COMParative ASSessment of p16/Ki-67 DUal Staining Technology in women living with HIV (COMPASS-DUST study)
p16/Ki-67 双重染色技术对 HIV 感染女性的比较评估(COMPASS-DUST 研究)
基本信息
- 批准号:10534893
- 负责人:
- 金额:$ 9.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-20 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccreditationAcetic AcidsAddressAdoptionAdultAfricaAfrica South of the SaharaAnxietyCervicalCervical Cancer ScreeningCervical Intraepithelial NeoplasiaClient satisfactionClinicalClinical TrialsCollaborationsColposcopyComparative StudyCytologyDNADataDetectionDiagnosisDiscipline of obstetricsDiseaseEffectivenessEnrollmentEpidemiologyEvaluationFrightFutureGoalsGrantGynecologyHIVHIV SeronegativityHIV riskHPV-High RiskHuman PapillomavirusHuman papillomavirus 16Interdisciplinary StudyJournalsMalignant NeoplasmsMalignant neoplasm of cervix uteriManuscriptsMedicineMentorsMethodsMolecularNigeriaPap smearParticipantPerformancePhysiciansPositioning AttributeProgram DevelopmentProspective cohort studyProtocols documentationPublic HealthPublic Health Applications ResearchPublic Health PracticePublicationsRecommendationResearchResearch ActivityResearch DesignResearch PersonnelResearch Project GrantsResource-limited settingResourcesRiskSamplingScientistScreening procedureSecureSeveritiesSpecificityStainsTechnologyTestingTimeTrainingTraining ActivityTraining ProgramsTransferable SkillsTranslatingTriageUnited StatesUniversitiesVaginaVisualWomanWorld Health OrganizationWritingagedbasecareercareer developmentcollegecomparativecostcost effectivenessdesigndiagnostic accuracyepidemiology studyexperiencefollow-upimprovedinnovationinterestlecturerperformance testspreventprogramsrapid testreproductive tractresearch and developmentscreeningsexually activeskillstreatment centeruptake
项目摘要
Project Summary
This application presents a five-year career development and research program for an early career investigator
from Nigeria. The candidate, Kehinde Okunade, is a 2018 Fogarty fellow through the HBNU FIC D43 Training
Program and also a Senior Lecturer in Obstetrics and Gynecology at the College of Medicine of the University
of Lagos in Nigeria. The goals of his application are to use the protected time provided through the program to
(1) Build and strengthen mentoring relationships and skills transfer through regular interactions with mentors
and co-mentors; (2) Acquire experiential skills in clinical epidemiologic research and be able to translate this to
public health practice (3) Conduct the rigorous research proposed in the application; (4) Acquire skills in the
design and conduct of end-to-end clinical trials; (5) Establish research collaboration network and effectively
coordinate multidisciplinary research projects, and (6) Be able to write, secure, and manage grants to conduct
studies as well as write manuscripts for publication in high-impact journals.
The proposed research in the FIC K43 application, “COMParative ASSessment of p16/Ki-67 DUal Staining
Technology in women living with HIV (COMPASS-DUST)” is the first in sub-Saharan Africa (sSA) that aims to
evaluate the performance of p16/Ki-67 dual staining technology (DUST) in cervical cancer screening among
women living with HIV (WLHIV). In Aim 1 and 2, using an intra-participant comparative study design, we will
enrol n=300 sexually active WLHIV aged 25–65 years at two accredited adult HIV treatment centres in Lagos,
Nigeria to compare the performance of DUST to the currently used screening methods (Pap smear, hr-HPV
DNA, or VIA testing) in detecting high-grade cervical intraepithelial neoplasia (CIN2/3). In Aim 3, we will use a
prospective cohort study design to enrol WLHIV (n=60) who are diagnosed as having low-grade CIN (CIN1) for
a 6-monthly follow-up for 2 years to detect persistent CIN1 and progression of CIN1 to CIN2/3. The findings of
this study will be of great public health significance for 2 reasons. First, they may provide evidence of the
existence of a better performance screening method for the primary and triage detection of CIN2/3 in WLHIV.
Secondly, we may demonstrate that this high-performance test can improve the long-term predictive accuracy
of screening by extending the intervals between evaluations and thus decrease the overall cost and increase
screening uptake in WLHIV.
This application will build on the candidate’s background experience and the expertise of his team of mentors
and co-mentors in Nigeria and the US to achieve the training and research goals of this program. In the long-
term, the proposed research and training activities will provide the candidate with a unique set of experiential
skills that will enable him to transition to independence as a physician-scientist.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
KEHINDE SHARAFADEEN OKUNADE其他文献
KEHINDE SHARAFADEEN OKUNADE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('KEHINDE SHARAFADEEN OKUNADE', 18)}}的其他基金
COMParative ASSessment of p16/Ki-67 DUal Staining Technology in women living with HIV (COMPASS-DUST study)
p16/Ki-67 双重染色技术对 HIV 感染女性的比较评估(COMPASS-DUST 研究)
- 批准号:
10669781 - 财政年份:2022
- 资助金额:
$ 9.52万 - 项目类别:
相似海外基金
Photodecarboxylation of coumarinyl acetic acids
香豆素乙酸的光脱羧
- 批准号:
382526-2009 - 财政年份:2009
- 资助金额:
$ 9.52万 - 项目类别:
University Undergraduate Student Research Awards
Photodecarboxylation of Coumarinyl Acetic Acids
香豆素乙酸的光脱羧
- 批准号:
351783-2007 - 财政年份:2007
- 资助金额:
$ 9.52万 - 项目类别:
University Undergraduate Student Research Awards














{{item.name}}会员




