The Texas-Louisiana Alliance to Study Chronic Pancreatitis, Diabetes and Pancreatic Cancer

德克萨斯州-路易斯安那州慢性胰腺炎、糖尿病和胰腺癌研究联盟

• 批准号: 10445065
• 负责人: SURESH T. CHARI
• 金额: $ 26.32万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-05 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445065
• 关键词: Accident and Emergency department; African American population; Algorithms; Ancillary Study; Biological; Cancer Center; Clinic; Clinical; Clinical Data; Clinical Research; Clinics and Hospitals; Cohort Studies; Collaborations; Communities; Computerized Medical Record; Consent; Diabetes Mellitus; Diagnosis; Diagnostic; Endocrinologist; Epidemiology; Evaluation; Exocrine pancreatic insufficiency; Familiarity; Felis catus; Functional disorder; Gastroenterologist; Gastroenterology; Goals; Health Sciences; Health system; Healthcare; Healthcare Systems; Hospitals; Hyperglycemia; Incidence; Information Technology; Infrastructure; Inpatients; Institution; Internist; Link; Location; Longitudinal cohort study; Louisiana; Malignant neoplasm of pancreas; Minority Groups; National Institute of Diabetes and Digestive and Kidney Diseases; Outpatients; Pancreatic Ductal Adenocarcinoma; Pathogenesis; Pathology; Patient Care; Patient Recruitments; Patients; Performance; Play; Population; Population Heterogeneity; Positioning Attribute; Primary Care Physician; Primary Health Care; Principal Investigator; Procedures; Prospective Studies; Prospective cohort; Race; Records; Research Personnel; Research Subjects; Resources; Retrospective Studies; Role; Running; Secondary to; Seminal; Series; Site; System; Testing; Texas; Therapeutic; Underrepresented Minority; Universities; base; chronic pain; chronic pancreatitis; cohort; data management; data warehouse; design; epidemiology study; ethnic diversity; experience; falls; innovation; insight; inter-institutional; novel; patient population; prospective; recruit; research study; success; tertiary care; translational study; working group

PROJECT SUMMARY/ABSTRACT Our proposal is in keeping with the objectives of the RFA to continue the excellent ongoing studies of the consortium (CPDPC) to study the relationship between Chronic Pancreatitis (CP), Diabetes (DM) and Pancreatic Cancer (PDAC). The Principal Investigators of this proposal (Drs. Chari and Maitra, both currently based at UT MD Anderson Cancer Center, UTMDACC) have played key and substantial roles in the first cycle of the CPDPC. First, they have served as co-leaders of the DM-PDAC working group, which has been responsible for the design and conduct of the ongoing NOD study, which was inspired by a series of seminal observations made by Dr. Chari in the 2000s. Second, Dr. Maitra has served as Co-PI of the Data Management and Coordination Center (DMCC) of the CPDPC, which provides him with extensive familiarity with the inner workings of data management and oversight required for accrual to NOD and other prospective cohorts. Third, Dr. Chari was previously the site Co-PI of Mayo Clinic site, which has contributed to all aspects of CPDPC in the last cycle. From the experience of the past 4.5 years, it is clear that successful recruitment of subjects to these studies requires a mix of tertiary care hospitals (for PROCEED and DETECT cohorts), combined with access to large primary care healthcare systems with integrated electronic medical record systems, information technology (IT) support and infrastructure (for the NOD study). To this end, an Alliance of Texas and Louisiana investigators and institutions overseen by the PIs at UTMDACC will recruit to ongoing CPDPC cohort studies. In addition, we propose 6 ancillary studies that are ideally suited for performance by a collaborative consortium and significantly advance our understanding of the interconnected pathologies of CP, PDAC and DM. In accordance with the RFA, the Specific Aims of our proposal are to: Aim 1 a) Recruit subjects for PROCEED study: This will occur at the University of Texas Health Sciences Center, Houston (UTHSC-H) and Memorial Hermann Health System, both large volume gastroenterology practices that are well positioned to recruit patients for the PROCEED Study. b) Recruit subjects for the DETECT study: The UTHSC-H will recruit patients for DETECT study c) Recruit subjects for the NOD Study: The recruitment will occur through the Ochsner Clinic, Louisiana, a large, integrated primary health system in Louisiana, which is also highly enriched for underrepresented minority population of African Americans, who are known to harbor a preponderance of both DM and PDAC. Aim 2) Perform a series of innovative ancillary studies to examine the association among CP, DM and PDAC: 6 such studies are outlined in this proposal.

项目摘要/摘要 我们的建议与RFA的目标是一致的，即继续对 研究慢性胰腺炎(CP)、糖尿病(DM)和胰腺疾病的关系 癌症(PDAC)。该提案的首席研究员(Chari博士和Maitra博士，两人目前都在德克萨斯大学工作 安德森癌症中心(UTMDACC)在CPDPC的第一个周期中发挥了关键和重要的作用。 首先，他们担任DM-PDAC工作组的联合领导人，该工作组一直负责设计 并进行正在进行的NOD研究，该研究的灵感来自于Dr。 查里在本世纪头十年。其次，Maitra博士曾担任数据管理和协调中心的联席PI (DMCC)，这使他对数据的内部工作原理有了广泛的了解 对NOD和其他预期队列的应计所需的管理和监督。第三，查里博士 以前是梅奥诊所网站的联合PI，在上一个周期中为社区发展方案的所有方面做出了贡献。 从过去4.5年的经验来看，很明显，成功招募这些研究的对象 需要混合使用三级护理医院(用于进行和检测队列)，并可访问大型 具有集成电子病历系统、信息技术(IT)的初级保健保健系统 支持和基础设施(用于NOD研究)。为此，德克萨斯州和路易斯安那州的调查人员和 由UTMDACC的PIs监督的机构将招募正在进行的CPDPC队列研究。此外，我们 建议6项辅助研究，这些研究非常适合由协作财团执行，并显著 促进我们对CP、PDAC和DM相互关联的病理机制的理解。根据《公约》 RFA，我们建议的具体目标是：目标1 a)招募受试者进行研究：这将发生在 德克萨斯大学休斯顿健康科学中心(UTHSC-H)和纪念赫尔曼健康系统， 这两个大容量的胃肠病学实践都处于很好的位置，可以为正在进行的研究招募患者。 B)招募检测研究的受试者：UTHSC-H将招募患者进行检测研究c)招募 NOD研究的对象：招募将通过路易斯安那州奥克斯纳诊所进行，该诊所是一家大型综合医院 路易斯安那州的初级卫生体系，这也为代表不足的少数民族人口提供了高度丰富的 非洲裔美国人，众所周知，他们同时拥有DM和PDAC的优势。目标2)执行一系列 检查CP、DM和PDAC之间关系的创新辅助研究：6个这样的研究概述 在这份提案中。