Identifying Molecular Subtypes of Head and Neck Cancer in Patients with African Ancestry
鉴定非洲血统患者头颈癌的分子亚型
基本信息
- 批准号:10452965
- 负责人:
- 金额:$ 9.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-03 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:AfricanAnatomyBiologicalDNA Sequence AlterationDevelopmentFrequenciesGenetic TranscriptionGenomicsGoalsHead and Neck CancerHead and Neck Squamous Cell CarcinomaHealth Services AccessibilityHuman PapillomavirusIncidenceIndividualLarynxMalignant NeoplasmsMethodsMolecularMolecular ProfilingMutationOral cavityOropharyngealOutcomePathway AnalysisPathway interactionsPatient Self-ReportPatientsPopulationPopulation StudyPrecision therapeuticsProtocols documentationRaceResearchSample SizeSurvival RateTestingTrainingTreatment outcomeWorkbaseblack patientcancer carecancer typegenomic profileshealth care disparityhealth disparityimprovedinhibitor/antagonistmolecular subtypesnovelpatient populationpatient stratificationpersonalized medicineprofiles in patientssocial health determinantstargeted treatmenttherapeutic targettooltranscriptomicstumor
项目摘要
Project Summary
The goal of this diversity supplement is to provide a 2-year training pathway for Maryum Cheema to expand her
scientific training in head and neck cancer and health care disparity research. Head and neck squamous cell
carcinoma (HNSCC) is the 7th most common cancer worldwide and is observed in the oral cavity, oropharynx,
and larynx. With a 5-year survival rate of fifty percent, precision therapy advances are desperately needed for
HNSCC patients. Population-based studies have identified disparities between racial groups in HNSCC
treatment and survival, especially for patients with African ancestry. This disparity exists even after controlling
for social determinants of health and access to care. The younger incidence of HNSCC in black patients
compared to white patients suggests a biological component may be contributing. Genomic and transcriptomic
correlations for ancestry have been assessed across cancer and in individual cancer types. However, most of
these studies are limited in sample size for HNSCCs, define race based on self-reporting, and have not
considered HPV status or anatomical subtype. Because of this, a subset of targetable mutations or pathways
could be missing for non-caucasian populations. In the context of genomics research, more accurate tools such
as genomic methods must be used when defining and stratifying patients based on race.
Here, we will fill this gap in the field by characterizing the molecular features of HNSCC tumors specifically in
patients with African ancestry, as defined computationally (rather than by self-reporting). These analyses will
give us an unbiased estimate of the relation of ancestry/race and HNSCC molecular features. In addition to DNA
alterations, we will also identify transcriptomic changes associated with HNSCC. Pathway analysis of will
uncover tumor vulnerabilities in black patients which may be therapeutic targets.
Our preliminary analysis identified a higher frequency of MYC amplifications and increased MYC transcriptional
activity in HNSCC tumors of patients with African ancestry., In this proposal, we will also assess the utility of two
novel MYC inhibitors as a targeted therapy for HNSCC.
Taken together, our work will deepen the understanding of HNSCC in patients with African ancestry, with the
ultimate goal of developing personalized therapies and reducing health disparities.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Fatemeh Momen Heravi其他文献
Fatemeh Momen Heravi的其他文献
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{{ truncateString('Fatemeh Momen Heravi', 18)}}的其他基金
Role of long non-coding RNAs in exosome biogenesis
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- 批准号:
10713910 - 财政年份:2023
- 资助金额:
$ 9.92万 - 项目类别:
Immune and transcriptomic biomarkers of progressive oral premalignant lesions
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10770711 - 财政年份:2023
- 资助金额:
$ 9.92万 - 项目类别:
Identifying Molecular Subtypes of Head and Neck Cancer in Patients with African Ancestry
鉴定非洲血统患者头颈癌的分子亚型
- 批准号:
10286972 - 财政年份:2021
- 资助金额:
$ 9.92万 - 项目类别:
Identifying Molecular Subtypes of Head and Neck Cancer in Patients with African Ancestry
鉴定非洲血统患者头颈癌的分子亚型
- 批准号:
10624505 - 财政年份:2021
- 资助金额:
$ 9.92万 - 项目类别:
Identifying Molecular Subtypes of Head and Neck Cancer in Patients with African Ancestry
鉴定非洲血统患者头颈癌的分子亚型
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10445340 - 财政年份:2021
- 资助金额:
$ 9.92万 - 项目类别:
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