New Catalysts, Strategies and Methods for Stereoselective Chemical Synthesis

立体选择性化学合成的新催化剂、策略和方法

• 批准号: 10322372
• 负责人: AMIR H HOVEYDA
• 金额: $ 57.91万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10322372
• 关键词: Address; Energy Metabolism; Generations; Goals; Medicine; Metals; Methods; Play; Preparation; Role; catalyst; chemical synthesis; cost; cost effective; design; drug development; programs; wasting

Project Summary: Stereochemically defined organic molecules play a crucial role in drug development and advances in medicine. Catalytic, efficient, selective, broadly applicable, practical (scalable) methods that provide access to such entities, and that are sustainable and cost effective (e.g., no precious metals) are much needed and in great demand. Despite notable recent advances, existing methods for the preparation of important bioactive compounds often do not satisfy many of the above criteria. The principal goal of this program is to design catalysts, and develop methods that address the above issues.

项目总结： 立体化学定义的有机分子在药物开发和开发中发挥着至关重要的作用 医学上的进步。催化、高效、选择性、广泛适用、实用(可扩展) 提供对这类实体的访问并具有可持续性和成本效益的方法(例如，没有 贵金属)非常需要，而且需求量很大。尽管最近取得了显著的进展，但现有的 制备重要生物活性化合物的方法往往不能满足许多人的要求 以上标准。这个项目的主要目标是设计催化剂，并开发出 解决上述问题。