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中文摘要
翻译
Robin寡转移中心致力于了解放射治疗如何 影响低体积前列腺癌(PCA)的转移过程。管理核心(管理核心) 领导层将是Phuoc Tran,M.D.,Ph.D.(联系Pi)和Isabel Lauren Jackson(MPI)。Tran博士是副主席 他是马里兰大学(UM)放射肿瘤学教授和研究专家。他是一个放射线的实践者 因其使用立体定向放射治疗的创新临床试验而获得国际认可的肿瘤学家 少转移性主成分分析。杰克逊博士是非临床放射生物学实验室(NRBL)的主任, 放射肿瘤科转译放射科学处处长 在密歇根大学。她在管理数百万美元的联邦合同研究项目方面拥有丰富的经验 组织损伤和辐射对策。项目领导层由经验丰富且坚强的 调查小组:分子表征试验MCT由Phuoc Tran博士和Mark Mishra博士领导;项目1 (基因组学、放射组学和液体活检)将由Phuoc Tran、Amit Sawant和Lei Ren博士领导;项目2 (代谢组学和差异)将由尼科尔·西蒙博士领导,副主任兼 托马斯·杰斐逊大学(TJU)的放射肿瘤学;将领导资源和交叉培训中心 由威尔-康奈尔医学(WCM)的Luigi Marchionni博士、UM的Amit Sawant和Lei Ren博士撰写。支座 行政核心部门的Tran博士和Jackson博士将担任项目经理(戴安娜·纽曼饰)。纽曼女士已经 支持类似计划的重要经验,包括组织现场访问、外展交流、 组织研讨会,并与NIH、BARDA和DARPA进行协调。我们的行政核心的使命 确保研究项目和研究核心能够有效地合作,设定优先事项 项目间协作,跨分析平台验证机制,并交流研究结果 内部和外部。我们寻求成为NCI Robin计划的动态贡献者,与 NCI和癌症研究社区,并成为患者权益倡导者的合作伙伴,将基础研究联系起来 以改善患者的预后。罗宾寡妇中心的领导层坚定地致力于指导 辐射和转移研究的下一代领导者。我们的罗宾寡妇中心包括两个 职业生涯中期的新兴领导者,作为分子表征试验负责人(Mishra博士)和核心主任(Dr.Mishra博士) 马尔基奥尼)。我们的罗宾寡核苷酸中心得到了密歇根大学放射肿瘤科和基金的资助 从UMSOM到早期阶段的教员和理科背景不足的教员(UIS)。我们的 管理核心将通过三个目标实现这些目标。目标1:科学和财务管理 罗宾寡妇中心。目标2:沟通和审查:外部咨询委员会(内部咨询委员会) 咨询委员会(IAC)、患者权益倡导者和NCI。目标3:以ESI和ESI为重点的试点研究补助金 多样性。
英文摘要
The ROBIN Oligometastasis (ROBIN OligoMET) Center is focused on understanding how radiation therapy can affect the metastatic process in low-volume prostate cancer (PCa). The Administrative Core (Admin Core) leadership will be Phuoc Tran, M.D., Ph.D. (Contact PI) and Isabel Lauren Jackson (MPI). Dr. Tran is Vice Chair for Research and Professor of Radiation Oncology at the University of Maryland (UM). He is a practicing radiation oncologist with international recognition for his innovative clinical trials using stereotactic radiation in oligometastatic PCa. Dr. Jackson is the Director of the Nonclinical Radiation Biology Laboratory (NRBL) and Director of the Division of Translational Radiation Sciences (DTRS) within the Department of Radiation Oncology at UM. She has deep experience in managing multimillion-dollar federal contract-research programs on normal tissue injury and radiation countermeasures. Project leadership comprises a highly experienced and strong investigative team: Molecular Characterization Trial MCT is led by Drs. Phuoc Tran and Mark Mishra; Project 1 (Genomics, radiomics and liquid biopsies) will be led by Drs. Phuoc Tran, Amit Sawant and Lei Ren; Project 2 (Metabolomics and disparities) will be led by Dr. Nicole Simone Vice Chair for Research and Professor of Radiation Oncology at the Thomas Jefferson University (TJU); Resource and Cross-Training Cores will be led by Drs. Luigi Marchionni from Weill-Cornell Medicine (WCM), Amit Sawant and Lei Ren from UM. Supporting Drs. Tran and Jackson in the Administrative Core will be a Project Manager (Diana Newman). Ms. Newman has significant experience supporting similar programs including organizing site visits, outreach communications, organizing symposia, and coordination with NIH, BARDA and DARPA. The mission of our Administrative Core is to ensure that the research Projects and Research Cores are able to work together efficiently, set priorities for inter-Project collaborations, validate mechanisms across profiling platforms, and communicate research results internally and externally. We seek to be dynamic contributors to the NCI ROBIN Program, to collaborate with the NCI and the cancer research community, and to be a partner with patient advocates to connect basic research to improved patient outcomes. The leadership of ROBIN OligoMET Center is strongly committed to mentoring the next generation of leaders in radiation and metastasis research. Our ROBIN OligoMET Center includes two mid-career emerging leaders as Molecular Characterization Trial Leader (Dr. Mishra) and Core Director (Dr. Marchionni). Our ROBIN OligoMET Center has funding from the UM Radiation Oncology Department and funds from UMSOM to target early stage faculty and faculty from backgrounds underrepresented in science (UIS). Our Admin Core will achieve these goals through three Aims. Aim 1: Scientific and Financial Management of the ROBIN OligoMET Center. Aim 2: Communication and Review: External Advisory Committee (EAC), Internal Advisory Committee (IAC), Patient Advocates, and NCI. Aim 3: Pilot Research Grants Focusing on ESI and Diversity.
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Administrative Core
  • 批准号:
    10676852
  • 项目类别:
  • 资助金额:
    $34.65万
  • 财政年份:
    2022
  • 负责人:
    Phuoc T. Tran
  • 依托单位:
Phase 2 randomized Total Eradication of metastatic lesions following definitive Radiation to the Prostate in de novo oligometaStatic prostate cancer (TERPS) trial
  • 批准号:
    10515451
  • 项目类别:
  • 资助金额:
    $36.74万
  • 财政年份:
    2022
  • 负责人:
    Phuoc T. Tran
  • 依托单位:
Phase 2 randomized Total Eradication of metastatic lesions following definitive Radiation to the Prostate in de novo oligometaStatic prostate cancer (TERPS) trial
  • 批准号:
    10676858
  • 项目类别:
  • 资助金额:
    $21.74万
  • 财政年份:
    2022
  • 负责人:
    Phuoc T. Tran
  • 依托单位:
Radiation modulation of cell plasticity programs determine prostate cancer oligometastatic potential
  • 批准号:
    10515452
  • 项目类别:
  • 资助金额:
    $28.52万
  • 财政年份:
    2022
  • 负责人:
    Phuoc T. Tran
  • 依托单位:
海外基金