Pelvic Floor Disorders Network 2021

盆底疾病网络V周期更新-德克萨斯大学西南分校 项目摘要/摘要 我们的主要目标是积极参与盆底疾病网络(PFDN)，通过有效的 在所有研究中招募、参与和保留种族和民族多样化的患者群体 检查女性盆底疾病(PFDs)。我们的第二个目标是将创新的研究建议带到 该网络强调翻译目的，探索PFDs的病理生理学和预防 明确界定的临床研究人群。最终目标是作为主要站点领导一项研究预防的多中心试验 尿失禁和大便失禁。为了实现这些目标，我们描述了以下条件和经验 该大学的女性骨盆医学和重建外科(FPMRS)教员和研究团队 德克萨斯西南医疗中心和帕克兰医院的设施和患者人数 执行临床方案和我们最先进的科学方法来研究PFDs。我们的临床和 研究诊所既为医疗贫困患者(Parkland医院)服务，也为私人参保患者服务 (大学实践)在美国南部。这些诊所提供了多样化的患者群体，这使得我们能够 继续担任人阵中拉美裔妇女的主要招聘人员。在整个周期III和IV中，即使不是 作为一个完整的临床站点(周期III)，我们一直致力于成功保留和长期随访 我们的人阵研究参与者。在第四周期中，我们积极参与了人阵的所有方面，包括概念 提案、委员会参与和稿件准备。我们研究团队的独特之处在于泌尿外科 基础和翻译科学家，我们的网站领导了管理和指导生物仓库的工作 民阵已在德克萨斯大学西南分校驻扎了15年，并已成为多个 最近的翻译研究努力。此外，我们妇产科内的科学资源和基础设施 该部门集中关注蛋白质组学、基因组学、表观遗传学和基因调控在各种疾病中的作用 妇女健康的方方面面。此外，我们继续通过多个出版物和 持续的写作团队参与。自2015年以来，德克萨斯大学西南分校和德克萨斯大学西南分校都开设了新医院 帕克兰，FPMRS诊所的人口基数一直在激增。德克萨斯大学西南分校的FPMRS医生 继续致力于严格的对照试验，旨在客观地评估非手术和非手术治疗的原则 符合人阵使命的外科护理。随着不断增长的多样化临床患者群体， 忠诚和经验丰富的研究团队，具有成功的内部和外部合作血统，以及 支持额外的翻译PFD研究的资源和专业知识，德克萨斯大学西南分校已经准备好 充满活力地继续在人阵作为临床地点。

Pelvic Floor Disorders Network Cycle V Renewal – UT Southwestern PROJECT SUMMARY / ABSTRACT Our primary goal is to actively engage in the Pelvic Floor Disorders Network (PFDN) through efficient patient recruitment, participation, and retention of a racially and ethnically diverse patient population in all studies examining pelvic floor disorders (PFDs) in women. Our second goal is to bring innovative research proposals to this Network with emphasis on translational aims that explore the pathophysiology and prevention of PFDs in well-defined clinical study populations. A final goal is to lead as primary site a multicenter trial studying prevention of urinary and fecal incontinence. To accomplish these aims, we describe the qualifications and experience of the Female Pelvic Medicine and Reconstructive Surgery (FPMRS) faculty and research teams at the University of Texas Southwestern Medical Center and Parkland Hospital, the facilities and patient population available to carry out clinical protocols, and our state-of-the-art scientific approaches to the study of PFDs. Our clinical and research clinics serve both medically indigent patients (Parkland Hospital) and private, insured patients (university practice) in the southern US. These clinics provide a diverse patient population which has allowed us to continually be the lead recruiter of Latina women in the PFDN. Throughout Cycles III and IV, even when not a full clinical site (Cycle III), we have remained committed to the successful retention and long-term follow-up of our PFDN study participants. In Cycle IV, we actively partnered in all aspects of the PFDN including concept proposal, committee participation, and manuscript preparation. Unique to our research team are urogynecology basic and translational scientists whereby our site has led the effort to manage and direct the Biorepository for the PFDN, which has remained housed at UT Southwestern for 15 years and has become integral to multiple recent translational research endeavors. Further, the scientific resources and infrastructure within our Ob/Gyn department are centrally focused on the role of proteomics, genomics, epigenetics and gene regulation in various aspects of women’s health. Moreover, we continue to contribute scientifically with multiple publications and ongoing writing team participation. Since 2015, when new hospitals opened for both UT Southwestern and Parkland, the FPMRS clinic population base has been surging. The FPMRS physicians at UT Southwestern remain dedicated to rigorous controlled trials intended to objectively evaluate principles of non-surgical and surgical care consistent with the mission of the PFDN. With a growing, diverse clinical patient population, a committed and seasoned research team with a pedigree of successful internal and external collaborations, and the resources and expertise to champion additional translational PFD research, UT Southwestern is ready and energized to continue in the PFDN as a clinical site.