Animal Model Research for Veterinarians (AMRV)

兽医动物模型研究 (AMRV)

• 批准号: 10641790
• 负责人: XIANG-JIN MENG
• 金额: $ 39.03万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641790
• 关键词: Animal Model; Research; Veterinarians

Project Summary Doctors of Veterinary Medicine (DVMs) are uniquely qualified to conduct biomedical research in the field of comparative medicine using animal models. Unfortunately, the majority of DVMs do not pursue research- related careers, partly due to the lack of research training opportunities. Consequently, there is a critical shortage of veterinarians with research backgrounds conducting biomedical research across the nation. This proposed “Animal Model Research for Veterinarians” (AMRV) program will train veterinarians to become world- class researchers and pursue a research-related career after training. By taking advantage of the research strengths of faculty mentors at Virginia Tech, the AMRV program will train veterinarians in areas including animal models of immunology and inflammation, infectious diseases, and neuroscience. We will recruit from all 30 accredited veterinary medical schools in the nation, particularly from Tuskegee University with the objective of recruiting underrepresented minorities. A total of six DVMs will be recruited into the Virginia Tech’s Biomedical and Veterinary Sciences (BMVS) PhD program over the entire 5-year funding period of the program. We will recruit one new trainee each year in years 1 and 3-5, and two new trainees in year 2. Mentors will be selected based on their commitment to student training, their cutting-edge research programs, and their ability to secure NIH and other major federal funding. In addition to the Virginia-Maryland College of Veterinary Medicine (VMCVM), opportunities for trainees to work at the Edward Via College of Osteopathic Medicine (VCOM) and the Fralin Biomedical Research Institute (FBRI) at Virginia Tech Carilion School of Medicine will increase opportunities for studying animal models of human diseases and conduct translational medicine research. Our trainees will also be exposed to cutting-edge interdisciplinary collaborations of our faculty with researchers at other colleges (Engineering, Sciences, and Agricultural and Life Sciences). A unique feature of this program will be a visit to NIH, USDA, FDA, and other federal agencies in the Washington, DC area so that AMRV trainees can understand the breadth of research-related career opportunities available to them. Also, each week in the summer, in our complementary training program (T35), we bring in DVM/PhD scientists from the federal government, medical schools, biotech and biopharma, which will give additional opportunities for our T32 trainees to network with these scientists. The training plan includes courses in research ethics, methodology, grant writing, and communications in science as well as opportunities to present research at local and national conferences. All aspects of the training are focused on preparing trainees to become independent biomedical researchers mostly in academia, but in industry and federal government as well. Thus, this T32 AMRV program will enable VMCVM to continue to help train the next generation of veterinary biomedical leaders in academia, federal government, and industry.

项目概要 兽医博士（DVM）拥有在以下领域进行生物医学研究的独特资格： 使用动物模型进行比较医学。不幸的是，大多数 DVM 并不从事研究—— 相关职业，部分原因是缺乏研究培训机会。因此，有一个关键的 全国范围内缺乏具有研究背景的从事生物医学研究的兽医。这 拟议的“兽医动物模型研究”（AMRV）计划将培训兽医成为世界级的兽医 课程研究人员并在培训后从事与研究相关的职业。通过利用研究 凭借弗吉尼亚理工大学教师导师的优势，AMRV 项目将在以下领域培训兽医： 免疫学和炎症、传染病和神经科学的动物模型。我们将向各界招募 全国 30 所经过认证的兽医医学院，特别是塔斯基吉大学的兽医学院，其目标是 招募代表性不足的少数群体。弗吉尼亚理工大学将招募总共六名 DVM 整个 5 年资助期内的生物医学和兽医科学 (BMVS) 博士课程 程序。我们将在第一年和第三年至第五年每年招募一名新学员，并在第二年招募两名新学员。 导师的选择将基于他们对学生培训的承诺、前沿研究项目、 以及他们获得 NIH 和其他主要联邦资金的能力。除了弗吉尼亚-马里兰学院 兽医学 (VMCVM)，为学员提供在爱德华维亚整骨学院工作的机会 弗吉尼亚理工大学卡里利恩学院医学 (VCOM) 和弗拉林生物医学研究所 (FBRI) 医学将增加研究人类疾病动物模型并进行转化的机会 医学研究。我们的学员还将接触到我们的尖端跨学科合作 教师与其他学院（工程学院、科学学院、农业与生命科学学院）的研究人员。一个 该项目的独特之处在于参观 NIH、USDA、FDA 和其他联邦机构 华盛顿特区，让 AMRV 学员能够了解研究相关职业的广度 他们可以获得的机会。此外，夏季的每周，在我们的补充培训计划 (T35) 中， 我们从联邦政府、医学院、生物技术和生物制药领域引进了 DVM/PhD 科学家， 将为我们的 T32 学员提供与这些科学家建立联系的更多机会。培训计划包括 研究伦理、方法论、资助写作、科学交流以及机会等课程 在地方和国家会议上展示研究成果。培训的各个方面都注重准备 受训者成为独立的生物医学研究人员，主要在学术界，但在工业界和联邦 政府也是如此。因此，这个 T32 AMRV 计划将使 VMCVM 能够继续帮助训练下一个 学术界、联邦政府和工业界的一代兽医生物医学领袖。

项目成果

Sex linked behavioral and hippocampal transcriptomic changes in mice with cell-type specific Egr1 loss.

• DOI: 10.3389/fnins.2023.1240209
• 发表时间: 2023
• 期刊: FRONTIERS IN NEUROSCIENCE
• 影响因子: 4.3
• 作者: Swilley, Cody;Lin, Yu;Zheng, Yuze;Xu, Xiguang;Liu, Min;Jarome, Timothy;Hodes, Georgia E.;Xie, Hehuang
• 通讯作者: Xie, Hehuang

Sex-Linked Growth Disorder and Aberrant Pituitary Gene Expression in Nestin-Cre-Mediated Egr1 Conditional Knockout Mice.

• DOI: 10.3390/biology12070966
• 发表时间: 2023-07-06
• 期刊: Biology
• 影响因子: 4.2