Core 3: Translational Pathology Shared Resource Core

核心 3：转化病理学共享资源核心

• 批准号: 10328042
• 负责人: BEN H PARK
• 金额: $ 2.79万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10328042
• 关键词: Advocacy; African American; Anatomy; Antigens; Awareness; Basic Science; Bioinformatics Shared Resource; Biological Markers; Biometry; Biopsy Specimen; Blood; Cancer Center; Cells; Clinical Trials; Collaborations; Collection; Communities; Consultations; DNA; Development; Doctor of Philosophy; Fee-for-Service Plans; Fluorescence; Formalin; Foundations; Future; General Hospitals; Genomics; Goals; Histologic; Histology; Histopathology; Human; Immune; In Situ; Institution; Malignant Neoplasms; Medical Research; Messenger RNA; Minority Groups; Molecular Biology; Morphology; Normal tissue morphology; Operative Surgical Procedures; Paraffin Embedding; Pathology; Pilot Projects; Population; Population Research; Process; Proteomics; Research; Research Personnel; Research Project Grants; Resource Sharing; Role; Services; Slide; Stains; Techniques; Technology; Tennessee; Time; Tissue Banks; Tissue Sample; Tissues; Translational Research; Universities; Work; animal tissue; anticancer research; base; cancer health disparity; clinical diagnostics; design; human tissue; imaging capabilities; liquid biopsy; medical schools; microscopic imaging; molecular diagnostics; neoplastic; outreach; repository; tissue archive; tissue processing

PROJECT SUMMARY: TRANSLATIONAL PATHOLOGY SHARED RESOURCE CORE The Translational Pathology Shared Resource Core (TPSRC) provides collaborative and fee-for service support to enhance basic and translational research efforts for Meharry Medical College (MMC), Vanderbilt-Ingram Cancer Center (VICC), and Tennessee State University (TSU) investigators. The TPSRC integrates the Human Tissue Acquisition, Histology/Immunohistochemical/Histopathology, and Morphology Cores, centrally located at MMC to provide a comprehensive suite of continually expanding high-quality services including human cancer research tissue banking and distribution, human and animal tissue processing, sectioning, routine and special staining, immune-based cell antigen staining, mRNA and DNA in-situ localization, histological and histopathological review and interpretation, and a variety of state of the art imaging capabilities. The collection of well-characterized human tissue for correlative research and molecular biology studies is a critical part of cancer research and is the foundation for the development of effective translational medical research and personalized molecular diagnostics and treatment. The TPSRC works collaboratively with the research community and designs, implements, and validates new Core approaches and services. To facilitate integration with the Biostatistics and Bioinformatics Shared Resource Core, MMC provides an on-campus office for in-house consultation purposes for investigators who routinely utilize the TPSRC. Our collaboration with the Cancer Outreach Core in an advocacy and educational role enhances awareness of research efforts to eliminate cancer disparities in African American and minority groups. The TPSRC will work closely with the Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core for biospecimen collection. Further the TPSRC will actively engage with the MVTCP–sponsored research projects proposed by Josiah Ochieng, PhD, (Project 2) and Anil Shanker, PhD, (Pilot Project) to provide tissues and pathology services to support their research initiatives.

项目总结：翻译病理学共享资源核心 转化性病理学共享资源核心(TPSRC)提供协作和收费服务支持 加强范德比尔特-英格拉姆梅哈里医学院(MMC)的基础和翻译研究工作 癌症中心(VICC)和田纳西州立大学(TSU)的调查人员。TPSRC整合了人类 组织获取、组织学/免疫组织化学/组织病理学和形态学核心，集中在 MMC将提供包括人类癌症在内的一整套不断扩大的高质量服务 研究组织储藏和分配，人体和动物组织加工，切片，常规和特殊 染色、免疫细胞抗原染色、mRNA和DNA原位定位、组织学和 组织病理学检查和解释，以及各种最先进的成像能力。收藏品 用于相关研究和分子生物学研究的具有良好特性的人体组织是 癌症研究，是发展有效的转化医学研究和 个性化的分子诊断和治疗。TPSRC与这项研究合作 社区，并设计、实施和验证新的核心方法和服务。以促进整合 有了生物统计和生物信息学共享资源核心，MMC为内部提供了一个校园办公室 为经常使用TPSRC的调查人员提供咨询目的。我们与巨蟹的合作 宣传和教育作用的外展核心提高了对消除癌症的研究努力的认识 非裔美国人和少数群体之间的差距。TPSRC将与人口研究中心密切合作 和癌症临床试验公平(实践)共享资源核心的生物样品收集。再往前走 TPSRC将积极参与由MVTCP赞助的由Josiah Ochieng，PhD， (项目2)和Anil Shanker博士(试点项目)提供组织和病理服务，以支持他们的 研究计划。