Undergraduate Clinical Scholars Program: Pathway to Clinical Research Careers

本科临床学者计划：临床研究职业之路

• 批准号: 10558215
• 负责人: James D Lewis
• 金额: $ 10.8万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10558215
• 关键词: Address; Admission activity; Advisory Committees; Award; Awareness; Basic Science; Behavioral Sciences; Bioinformatics; Biomedical Research; Biometry; COVID-19 pandemic; Career Choice; Clinical; Clinical Investigator; Clinical Research; Clinical Services; Clinical Trials; Communication; Comparative Effectiveness Research; Competence; Coupled; Decision Making; Decision Modeling; Degree program; Development; Diabetes Mellitus; Discipline; Disease; Early Intervention; Economics; Educational Curriculum; Educational workshop; Endocrine; Environment; Epidemiology; Ethics; Exposure to; Faculty; Fellowship; Fostering; Funding; Geography; Goals; Gold; Graduate Education; Health; Health Services Research; Home; Human; Industry; Infrastructure; Institutes; Institution; Kidney; Knowledge; Laboratories; Lead; Link; Liver; Medical; Medical Device; Medicine; Mentors; Mentorship; Methods; Mission; NCI Scholars Program; National Institute of Diabetes and Digestive and Kidney Diseases; Observational epidemiology; Outcome; Output; Pancreas; Participant; Pathway interactions; Patients; Peer Review; Pennsylvania; Persons; Pharmacologic Substance; Population; Procedures; Public Health; Public Policy; Publications; Research; Research Methodology; Research Project Grants; Resources; Scholarship; Schools; Science; Scientist; Social Sciences; Strategic Planning; Structure; Students; Surveys; Talents; Training; Translational Research; Underrepresented Minority; United States; United States Food and Drug Administration; United States National Institutes of Health; Universities; Woman; Work; Workforce Development; Writing; base; career; clinical center; clinical epidemiology; clinical investigation; cohort; design; diabetic; disability; disadvantaged background; drug development; epidemiology study; experience; faculty mentor; health economics; implementation science; improved; innovation; interest; investigator training; lectures; medical schools; meetings; member; minority student; next generation; novel strategies; population health; programs; recruit; research study; response; skills; statistics; student mentoring; success; summer program; symposium; undergraduate research experience; undergraduate student

PROJECT SUMMARY The translation of research from the bedside to real-world practice utilizing disciplines including disease epidemiology, biostatistics, comparative effectiveness research, evidence synthesis, decision modeling, quality improvement, and implementation science is essential to improve the health of populations. The NIH, FDA and other organizations have increasingly recognized the importance of this broader sense of translational research. However, the pool of clinician investigators trained to perform such research is limited, particularly in the fields encompassed by the mission of the NIDDK. Training in these disciplines requires the same rigor as traditional “wet-bench” research; and undergraduate exposure and training in public health and epidemiology are relatively uncommon, leading to a significant underrepresentation of these fields in graduate training. This shortage of qualified clinical investigators is particularly evident among women and underrepresented minorities, a key focus of the 2021 NIDDK Strategic Plan for Research. To address these needs, in 2017 we established the Undergraduate Clinical Scholars Program (UCSP), an innovative undergraduate research opportunity (URO) at the University of Pennsylvania. The specific aims of the UCSP are two-fold: Aim1. To foster a strong interest among talented undergraduates in human clinical research with a focus on digestive, pancreatic, liver, kidney, and diabetes research; and Aim 2. To establish durable mentoring relationships between talented undergraduates interested in pursuing clinical research and supportive faculty mentors. The cornerstone of the UCSP is an intensive clinical- research experience that entails close interaction with and mentorship by a UCSP faculty member. UCSP students also complete a structured curriculum in epidemiology and biostatistics that is enhanced with a statistics laboratory and lectures/discussion groups in ethics, scientific writing and pathways to medical school admissions (MD and combined degree programs). The in person program culminates with a formal research symposium where students present and defend their work. The UCSP infrastructure provides administrative support to help sustain the mentorship relations after the summer program. The highly competitive program receives approximately 500 applicants per year. To date, we have had 28 UCSP students including 13 underrepresented minorities and 15 women. Students have been involved in 13 peer-reviewed publications, received a number of honors including 2 Marshall Scholarships, and 8 students are currently in medical school with another 8 applying this year. In aggregate, this innovative URO has successfully provided superb faculty, exceptional scientific resources and exciting intellectual environment for trainees to be exposed to and expand their knowledge and interest in clinical and health services research with a key outcome to motivate trainees in clinical research careers with a focus on digestive, pancreatic, liver, kidney and endocrine related research.

项目概要 利用包括疾病在内的学科将研究从床边转化为现实世界的实践 流行病学、生物统计学、比较有效性研究、证据综合、决策模型、质量 改进和实施科学对于改善人口健康至关重要。美国国立卫生研究院、FDA 和其他组织越来越认识到这种更广泛意义上的转化的重要性 研究。然而，接受过此类研究培训的临床研究人员数量有限，特别是在 NIDDK 使命所涵盖的领域。这些学科的培训需要与 传统的“湿台”研究；以及公共卫生和流行病学方面的本科生接触和培训 相对不常见，导致这些领域在研究生培训中的代表性严重不足。这 合格临床研究人员的短缺在女性中尤为明显且代表性不足 少数民族是 2021 年 NIDDK 研究战略计划的重点。 为了满足这些需求，我们于 2017 年建立了本科临床学者计划 (UCSP)， 宾夕法尼亚大学的创新本科生研究机会（URO）。具体目标 UCSP 有两个目标： 目标 1。培养优秀本科生对人文学科的浓厚兴趣 临床研究，重点是消化、胰腺、肝脏、肾脏和糖尿病研究；和目标 2。 在有兴趣追求的有才华的本科生之间建立持久的指导关系 临床研究和支持性导师。 UCSP 的基石是强化临床- 需要与 UCSP 教员密切互动并接受其指导的研究经验。加州大学伯克利分校 学生还完成了流行病学和生物统计学的结构化课程，并通过以下课程得到加强： 统计实验室和伦理学、科学写作和医学院升学方面的讲座/讨论小组 招生（医学博士和联合学位课程）。面对面的项目以正式的研究结束 学生展示并捍卫他们的作品的研讨会。 UCSP 基础设施提供管理 支持在暑期项目结束后帮助维持师徒关系。竞争激烈的项目 每年接待约 500 名申请者。迄今为止，我们已有 28 名 UCSP 学生，其中 13 名 代表性不足的少数族裔和 15 名妇女。学生参与了 13 篇同行评审出版物， 获得包括2项马歇尔奖学金在内的多项荣誉，目前有8名学生在医学院就读 今年还有 8 人申请。总的来说，这个创新的 URO 成功地提供了一流的师资力量， 卓越的科学资源和令人兴奋的智力环境，供学员接触和拓展 他们对临床和卫生服务研究的知识和兴趣，其关键成果可以激励学员 临床研究职业，重点是消化、胰腺、肝脏、肾脏和内分泌相关研究。