The Texas-Louisiana Alliance to Study Chronic Pancreatitis, Diabetes and Pancreatic Cancer

德克萨斯州-路易斯安那州慢性胰腺炎、糖尿病和胰腺癌研究联盟

• 批准号: 10445065
• 负责人: SURESH T. CHARI
• 金额: $ 26.32万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-05 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445065
• 关键词: Accident and Emergency department; African American population; Algorithms; Ancillary Study; Biological; Cancer Center; Clinic; Clinical; Clinical Data; Clinical Research; Clinics and Hospitals; Cohort Studies; Collaborations; Communities; Computerized Medical Record; Consent; Diabetes Mellitus; Diagnosis; Diagnostic; Endocrinologist; Epidemiology; Evaluation; Exocrine pancreatic insufficiency; Familiarity; Felis catus; Functional disorder; Gastroenterologist; Gastroenterology; Goals; Health Sciences; Health system; Healthcare; Healthcare Systems; Hospitals; Hyperglycemia; Incidence; Information Technology; Infrastructure; Inpatients; Institution; Internist; Link; Location; Longitudinal cohort study; Louisiana; Malignant neoplasm of pancreas; Minority Groups; National Institute of Diabetes and Digestive and Kidney Diseases; Outpatients; Pancreatic Ductal Adenocarcinoma; Pathogenesis; Pathology; Patient Care; Patient Recruitments; Patients; Performance; Play; Population; Population Heterogeneity; Positioning Attribute; Primary Care Physician; Primary Health Care; Principal Investigator; Procedures; Prospective Studies; Prospective cohort; Race; Records; Research Personnel; Research Subjects; Resources; Retrospective Studies; Role; Running; Secondary to; Seminal; Series; Site; System; Testing; Texas; Therapeutic; Underrepresented Minority; Universities; base; chronic pain; chronic pancreatitis; cohort; data management; data warehouse; design; epidemiology study; ethnic diversity; experience; falls; innovation; insight; inter-institutional; novel; patient population; prospective; recruit; research study; success; tertiary care; translational study; working group

PROJECT SUMMARY/ABSTRACT Our proposal is in keeping with the objectives of the RFA to continue the excellent ongoing studies of the consortium (CPDPC) to study the relationship between Chronic Pancreatitis (CP), Diabetes (DM) and Pancreatic Cancer (PDAC). The Principal Investigators of this proposal (Drs. Chari and Maitra, both currently based at UT MD Anderson Cancer Center, UTMDACC) have played key and substantial roles in the first cycle of the CPDPC. First, they have served as co-leaders of the DM-PDAC working group, which has been responsible for the design and conduct of the ongoing NOD study, which was inspired by a series of seminal observations made by Dr. Chari in the 2000s. Second, Dr. Maitra has served as Co-PI of the Data Management and Coordination Center (DMCC) of the CPDPC, which provides him with extensive familiarity with the inner workings of data management and oversight required for accrual to NOD and other prospective cohorts. Third, Dr. Chari was previously the site Co-PI of Mayo Clinic site, which has contributed to all aspects of CPDPC in the last cycle. From the experience of the past 4.5 years, it is clear that successful recruitment of subjects to these studies requires a mix of tertiary care hospitals (for PROCEED and DETECT cohorts), combined with access to large primary care healthcare systems with integrated electronic medical record systems, information technology (IT) support and infrastructure (for the NOD study). To this end, an Alliance of Texas and Louisiana investigators and institutions overseen by the PIs at UTMDACC will recruit to ongoing CPDPC cohort studies. In addition, we propose 6 ancillary studies that are ideally suited for performance by a collaborative consortium and significantly advance our understanding of the interconnected pathologies of CP, PDAC and DM. In accordance with the RFA, the Specific Aims of our proposal are to: Aim 1 a) Recruit subjects for PROCEED study: This will occur at the University of Texas Health Sciences Center, Houston (UTHSC-H) and Memorial Hermann Health System, both large volume gastroenterology practices that are well positioned to recruit patients for the PROCEED Study. b) Recruit subjects for the DETECT study: The UTHSC-H will recruit patients for DETECT study c) Recruit subjects for the NOD Study: The recruitment will occur through the Ochsner Clinic, Louisiana, a large, integrated primary health system in Louisiana, which is also highly enriched for underrepresented minority population of African Americans, who are known to harbor a preponderance of both DM and PDAC. Aim 2) Perform a series of innovative ancillary studies to examine the association among CP, DM and PDAC: 6 such studies are outlined in this proposal.

项目总结/摘要 我们的建议符合RFA的目标，即继续进行正在进行的关于 研究慢性胰腺炎（CP）、糖尿病（DM）与胰腺癌的关系。 癌症（PDAC）。该提案的主要研究者（Chari和Maitra博士，目前均在UT工作 MD安德森癌症中心，UTMDACC）在CPDPC的第一个周期中发挥了关键和实质性的作用。 首先，他们担任了负责设计的DM-PDAC工作组的共同领导人 和正在进行的NOD研究，这是由博士提出的一系列开创性的意见的启发。 2000年代的查里第二，Maitra博士曾担任数据管理和协调中心的联合PI CPDPC的DMCC，这使他非常熟悉数据的内部运作 NOD和其他前瞻性队列应计费用所需的管理和监督。第三，沙里博士是 之前是马约诊所临床试验机构的临床试验机构共同主要研究者，在上一个周期为CPDPC的各个方面做出了贡献。 从过去4.5年的经验来看，很明显，成功招募受试者参加这些研究 需要三级保健医院的混合（对于PROCEED和DETECT队列），结合获得大型 具有集成电子病历系统、信息技术（IT）的初级保健医疗系统 支持和基础设施（用于NOD研究）。为此，得克萨斯州和路易斯安那州的调查人员和 由UTMDACC PI监督的机构将招募正在进行的CPDPC队列研究。另外我们 提出6项辅助研究，这些研究非常适合合作联盟的表现， 促进我们对CP、PDAC和DM相互关联的病理学的理解。根据本 RFA，我们建议的具体目标是：目标1 a）招募PROCEED研究受试者：这将在 德克萨斯大学健康科学中心，休斯顿（UTHSC-H）和纪念赫尔曼卫生系统， 这两个大容量的胃肠病学实践都很适合招募PROCEED研究的患者。 B）招募DETECT研究的受试者：UTHSC-H将招募DETECT研究的患者 NOD研究的受试者：招募将通过路易斯安那州的Ochsner诊所进行，该诊所是一个大型的综合性诊所， 路易斯安那州的初级卫生系统，这也是高度丰富的代表性不足的少数民族人口 非裔美国人，谁是众所周知的港口都DM和PDAC的优势。（2）执行一系列 创新的辅助研究，以检查CP，DM和PDAC之间的关联：6个这样的研究概述 在这个提议中。