Neurodevelopment of executive function, appetite regulation, and obesity in children and adolescents

儿童和青少年执行功能、食欲调节和肥胖的神经发育

• 批准号: 10643633
• 负责人: Shana Adise
• 金额: $ 14.99万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10643633
• 关键词: 6 year old; Abdomen; Address; Adolescence; Adolescent; Adolescent obesity; Affect; Age; Appetite Regulation; Attenuated; Award; Behavioral; Biological Markers; Birth; Body Composition; Body fat; Bottle feeding; Brain; Brain region; Cattle; Child; Child Development; Child Health; Childhood; Complex; Data; Data Analyses; Data Set; Decision Making; Desire for food; Development; Development Plans; Diabetes Mellitus; Diet; Dietary Sugars; Endocrinology; Environment; Exposure to; Faculty; Feeding behaviors; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Grain; Grant; Growth; Health; Hospitals; Human Milk; Hyperphagia; Infant; Intake; Intervention Studies; Laboratories; Latino; Life; Link; Los Angeles; Machine Learning; Magnetic Resonance Imaging; Measures; Mediating; Mentored Research Scientist Development Award; Mentors; Mentorship; Metabolism; Milk; Modeling; Mothers; National Institute of Diabetes and Digestive and Kidney Diseases; Neighborhoods; Neuroanatomy; Neurocognitive; Neurologic; Obesity; Outcome; Pediatric Hospitals; Pediatric Research; Performance; Phenotype; Population; Postdoctoral Fellow; Prefrontal Cortex; Process; Protocols documentation; Puberty; Publications; Research; Research Personnel; Research Support; Resources; Rewards; Scientist; Short-Term Memory; Site; Solid; Source; Statistical Data Interpretation; Structure; Theoretical model; Thinness; Time; Training; United States National Institutes of Health; Variant; Ventral Striatum; Weight; Weight Gain; Youth; career; career development; cognitive development; cognitive neuroscience; cohort; computational neuroscience; critical developmental period; critical period; early-life nutrition; eating in absence of hunger; economic disparity; environmental disparity; executive function; experience; healthy weight; high body mass index; infant nutrition; innovation; insight; neurodevelopment; neuroimaging; neuroinflammation; novel; nutrition; obesity development; obesity in children; obesity risk; pediatric department; population based; programs; prospective; recruit; sex; skills; social disparities; social influence; statistics; sugar; tool; treatment program

Dr. Adise is an excellent and ideal candidate for an NIDDK Mentored Research Scientist Development Award. She is currently transitioning from a postdoctoral fellow on the NIH-funded Adolescent Brain Cognitive Development (ABCD) study to faculty in the Department of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism at Children’s Hospital of Los Angeles (CHLA). She has a strong publication and funding record and a unique combination of expertise across cognitive and computational neuroscience, nutrition, obesity, and pediatric ingestive behavior. The proposed research plan has three specific aims: 1) To characterize the temporal and directional cause vs. consequence relationship between neuroanatomical and functional associations of executive function and obesity development throughout adolescence; 2) To determine if developmental trajectories of executive function differ among populations with fewer neighborhood/ environmental resources linked to optimal child health and development. 3) To examine the contribution of infant nutrition to the development of executive function and appetite regulation during childhood. Dr. Adise has proposed an innovative study to address these aims that employs magnetic resonance imaging (MRI), novel statistical analyses (e.g., latent growth curve modeling, machine learning) and behavioral and biological markers of appetite regulation. The career development plan supports the research aims and Dr. Adise’s transition to independence with training in 1) neurocognitive development with respect to sex- and pubertal-specific influence on brain maturation; 2) social and environmental disparities (SED) and health; 3) Infant nutrition, appetite regulation, and body composition; and 4) Novel tools longitudinal data analysis. Her co-primary mentors, Drs. Elizabeth Sowell and Michael Goran are leading experts in the fields of neuroimaging, SED research, and infant nutrition and appetite regulation, respectively. Dr. Adise will also receive additional training with Dr. Kyung Rhee, a leading expert in translational mechanisms of executive functioning training in intervention research, and Dr. Joshua Millstein, an expert in longitudinal data analysis. CHLA is among the top 5 pediatric research hospitals in the USA and the population base consists of children who face extreme SEDs and health outcomes, including high rates of pediatric obesity. As one of Dr. Adise’s goals is to understand the influence of social and environmental disparities on obesity outcomes, CHLA is the perfect environment for Dr. Adise to accomplish her short- and long-term training and career goals. Dr. Adise has full backing and commitment from The Department of Pediatrics, which will continue to provide her with protected research time, a start-up package with significant funds, office and research space, and access to a wide array of research cores, including the MRI core as well as access to intramural funding programs. This award will help to establish the foundation on which Dr. Adise will build her expertise as a leading scientist in the field of neurocognitive development of pediatric ingestive behavior by providing the protected time to achieve the necessary training, experience, and mentorship.

Adise博士是NIDDK导师研究科学家发展奖的优秀和理想候选人。 她目前是美国国立卫生研究院资助的青少年大脑认知研究所的博士后研究员 发展(ABCD)研究对儿科，内分泌科，糖尿病，和 洛杉矶儿童医院(CHLA)的代谢。她有很好的出版和资助记录， 认知和计算神经科学、营养学、肥胖症和 儿童的进食行为。提出的研究计划有三个具体目标：1)表征时间 以及神经解剖学和功能关联之间的定向因果关系 执行功能与青春期肥胖的发展；2)确定是否发育 执行功能的轨迹在邻里/环境资源较少的人群中有所不同 与最佳儿童健康和发展挂钩。3)研究婴儿营养对儿童健康的贡献 儿童时期执行功能和食欲调节的发展。Adise博士提出了一种 解决这些目标的创新研究使用了磁共振成像(MRI)、新的统计学 分析(例如，潜在增长曲线建模、机器学习)以及行为和生物标记 食欲调节。职业发展计划支持研究目标和Adise博士过渡到 在1)关于性别和青春期特有影响的神经认知发展方面的独立性训练 关于大脑成熟；2)社会和环境差异(SED)与健康；3)婴儿营养、食欲 规则和身体成分；以及4)新的纵向数据分析工具。她的另一位小学导师Dr。 伊丽莎白·索厄尔和迈克尔·戈兰是神经成像、自发性精神障碍研究和婴儿领域的顶尖专家 营养调节和食欲调节。Adise博士还将接受Kyung Rhee博士的额外培训， 他是干预研究中执行功能训练的翻译机制方面的领先专家。 纵向数据分析专家约书亚·米尔斯坦说。中华儿科医院是全球五大儿科研究型医院之一。 在美国，人口基础由面临极端自闭症和健康后果的儿童组成，包括 儿童肥胖率高。因为Adise博士的目标之一是了解社会和文化的影响 肥胖结局的环境差异，CHLA是Adise博士成就她的完美环境 短期和长期的培训和职业目标。Adise博士得到了卫生部的全力支持和承诺 将继续为她提供受保护的研究时间，这是一个具有重要意义的创业方案 资金、办公室和研究空间，以及进入广泛的研究核心，包括核磁共振核心 作为获得校内资金计划的途径。这一奖项将有助于建立阿迪斯博士 将作为儿科消化神经认知发展领域的领先科学家积累专业知识 通过提供受保护的时间来实现必要的培训、经验和指导，来保护他们的行为。