An Integrative Approach to Evaluate Neurocognitive Disparities in Latinos Undergoing Treatment for Childhood Leukemia.
评估接受儿童白血病治疗的拉丁裔神经认知差异的综合方法。
基本信息
- 批准号:10651850
- 负责人:
- 金额:$ 61.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAccountingAcculturationAcute Lymphocytic LeukemiaAcute leukemiaAddressAdultAftercareAttentionBiologicalBiological FactorsChildChildhood Acute Lymphocytic LeukemiaChildhood LeukemiaClinicalClinical ManagementClinical OncologyDataDiagnosisDisparityDoctor of PhilosophyEducationEmploymentEnglish LanguageEnrollmentEnvironmentEpidemiologistEpidemiologyEthnic OriginEthnic PopulationEventFoundationsFundingGeneral PopulationGeneticGeographic LocationsGoalsGrantIncidenceIndividualInfrastructureInjuryInterventionLatinoLatino PopulationLeukemia Acute Lymphoblastic ChemotherapyLongitudinal cohortMalignant Childhood NeoplasmMeasuresModelingNative American AncestryNeighborhoodsNeurocognitiveNeurocognitive DeficitNeuropsychologyNewly DiagnosedOutcomeParticipantPatientsPerformancePhenotypePopulationPrincipal InvestigatorQuality of lifeRelapseResearchResearch PersonnelResourcesRiskRisk FactorsSamplingSeizuresShort-Term MemorySocioeconomic FactorsSocioeconomic StatusSurvivorsSymptomsTimeTreatment-related toxicityWorkYouthbilingualismcerebrovascularcohortdesigndisparity reductioneconomic outcomeethnic disparityexecutive functionexperiencehealth disparityimprovedimproved outcomeinattentionmulti-ethnicmultidisciplinaryneurotoxicneurotoxicitynon-geneticnovelpatient populationprocessing speedprotective factorsrecruitresponsesocial health determinantssocioeconomicssurvivorshiptranslational potentialtreatment adherencetreatment comparisontreatment disparitytreatment responsewhite matter injury
项目摘要
PROJECT SUMMARY/ABSTRACT
Latino children experience increased incidence of acute lymphoblastic leukemia (ALL), as well as disparities
in treatment response, relapse, and survival. However, to date, there have been few studies evaluating the
impact of persistent neurocognitive symptoms on educational and economic outcomes in Latino survivors. What
has been demonstrated by our group and others is that disparities among Latino children with ALL are not fully
explained by non-genetic factors, such as differences in treatment adherence. In fact, biological factors
contribute to these outcomes: Native American genetic ancestry has been implicated in relapse among Latinos
with ALL and is related to neurotoxicity during treatment. Building from this work, we explore two unanswered
questions: 1) what is the burden of neurocognitive deficits among Latino children diagnosed with ALL relative to
non-Latino children, and 2) what is the relative contribution of clinical, socioeconomic, cultural, and biological
factors in explaining neurocognitive disparities among childhood ALL survivors. We will leverage our ongoing
Reducing Ethnic Disparities in Acute Leukemia (REDIAL) cohort to conduct deep neurocognitive phenotyping in
a subset of the population (N=400) diagnosed and treated for ALL – with a particular focus on Latinos, who make
up more than 50 percent of the ongoing cohort. We will model neurocognitive performance from diagnosis
through 7 years post-diagnosis by employing an accelerated longitudinal cohort design, which includes annual
assessments for: 1) newly diagnosed patients in the first years of the grant (Wave 1, n = 200); and 2) survivors
who are 3-7 years post diagnosis (Wave 2, n = 200). We also incorporate factors that have yet to be included in
models of neurocognitive outcomes among children diagnosed with ALL, such as measures of socioeconomic
status (SES), acculturation, English-language proficiency, and genetic ancestry. Our research aims are to: 1)
characterize the trajectory of neurocognitive performance in Latino children diagnosed with ALL; 2) examine the
impact of clinical, individual and neighborhood socioeconomic factors, and level of acculturation among Latinos;
and 3) assess the relative contribution of genetic ancestry to neurocognitive performance in children diagnosed
with ALL. Strengths of our approach include rigorous preliminary data, a recruitment infrastructure for enrolling
Latino patients diagnosed with ALL, existing data and samples collected as part of our ongoing REDIAL cohort,
an unparalleled research environment, and a geographical region that is ethnically and socioeconomically
diverse. This proposal has significant translational potential to improve the clinical management of
neurocognitive outcomes in this population, as it will identify children at risk for neurocognitive difficulties and in
greatest need of intervention, critical points in treatment/survivorship when intervention strategies may help to
mitigate disparities in neurocognitive outcomes, and targets for intervention.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Austin L Brown其他文献
Evaluation of Methotrexate Pharmacogenomic Variants to Predict Acute Neurotoxicity in Children with Acute Lymphoblastic Leukemia
- DOI:
10.1182/blood-2024-200891 - 发表时间:
2024-11-05 - 期刊:
- 影响因子:
- 作者:
Austin L Brown;Rachel Harris;Olga A Taylor;Mark Zobeck;Melanie Brooke Bernhardt;Maria Monica Monica Gramatges;Ashley Chavana;Alanna Morrison;Kathleen Ludwig;Laura J. Klesse;Kenneth Matthew Heym;Timothy Griffin;Rodrigo Erana;Juan C. Bernini;Han Chen;Bing Yu;Melissa A. Richard;Philip J Lupo;Karen R Rabin;Michael E. Scheurer - 通讯作者:
Michael E. Scheurer
Neighborhood design and body mass: Does weight status differ between a new urbanist and conventional suburban neighborhoods?
