Product Evaluation and Manipulation Core (PEMC)

项目总结--产品评估和操作核心 产品评估和操作核心(PEMC)的目标是支持和补充人类 在项目(P1-P4)中进行的研究和需要向周围的证据基础提供信息的试点研究 尼古丁的三个维度(浓度、形态和异构体)如何影响烟草产品的吸引力， 成瘾性和毒性。我们的中心专注于具有可信的潜在危害的新型烟草产品 现有吸烟者或无烟烟草使用者的减少。然而，存在显著的数据差距 关于主要产品特征和对非用户的吸引力；鉴于其高流行率，这是令人担忧的 使用量和最近销量的快速增长。PEMC将生成产品表征数据，在 与P1-P4结果一致，将实现我们中心的目标：提供必要的证据，以澄清 在现有烟草产品使用中有效减少危害的途径，同时限制了新奇的吸引力 青少年和成年人从不吸烟的烟草产品。对烟草产品设计的深刻理解 特性，包括化学、物理和细菌特性，是行业消费者的核心 响应模型。因此，PEMC在我们中心的综合主题中发挥着关键作用 脚本“：使用行业的尼古丁剧本最大限度地提高公共健康，因为我们努力产生 推动监管政策最大化公共健康而不是行业销售所需的数据。PEMC特有的 目的是1)精确地操纵EC液体中的三个尼古丁维度，以评估它们对人类的影响 行为、主流排放和细胞毒性；以及2)使用一系列物理化学分析 烟草产品中尼古丁含量、其他成分和污染物的量化方法，以及3) 排放中的有害和潜在有害成分和其他毒物。PEMC将由PMC教授领导。 玛丽埃尔·布林克曼和艾哈迈德·埃尔·海拉尼博士，他们在操纵和刻画角色方面拥有丰富的经验 烟草产品为烟草监管科学中心和独立机构的烟草监管提供信息 资助金。OSU-TCORS PEMC提出了一套高度集成和多样化的物理化学分析 能力，在操纵烟草产品方面的成功记录，为监管提供信息，以及强大的 强调通过强大的质量控制程序对所有测量结果进行鉴定。

PROJECT SUMMARY – PRODUCT EVALUATION AND MANIPULATION CORE The goal of the Product Evaluation and Manipulation Core (PEMC) is to support and complement the human research conducted in the Projects (P1-P4) and pilot studies needed to inform the evidence base surrounding how the three nicotine dimensions (concentration, form, and isomer) affect tobacco product appeal, addictiveness, and toxicity. Our Center focuses on novel tobacco products that have a credible potential for harm reduction in established cigarette smokers or smokeless tobacco users. However, there are significant data gaps regarding key product characteristics and appeal to nonusers; which is concerning given their high prevalence of use and recent rapid increase in sales. The PEMC will generate product characterization data, which, in concert with P1-P4 results, will accomplish our Center's objective: provide the evidence needed to clarify a pathway for meaningful harm reduction in established tobacco product use, while limiting the appeal of novel tobacco products for youth and adult never smokers. A firm understanding of tobacco product design characteristics, including chemical, physical, and bacterial properties, is central to the Industry's Consumer Response Model. Therefore the PEMC plays a critical role in our Center's integrative theme “Flipping the Script”: Using the Industry's Nicotine Playbook to Maximize Public Health, as we endeavor to generate the data needed to fuel regulatory policies that maximize public health and not industry sales. The PEMC specific aims are to 1) Precisely manipulate the three nicotine dimensions in EC liquids to evaluate their effect on human behaviors, mainstream emissions, and cellular toxicity; and 2) Employ an array of physicochemical analytical methods to quantify nicotine dimensions, other ingredients, and contaminants, in tobacco products, and 3) harmful and potentially harmful constituents and other toxicants in their emissions. The PEMC will be led by Prof. Marielle Brinkman and Dr. Ahmad El Hellani, who have extensive experience manipulating and characterizing tobacco products to inform tobacco regulation in both Tobacco Regulatory Science Center and standalone grants. The OSU-TCORS PEMC proposes a highly integrated and diverse set of physicochemical analytical capabilities, a successful track record in the manipulation of tobacco products to inform regulation, and a strong emphasis on qualifying all measurements with a robust quality control program.