Enabling High-Impact Collaborative Clinical and Translational Research through Effective Information Management: A Prototype Intervention

通过有效的信息管理实现高影响力的协作临床和转化研究：原型干预

• 批准号: 10637143
• 负责人: Betsy Ann Rolland
• 金额: $ 38.25万
• 依托单位: SAGE BIONETWORKS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-04 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10637143
• 关键词: Address; Agreement; Authorship; Behavior; Biometry; Catalogs; Cellular biology; Clinical Research; Clinical and Translational Science Awards; Collaborations; Communication; Communities; Complement; Complex; Computer software; Data; Discipline; Discipline of Nursing; Electronic Mail; Electronics; Ensure; Epidemiology; Equity; Evaluation; Evidence based intervention; Fostering; Funding Agency; Future; Goals; Guidelines; Health; Human; Hybrids; Individual; Information Management; Information Sciences; Institution; Intervention; Investments; Knowledge; Learning Module; Maps; Measures; Methods; Oncology; Outcome; Outcomes Research; Participant; Persons; Population; Practice Management; Process; Public Health; Records; Reproducibility; Research; Research Personnel; Resources; Role; Science; Telephone; Testing; Text Messaging; Time; Training; Translating; Translation Process; Translational Research; United States National Library of Medicine; Wisconsin; Work; Work Simplification; bench to bedside; cancer care; care delivery; clinical implementation; community engagement; digital; evidence base; health equity; health management; improved; pilot test; product development; prototype; research and development; tool; translational impact; translational pipeline; usability

PROJECT SUMMARY An interdisciplinary, team science approach is required to address our most complex scientific questions. Yet team science can be challenging, as collaboration requires additional coordination and communication to succeed and few researchers are trained in strategies to support collaborative work. Previous research has identified practices and activities of effective collaborative science teams, including collaboration planning, authorship agreements, and clear roles and responsibilities. Central to these activities is effective, efficient management of information, defined here as the human-generated digital objects of the team's work to achieve its scientific goals. Translational Teams (TTs), those conducting Clinical and Translational Research (CTR), are an ideal population in which to investigate questions of team science and information management. TTs are a hybrid of academic research and product development teams, with a goal of creating and advancing a discovery from the bench to the clinic to the community. To accomplish this, TTs work across disciplines and institutions, potentially over long periods of time, engaging with a wide variety of information to generate new biomedical knowledge. Currently, we know little about the ways in which TTs engage with information across the translational spectrum. Previous research has shown that TTs use a constellation of information strategies, processes, and tools simultaneously and, often, haphazardly, to manage the information of CTR. This haphazard approach to information management leads to lost or misplaced information, inaccurate records, and delays in efforts to improve health. Poorly documented studies can jeopardize study participants when key information is not tracked and communicated. This gap in TTs' information management represents an opportunity to improve how TTs conduct research, increase rigor and reproducibility, and expedite implementation of CTR. The long-term goal of this research is to improve the capacity of TTs for doing high- impact team science by improving their ability to manage their projects' information. Our mixed methods project will complete the following aims. Aim 1: Develop a conceptual framework describing the impact of TT information behaviors on the conduct of CTR. We will identify and catalog the information involved in CTR and the strategies, tools and processes TTs use to engage with information, then develop a conceptual framework that maps the information behaviors that facilitate or impede the conduct of high-impact collaborative CTR. Aim 2: Prototype and test an educational module to train and coach TTs in developing and implementing team- and individual-level information management strategies adapted to the team's collaboration context. We will create and test a feasible, usable intervention to help TTs improve their information management practices. The expected outcome is an intervention to facilitate improved conduct of team-based CTR. Future work will include validating the intervention across the Clinical and Translational Science Award hubs and beyond, as well as measuring long-term impact on scientific outcomes.

项目摘要 需要跨学科的团队科学方法来解决我们最复杂的科学问题。然而 团队科学可能具有挑战性，因为协作需要额外的协调和沟通， 很少有研究人员接受过支持协作工作的战略方面的培训。先前的研究 确定有效的协作科学团队的做法和活动，包括协作规划， 作者协议，明确的角色和责任。这些活动的核心是有效、高效 信息管理，这里定义为人类生成的数字对象，是团队工作中实现的 其科学目标。翻译团队（TT），即进行临床和转化研究（CTR）的团队， 是研究团队科学和信息管理问题的理想人群。TTS 是一个学术研究和产品开发团队的混合体，其目标是创建和推进一个 从实验室到诊所再到社区。为了实现这一点，TT跨学科工作， 机构，可能在很长一段时间内，从事各种各样的信息，以产生新的 生物医学知识。目前，我们对TT处理跨平台信息的方式知之甚少。 平移光谱先前的研究表明，TT使用一系列信息策略， 过程和工具，同时，往往是偶然的，以管理CTR的信息。这 随意的信息管理方法会导致信息丢失或放错地方，记录不准确， 以及改善健康的努力的拖延。记录不良的研究可能会危及研究参与者， 信息不被跟踪和传递。TT信息管理中的这一差距代表了 有机会改善TT如何进行研究，提高严谨性和可重复性，并加快 实施CTR。这项研究的长期目标是提高TT的能力， 通过提高他们管理项目信息的能力来影响团队科学。我们的混合方法 项目将完成以下目标。目标1：制定一个概念框架，说明技术转让的影响 对CTR行为的信息行为。我们将对CTR中涉及的信息进行识别和分类， TT用于处理信息的策略、工具和流程，然后开发概念框架 它描绘了促进或阻碍高影响力协作CTR的信息行为。目的 2：原型和测试教育模块，以培训和指导TT开发和实施团队-以及 适应团队协作环境的个人级信息管理策略。我们将创建 并测试一种可行的、可用的干预措施，以帮助TT改进其信息管理实践。的 预期结果是采取干预措施，促进改进基于团队的CTR的实施。未来的工作将 包括在临床和转化科学奖中心及其他地方验证干预措施， 以及衡量对科学成果的长期影响。