AcademiaAcquired Immunodeficiency SyndromeAddressAdministrative SupplementAdultAgingAnimalsAreaAtrophicAttenuatedBiochemical PathwayBiologyCellular biologyClinicalComplementary HealthComplementary therapiesComplexCongestive Heart FailureContralateralDataDevelopmentDevicesDiseaseElderlyEndocrineExerciseExtracellular MatrixFellowshipFocal Adhesion Kinase 1Focal AdhesionsFutureGoalsGrantGrowthHealthHealth SciencesHispanicsIntegrative MedicineInterventionInvestigationKnowledgeLaboratoriesLeadLimb structureMaintenanceMalignant NeoplasmsManipulative TherapiesMassageMechanical StimulationMechanicsMediatingMentorsModalityModelingMolecular BiologyMorbidity - disease rateMuscleMuscle WeaknessMuscular AtrophyNIH Program AnnouncementsNervous system structureNeuronsParentsPathway interactionsPatientsPeriodicityPlayPostdoctoral FellowProtein BiosynthesisProteinsQuality of lifeRattusRecoveryReproducibilityResearchResearch PersonnelRodentRoleScientific InquirySerumSkeletal MuscleStandardizationStudentsSymptomsTechniquesTestingTherapeutic InterventionTrainingTraining ProgramsUnderrepresented PopulationsWritingagedclinical paincytokinedesigndirect applicationdisabilitydiversity and equityexperienceexperimental studyfunctional declinegraduate studentinnovationintegrin-linked kinasemechanotransductionmembermortalitymuscle formnovelpain reliefpatient populationpre-doctoralpreventprogramsrelating to nervous systemresponserestorationrole modelskeletal muscle wastingskillsstudent mentoring
中文摘要
总结
本行政补充材料旨在为亚历山大Sklivas(亚历克斯)在以下实验室提供培训:
博士Dupont-Versteegden博士前研究员。这是对PA-21-017:研究补充,
促进健康相关研究的多样性。Alex将执行具体目标3中提出的实验
不仅能够在科学探究的技术应用方面获得经验,
但也将获得写作,演示和假设发展的熟练程度。他将进行实验
这将提供有关按摩的交叉效应的知识,我们已经观察到,在我们所有的
按摩模特他将研究大鼠血清中细胞因子水平的变化,
按摩此外,他将进行实验,以显示神经系统参与的水平,
按摩的交叉效应。他将接受初级导师的培训,
博士后、研究生。他将参加课程,如赠款写作和学术界,
除此之外,这为他未来的研究任务做好了准备,他将参加与内容相关的课程,如细胞
生物学和分子生物学培训计划的主要目标是准备亚历克斯成功的
申请F31博士前奖学金,这将为他提供获得博士学位所需的支持。
竞争性博士后奖学金。作为健康科学界代表性不足的群体的一员
(西班牙裔)他有能力成为其他学生或博士后研究员的好榜样,因为他是
已经参与了多样性,公平和包容性(DEI)领域的计划,他目前正在
承认。Dupont-Versteegden博士将担任Alex的导师,并积极参与学生辅导
以及DEI倡议。因此,这份补充将为亚历克斯提供科学背景,
并展示技能和学术知识,成为他所在领域的独立调查员。
选择
英文摘要
Summary
This administrative supplement is designed to provide training for Alexander Sklivas (Alex) in the laboratory of
Dr. Dupont-Versteegden as a predoctoral fellow. It is in response to PA-21-017: Research Supplement to
Promote Diversity in Health-Related Research. Alex will be performing experiments proposed in Specific Aim 3
of the parent RO1 and will be able to gain experience not only in the technical application of scientific inquiry,
but will also gain proficiency in writing, presenting and hypothesis development. He will perform experiments
that will provide knowledge about the cross over effect of massage that we have observed in all of our
massage models. He will investigate the changes in cytokine levels in serum from rats that have undergone
massage. In addition, he will perform experiments to show the level of involvement of the nervous system in
the cross over effect of massage. He will be trained in these techniques by the primary mentor as well as
postdoctoral fellow and senior graduate student. He will take classes, such as grant writing and academia and
beyond, that prepare him for future tasks as a researcher and he will take content related classes, such as cell
biology and molecular biology. The main goal of the training program is to prepare Alex for a successful
application of a F31 predoctoral fellowship which would provide him with the support needed to gain a
competitive postdoctoral fellowship. As a member of an underrepresented group in the health sciences
(Hispanic) he has the capability to be a good role model for other students or postdoctoral fellows, as he is
already involved in the area of diversity, equity and inclusion (DEI) in the program in which he currently is
admitted. Dr. Dupont-Versteegden will serve as a mentor for Alex and is heavily involved in student mentoring
as well as in DEI initiatives. Therefore, this supplement will provide Alex the scientific background, the writing
and presenting skills and the academic knowledge to become an independent investigator in the field of his
choice.
