Mechanistic and Bioinformatics Core

摘要-核心C 训练免疫的特征是表观基因组、基因表达、新陈代谢和 细胞动力学。与该项目相关的调查人员将对以下项目进行全面研究 在移植的背景下训练免疫力。保障培训项目的适当实施 通过不同项目的免疫分析，我们建立了一个机械学和生物信息学核心 (核心C)。CORE C将在西奈山运行，由国际专家乔迪·奥昌多博士指导 公认的移植免疫学家，器官移植中训练有素的免疫学的创始人之一 研究。核心团队将提供专业知识和内部优化的方案，以分析免疫细胞和 从生物学角度验证有前景的治疗靶点。重要的是，这个核心还将保护生物信息学和 生物统计分析以及一般数据管理和存储。最后，核心C将实现和管理 Labguru是一个实验室管理系统，用于跟踪样本、记录和共享协议和数据，以及 保持库存。

SUMMARY – CORE C Trained immunity is characterized by pronounced changes in the epigenome, gene expression, metabolism, and cell dynamics. The investigators associated with this Program Project will perform comprehensive studies on trained immunity in the context of transplantation. To safeguard the appropriate implementation of trained immunity assays across the different projects, we have established a Mechanistic and Bioinformatics Core (Core C). Core C will operate at Mount Sinai and be directed by Dr. Jordi Ochando, an internationally recognized transplant immunologist and one of the founders of trained immunity in organ transplantation research. The Core team will provide expertise and in-house optimized protocols to profile immune cells and biologically validate promising therapeutic targets. Importantly, this Core will also safeguard bioinformatics and biostatistics analyses and general data management and storage. Lastly, Core C will implement and manage Labguru, a laboratory management system used to track samples, record, and share protocols and data, and keep inventory.