Activating transcription factor 3 and cancer progression

激活转录因子 3 和癌症进展

• 批准号: nhmrc : 1066665
• 负责人: A/Pr Elizabeth Williams
• 金额: $ 51.2万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activating-transcription-factor-cancer-progression/455252
• 关键词: Activating; transcription; factor; cancer; progression

We have shown that the transcription factor ATF3 suppresses bladder cancer spread. Turning off ATF3 is associated with disease progression in bladder and colorectal cancer. We will test whether levels of ATF3 can be used as a prognostic maker for disease progression, investigate the mechanisms underlying the actions of ATF3 in bladder and colorectal cancer and test whether therapeutically activating ATF3 can inhibit cancer progression.

我们已经表明，转录因子ATF3抑制膀胱癌扩散。关闭ATF 3与膀胱癌和结直肠癌的疾病进展相关。我们将测试ATF3的水平是否可以用作疾病进展的预后指标，研究ATF3在膀胱癌和结直肠癌中的作用机制，并测试治疗激活ATF3是否可以抑制癌症进展。