Diversity Supplement: Mechanisms underlying anabolic effects of cyclic compressive loading in muscle

多样性补充：肌肉循环压缩负荷合成代谢效应的机制

基本信息

批准号：
10320577
负责人：
Timothy Alan Butterfield
金额：
$ 6.63万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10320577
关键词：
Academia Acquired Immunodeficiency Syndrome Address Administrative Supplement Adult Aging Animals Area Atrophic Attenuated Biochemical Pathway Biology Cellular biology Clinical Complementary Health Complementary therapies Complex Congestive Heart Failure Contralateral Data Development Devices Disease Elderly Endocrine Exercise Extracellular Matrix Fellowship Focal Adhesion Kinase 1 Focal Adhesions Future Goals Grant Growth Health Health Sciences Hispanics Integrative Medicine Intervention Investigation Knowledge Laboratories Lead Limb structure Maintenance Malignant Neoplasms Manipulative Therapies Massage Mechanical Stimulation Mechanics Mediating Mentors Modality Modeling Molecular Biology Morbidity - disease rate Muscle Muscle Weakness Muscular Atrophy NIH Program Announcements Nervous system structure Neurons Parents Pathway interactions Patients Periodicity Play Postdoctoral Fellow Protein Biosynthesis Proteins Quality of life Rattus Recovery Reproducibility Research Research Personnel Rodent Role Scientific Inquiry Serum Skeletal Muscle Standardization Students Symptoms Techniques Testing Therapeutic Intervention Training Training Programs Underrepresented Populations Writing aged clinical pain cytokine design direct application disability diversity and equity experience experimental study functional decline graduate student innovation integrin-linked kinase mechanotransduction member mortality muscle form novel pain relief patient population pre-doctoral prevent programs relating to nervous system response restoration role model skeletal muscle wasting skills student mentoring

项目摘要

Summary This administrative supplement is designed to provide training for Alexander Sklivas (Alex) in the laboratory of Dr. Dupont-Versteegden as a predoctoral fellow. It is in response to PA-21-017: Research Supplement to Promote Diversity in Health-Related Research. Alex will be performing experiments proposed in Specific Aim 3 of the parent RO1 and will be able to gain experience not only in the technical application of scientific inquiry, but will also gain proficiency in writing, presenting and hypothesis development. He will perform experiments that will provide knowledge about the cross over effect of massage that we have observed in all of our massage models. He will investigate the changes in cytokine levels in serum from rats that have undergone massage. In addition, he will perform experiments to show the level of involvement of the nervous system in the cross over effect of massage. He will be trained in these techniques by the primary mentor as well as postdoctoral fellow and senior graduate student. He will take classes, such as grant writing and academia and beyond, that prepare him for future tasks as a researcher and he will take content related classes, such as cell biology and molecular biology. The main goal of the training program is to prepare Alex for a successful application of a F31 predoctoral fellowship which would provide him with the support needed to gain a competitive postdoctoral fellowship. As a member of an underrepresented group in the health sciences (Hispanic) he has the capability to be a good role model for other students or postdoctoral fellows, as he is already involved in the area of diversity, equity and inclusion (DEI) in the program in which he currently is admitted. Dr. Dupont-Versteegden will serve as a mentor for Alex and is heavily involved in student mentoring as well as in DEI initiatives. Therefore, this supplement will provide Alex the scientific background, the writing and presenting skills and the academic knowledge to become an independent investigator in the field of his choice.

概括这种行政补充旨在为亚历山大·斯克里瓦斯（Alex）提供培训杜邦·维尔斯蒂格登（Dupont-Versteegden）博士是一名冠军前研究员。这是对PA-21-017的回应：研究补充促进与健康相关的研究的多样性。亚历克斯将执行特定目标3中提出的实验父级RO1，不仅能够在科学询问的技术应用方面获得经验但也将熟练地写作，表现和假设发展。他将执行实验这将提供有关我们在所有人中观察到的按摩的交叉效果的知识按摩模型。他将调查经历过大鼠血清中细胞因子水平的变化按摩。此外，他将进行实验以显示神经系统参与程度按摩的交叉效果。他将受到主要导师的培训以及博士后研究生和高级毕业生。他将上课，例如赠款写作和学术界以及除了，他为作为研究人员的未来任务做好了准备，他将参加与内容相关的班级，例如Cell 生物学和分子生物学。培训计划的主要目标是为成功准备亚历克斯 F31的应用前奖学金奖学金，这将为他提供获得所需的支持竞争性博士后奖学金。作为健康科学人数不足小组的成员（西班牙裔）他有能力成为其他学生或博士后研究员的好榜样，因为他是已经参与了他当前的计划中的多样性，公平和包容（DEI）领域承认。杜邦·维尔斯蒂格登（Dupont-Versteegden）博士将担任亚历克斯（Alex）的导师，并大量参与学生指导以及在DEI计划中。因此，这种补充剂将为亚历克斯提供科学背景，写作并提出技能和学术知识，成为他的领域的独立调查员选择。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Mechanotherapy does not Enhance Recovery Following Muscle Disuse Atrophy in Female Rats.

机械疗法不能促进雌性大鼠肌肉废用性萎缩后的恢复。

DOI：
发表时间：
2022
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
0
作者：
Sklivas,AlexanderB;Rose,Sarah;Abbott,Claire;Miller,Benjamin;Butterfield,Tim;Dupont-Versteegden,Esther
通讯作者：
Dupont-Versteegden,Esther

从废用性萎缩中恢复的大鼠在机械疗法后对肌肉损伤的年龄相关易感性。

DOI：
10.1093/gerona/glab186
发表时间：
2021
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
0
作者：
Hettinger,ZacharyR;Hamagata,Kyoko;Confides,AmyL;Lawrence,MarcusM;Miller,BenjaminF;Butterfield,TimothyA;Dupont-Versteegden,EstherE
通讯作者：
Dupont-Versteegden,EstherE

Ribosome biogenesis and degradation regulate translational capacity during muscle disuse and reloading.

DOI：
10.1002/jcsm.12636
发表时间：
2021-03
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
0
作者：
Figueiredo VC;D'Souza RF;Van Pelt DW;Lawrence MM;Zeng N;Markworth JF;Poppitt SD;Miller BF;Mitchell CJ;McCarthy JJ;Dupont-Versteegden EE;Cameron-Smith D
通讯作者：
Cameron-Smith D

Macrophage Regulation of Muscle Regrowth From Disuse in Aging.

巨噬细胞对衰老废用肌肉再生的调节。