Understanding the link between sleep deprivation and oxidative stress

了解睡眠不足和氧化应激之间的联系

• 批准号: 10445336
• 负责人: Dragana Rogulja
• 金额: $ 47.25万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-09 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445336
• 关键词: Animal Model; Animals; Antioxidants; Behavior; Biological Phenomena; Cause of Death; Cell Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chronic; Cognitive; Data; Delayed Sleep Phase Syndrome; Disease; Drosophila genus; Economic Burden; Epidemic; Free Radicals; Gardenal; General Population; Goals; Health; Homologous Gene; Human; Immune response; Impairment; Intestines; Knowledge; Large Intestine; Lead; Life; Life Style; Light; Link; Longevity; Malignant Neoplasms; Mammals; Mental disorders; Molecular; Mus; Narcolepsy; Organ; Oxidative Stress; Oxides; Oxygen; Pathway interactions; Persons; Process; Production; Property; Public Health; Reactive Oxygen Species; Role; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Disorders; Sleeplessness; Small Intestines; Societies; Source; Specificity; Testing; Tissues; Work; casein kinase I; cell injury; cell type; design; experience; experimental study; fly; health economics; nutrient absorption; oxidation; oxidative damage; premature; prevent; tool

Project Summary We discovered that sleep deprivation causes accumulation of free radicals (reactive oxygen species, ROS) and oxidative stress in the gut of flies and mice. This is in large part responsible for the premature death seen when sleep is very low. Here we propose to study what occurs upstream and downstream of ROS accumulation. Specifically, we will ask how the lack of sleep leads to increase in ROS, and how ROS then causes organismal death. Together, this will bring us closer to fully understanding what sleep does for health and longevity. This is an important problem as so many of us are chronically sleep deprived, and sleep deprivation causes or exacerbates a whole slew of diseases.

项目摘要 我们发现，睡眠不足会导致自由基(活性氧)的积累 在果蝇和小鼠的肠道中，ROS)和氧化应激。这在很大程度上是有责任的 因为睡眠很少的时候会出现过早死亡。在这里，我们打算研究发生了什么 ROS积累的上游和下游。具体地说，我们会问睡眠不足如何 导致ROS的增加，以及ROS是如何导致生物死亡的。总而言之，这将带来 我们更接近于充分了解睡眠对健康和长寿的作用。这是一个重要的 问题是我们很多人长期睡眠不足，睡眠不足会导致或 会加重一系列疾病。