HeartShare DeCODE-HF: Data translation center to Combine Omics, Deep phenotyping, and Electronic health records for Heart Failure subtypes and treatment targets

HeartShare DeCODE-HF：数据翻译中心，结合组学、深度表型分析和电子健康记录，了解心力衰竭亚型和治疗目标

• 批准号: 10327457
• 负责人: ABEL N KHO
• 金额: $ 333.85万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-13 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10327457
• 关键词: Address; Ancillary Study; Area; Bioinformatics; Biological Specimen Banks; Biometry; Blood Vessels; Cardiac; Cardiovascular system; Clinical; Clinical Informatics; Clinical Research; Cohort Studies; Collaborations; Collection; Committee Members; Communication; Communities; Crystallization; Data; Data Aggregation; Data Coordinating Center; Data Science; Data Scientist; Data Set; Doctor of Philosophy; EFRAC; Electronic Health Record; Ensure; Epidemiology; Failure; Follow-Up Studies; Goals; Heart failure; Image; International; Investigation; Lead; Leadership; Machine Learning; Medicine; Molecular; Monitor; Morbidity - disease rate; Multicenter Studies; National Heart, Lung, and Blood Institute; Observational Study; Ontology; Operations Research; Outcome; Participant; Patient-Focused Outcomes; Patients; Phenotype; Prevalence; Protocols documentation; Research; Research Personnel; Research Priority; Resources; Sampling; Science; Site; Standardization; Surveys; Time; Trans-Omics for Precision Medicine; Translational Research; Translations; Universities; Validation; adjudicate; advanced analytics; base; biobank; catalyst; clinical center; cohort; computer human interaction; cost; data integration; data management; data portal; data quality; effective therapy; electronic consent; experience; health data; image archival system; mHealth; meetings; mortality; multiple omics; next generation; novel; novel strategies; outreach; phenomics; phenotypic data; precision medicine; preservation; programs; prospective; recruit; remote consent; skill acquisition; statistics; therapeutic target; tool; web based interface; working group

PROJECT SUMMARY The Overarching Aim of the Northwestern HeartShare DeCODE-HF: Data translation center to Combine Omics, Deep phenotyping, and Electronic health records for Heart Failure subtypes and treatment targets is to provide overall management and oversight for HeartShare, including coordination and communication across all subsections and cores of the program, and with the 4 HeartShare Clinical Centers (CCs). The Data Translation Center (DTC) will need to ensure timely completion of the retrospective and prospective components of HeartShare. In our application, we demonstrate the ability and prior experience of our multi-PI team and core leaders in the conduct and leadership of large-scale, multi-center studies, particularly in the realms of heart failure with preserved ejection fraction (HFpEF), electronic health record (EHR)-based investigation, deep phenotyping, machine learning, and biorepositories. For both the retrospective and prospective HeartShare components, the Northwestern DTC will leverage its considerable experience in: (1) cohorts and trials that have data on adjudicated HF patients, and (2) its leadership and track record as the top enroller in HFpEF trials/studies to ensure optimal recruitment by the HeartShare CCs. We will also leverage our expertise in HFpEF, data coordination/management, BioData Catalyst, EHR-based research, biostatistics, machine learning, multi-omics, human-computer interaction, and mobile health data monitoring to (1) successfully execute the HeartShare program and (2) meet the HeartShare DTC goals of providing a rich resource to the research community to advance the science of next-generation phenomics to identify HFpEF subtypes and therapeutic targets. Our HeartShare DTC will carry out each of its 4 primary responsibilities. (1) The Administrative and Outreach Core will oversee HeartShare program operations, research skills development, and capitation to CCs for deep phenotyping costs; support a call center to follow patient outcomes; and promote rapid and broad data-sharing of clinical and molecular data. (2) The Data Portal Core will serve as the primary access point (via a web-based interface) and coordinating center for all HeartShare data; and to develop an interactive patient-facing web-based interface for remote consent, completion of forms, and collection of mobile health data using BioData Catalyst tools. (3) The Data Management Core will oversee ensure data quality, integration and harmonization of various data types; perform advanced analytics; coordinate biospecimen and imaging biorepositories; and integrate with TOPMed for omics analyses. (4) The Cohort Core will aggregate data on HF patients from completed epidemiology cohorts and HF trials and will combine data with further bioprofiling of existing samples to allow discovery/validation of novel targets.

项目概要 Northwestern HeartShare DeCODE-HF 的总体目标：数据翻译中心到合并 心力衰竭亚型和治疗的组学、深度表型分析和电子健康记录 目标是为 HeartShare 提供全面管理和监督，包括协调和监督 跨该计划的所有子部分和核心以及与 4 个 HeartShare 临床中心的沟通 （CC）。数据翻译中心（DTC）需要确保及时完成追溯和 HeartShare 的前瞻性组成部分。在我们的申请中，我们展示了以下人员的能力和先前经验 我们的多 PI 团队和核心领导者在开展和领导大规模、多中心研究方面，特别是 在射血分数保留 (HFpEF) 心力衰竭领域，基于电子健康记录 (EHR) 调查、深度表型分析、机器学习和生物样本库。对于回顾和 未来的 HeartShare 组件，西北 DTC 将利用其在以下方面的丰富经验：(1) 拥有已判定心衰患者数据的队列和试验，以及 (2) 其领先地位和往绩记录 HFpEF 试验/研究的招募者，以确保 HeartShare CC 的最佳招募。我们还将利用我们的 HFpEF、数据协调/管理、BioData Catalyst、基于 EHR 的研究、生物统计学、 机器学习、多组学、人机交互和移动健康数据监测 (1) 成功执行 HeartShare 计划并 (2) 实现 HeartShare DTC 目标，即提供丰富的 为研究界提供资源，以推进下一代表型组学科学以确定 HFpEF 亚型和治疗靶点。我们的 HeartShare DTC 将履行其 4 项主要职责。 (1) 行政和外展核心将监督 HeartShare 计划的运营、研究技能 开发和按人头付费的 CC 进行深度表型分析成本；支持呼叫中心跟踪患者的治疗结果； 促进临床和分子数据快速、广泛的数据共享。 (2) 数据门户核心将作为 所有 HeartShare 数据的主要访问点（通过基于 Web 的界面）和协调中心；并到 开发一个面向患者的交互式网络界面，用于远程同意、填写表格和收集 使用 BioData Catalyst 工具收集移动健康数据。 (3) 数据管理核心将监督确保数据 各种数据类型的质量、集成和协调；执行高级分析；协调 生物样本和成像生物样本库；并与 TOPMed 集成进行组学分析。 (4) 队列核心 将汇总来自已完成的流行病学队列和心力衰竭试验的心力衰竭患者的数据，并将合并数据 对现有样品进行进一步的生物分析，以发现/验证新靶点。