社区设计和体重:新都市主义社区和传统郊区社区的体重状况是否有所不同?
- DOI:
- 发表时间:
2005 - 期刊:
- 影响因子:0
- 作者:
Austin L Brown - 通讯作者:
Austin L Brown
A Clinical and Sociodemographic Risk Prediction Model Evaluating Adherence to Long-Term Care in Survivors of Childhood Leukemia
- DOI:
10.1182/blood-2022-167244 - 发表时间:
2022-11-15 - 期刊:
- 影响因子:
- 作者:
Austin L Brown;Heidi V Russell;Abiodun Oluyomi;Michelle Fritsch;Kayla Foster;Omar Shakeel;Shawki Lotfi Qasim;Fatih Okcu;Maria Monica Monica Gramatges - 通讯作者:
Maria Monica Monica Gramatges
Increasing Obesity, Increasing Challenges: The Link between Obesity and Cancer
肥胖日益增加,挑战日益增加:肥胖与癌症之间的联系
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
Austin L Brown;Shine Chang - 通讯作者:
Shine Chang
Epigenetic Age Acceleration and Risk for Chronic Health Conditions in a Diverse Cohort of Survivors of Childhood Acute Lymphoblastic Leukemia
- DOI:
10.1182/blood-2022-169730 - 发表时间:
2022-11-15 - 期刊:
- 影响因子:
- 作者:
Melissa A Richard;Rachel M Harris;Philip J. Lupo;Austin L Brown;Maria Monica Monica Gramatges - 通讯作者:
Maria Monica Monica Gramatges
Austin L Brown的其他文献
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{{ truncateString('Austin L Brown', 18)}}的其他基金
A Systems Epidemiology Approach for Predicting Methotrexate Neurotoxicity in Pediatric Acute Leukemia
预测儿童急性白血病甲氨蝶呤神经毒性的系统流行病学方法
- 批准号:
10655716 - 财政年份:2023
- 资助金额:
$ 61.46万 - 项目类别:
Etiology and impact of ethnic disparities in therapy-associated hepatotoxicity among children and adolescents treated for ALL
接受 ALL 治疗的儿童和青少年中治疗相关肝毒性的病因学和种族差异的影响
- 批准号:
10683986 - 财政年份:2021
- 资助金额:
$ 61.46万 - 项目类别:
Etiology and impact of ethnic disparities in therapy-associated hepatotoxicity among children and adolescents treated for ALL
接受 ALL 治疗的儿童和青少年中治疗相关肝毒性的病因学和种族差异的影响
- 批准号:
10289495 - 财政年份:2021
- 资助金额:
$ 61.46万 - 项目类别:
Etiology and impact of ethnic disparities in therapy-associated hepatotoxicity among children and adolescents treated for ALL
接受 ALL 治疗的儿童和青少年中治疗相关肝毒性的病因学和种族差异的影响
- 批准号:
10472698 - 财政年份:2021
- 资助金额:
$ 61.46万 - 项目类别:
Integrative Molecular Epidemiology of Neurocognitive Outcomes in Acute Lymphoblastic Leukemia
急性淋巴细胞白血病神经认知结果的综合分子流行病学
- 批准号:
10381514 - 财政年份:2018
- 资助金额:
$ 61.46万 - 项目类别:
Integrative Molecular Epidemiology of Neurocognitive Outcomes in Acute Lymphoblastic Leukemia
急性淋巴细胞白血病神经认知结果的综合分子流行病学
- 批准号:
9901471 - 财政年份:2018
- 资助金额:
$ 61.46万 - 项目类别:
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