期刊论文(14)
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Mechanotherapy does not Enhance Recovery Following Muscle Disuse Atrophy in Female Rats.
机械疗法不能促进雌性大鼠肌肉废用性萎缩后的恢复。
DOI:
--
发表时间:
2022
期刊:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子:
--
作者:
[Sklivas,AlexanderB, Rose,Sarah, Abbott,Claire, Miller,Benjamin, Butterfield,Tim, Dupont-Versteegden,Esther]
通讯作者:
Dupont-Versteegden,Esther
Age-Related Susceptibility to Muscle Damage Following Mechanotherapy in Rats Recovering From Disuse Atrophy.
从废用性萎缩中恢复的大鼠在机械疗法后对肌肉损伤的年龄相关易感性。
DOI:
10.1093/gerona/glab186
发表时间:
2021
期刊:
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子:
--
作者:
[Hettinger,ZacharyR, Hamagata,Kyoko, Confides,AmyL, Lawrence,MarcusM, Miller,BenjaminF, Butterfield,TimothyA, Dupont-Versteegden,EstherE]
通讯作者:
Dupont-Versteegden,EstherE
Macrophage Regulation of Muscle Regrowth From Disuse in Aging.
巨噬细胞对衰老废用肌肉再生的调节。
DOI:
10.1249/jes.0000000000000201
发表时间:
2019
期刊:
Exercise and sport sciences reviews
影响因子:
5.7
作者:
[Reidy,PaulT, Dupont-Versteegden,EstherE, Drummond,MicahJ]
通讯作者:
Drummond,MicahJ
DOI:
10.1002/jcsm.12636
发表时间:
2021-03
期刊:
Journal of cachexia, sarcopenia and muscle
影响因子:
--
作者:
[Figueiredo VC, D'Souza RF, Van Pelt DW, Lawrence MM, Zeng N, Markworth JF, Poppitt SD, Miller BF, Mitchell CJ, McCarthy JJ, Dupont-Versteegden EE, Cameron-Smith D]
通讯作者:
Cameron-Smith D
DOI:
10.1249/jes.0000000000000244
发表时间:
2021-04-01
期刊:
Exercise and sport sciences reviews
影响因子:
5.7
作者:
[Van Pelt DW, Lawrence MM, Miller BF, Butterfield TA, Dupont-Versteegden EE]
通讯作者:
Dupont-Versteegden EE
共 10 条
Mechanisms underlying local and systemic effects of massage
-
批准号:10055850
-
项目类别:
-
资助金额:$24.28万
-
财政年份:2020
-
负责人:Timothy Alan Butterfield
-
依托单位:
Mechanisms underlying local and systemic effects of massage
-
批准号:10227221
-
项目类别:
-
资助金额:$19.74万
-
财政年份:2020
-
负责人:Timothy Alan Butterfield
-
依托单位:
Mechanisms underlying anabolic effects of cyclic compressive loading in muscle
-
批准号:9900758
-
项目类别:
-
资助金额:$42.33万
-
财政年份:2017
-
负责人:Timothy Alan Butterfield
-
依托单位:
Cyclic compressive loading to negate atrophy and impaired regrowth in aged muscle
-
批准号:8510878
-
项目类别:
-
资助金额:$22.48万
-
财政年份:2013
-
负责人:Timothy Alan Butterfield
-
依托单位:
Cyclic compressive loading as an intervention for skeletal muscle atrophy and imp
-
批准号:8666702
-
项目类别:
-
资助金额:$18.75万
-
财政年份:2013
-
负责人:Timothy Alan Butterfield
-
依托单位:
海外基金