Center for Quantitative Biology: A focus on "omics", from organisms to single cells Project 2

定量生物学中心：关注“组学”，从有机体到单细胞项目 2

• 批准号: 10452129
• 负责人: Siming Zhao
• 金额: $ 43.49万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10452129
• 关键词: Biology; Cancer Etiology; Cells; Genetic Predisposition to Disease; Genome; Learning; Malignant Neoplasms; Methods; Mutation Analysis; Organism; Sampling; Statistical Methods; Untranslated RNA; driver mutation; genomic data; tumor progression

We will develop statistical methods for analyzing mutations that occur in noncoding regions of the genome and likely contribute to the initiation or progression of cancer. These methods will give us better power to identify driver mutations and mutations with regulatory effects. These methods will be applied on large genomic datasets collected from cancer samples and will allow us to learn more about the genetic etiology of cancer.

我们将开发统计方法来分析发生在基因组和非编码区突变