E-PROOF: E-intervention for Protein Intake and Resistance Training to Optimize Function

E-PROOF：蛋白质摄入和阻力训练的电子干预以优化功能

• 批准号: 10665172
• 负责人: Jessica L. Krok-Schoen
• 金额: $ 23.63万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665172
• 关键词: Acceleration; Accounting; Address; Adherence; Age; Aging; Arthritis; Behavior Therapy; COVID-19 pandemic; Calories; Cancer Intervention; Cancer Patient; Cancer Survivor; Cancer Survivorship; Clinical; Comprehensive Cancer Center; Consumption; Control Groups; Counseling; Coupled; Data; Development; Diet; Dietary Intervention; Dietary intake; Dietitian; Education; Educational Intervention; Educational Materials; Elderly; Exercise; Fatigue; Geriatrics; Goals; Health; Health Care Costs; Health Promotion; Health behavior; Heart Diseases; Heart Rate; Impairment; Incidence; Intake; Intervention; Knowledge; Lead; Lung diseases; Malignant Neoplasms; Mission; Muscle Proteins; Muscular Atrophy; Nutritional; Obesity; Ohio; Outcome; Outcome Study; Pain; Participant; Physical Function; Physical assessment; Population; Predisposition; Prevalence; Process; Protein Biosynthesis; Proteins; Public Health; Randomized; Randomized, Controlled Trials; Recommendation; Recording of previous events; Research; Risk; Risk Reduction; SARS-CoV-2 exposure; Sampling; Science; Scientist; Self Efficacy; Testing; Training and Education; Universities; Weight; Weight maintenance regimen; Work; acceptability and feasibility; adherence rate; behavior change; comorbidity; comparison control; design; dietary; effective intervention; effectiveness evaluation; efficacy evaluation; exercise intervention; exercise regimen; experience; experimental group; falls; follow-up; functional disability; good diet; health related quality of life; high risk; human old age (65+); improved; innovation; insight; intervention effect; intervention participants; mortality; multiple chronic conditions; muscle form; muscle strength; novel; novel strategies; online delivery; peer; post intervention; prevent; programs; protein intake; randomized trial; recruit; resistance exercise; retention rate; sarcopenia; survivorship; waist circumference

ABSTRACT Accounting for more than 60% of cancer survivors, older (≥65 years) cancer survivors, have a 2- to 5-fold risk of physical function impairment, compared to cancer-free controls. Physical function impairment has multiple deleterious health effects including poor health-related quality of life (HRQoL), multi-morbidity, increased falls, and all-cause mortality. One strategy to improve physical function is dietary and resistance training interventions, which improve muscle strength and mass by stimulating muscle protein synthesis. However, there are no synchronous, online diet and exercise interventions for older cancer survivors, a group at high risk for functional limitations. Thus, the E-PROOF (E-intervention for Protein Intake and Resistance Training to Optimize Function) study will examine the feasibility, acceptability, and preliminary efficacy of a 12-week randomized controlled trial of an online, tailored nutritional and resistance training education and counseling intervention to improve physical function and associated health outcomes (muscle strength, HRQoL, self-efficacy, and weight management). We postulate that, compared to the control group, intervention participants would experience statistically significant, clinically meaningful improvements in physical function and associated health outcomes following the 12-week diet and resistance training intervention. To achieve our objective, we will: 1) Determine the feasibility and acceptability of implementing an online dietary and resistance training intervention among 70 older cancer survivors; and; 2) Examine the preliminary efficacy of an online dietary and resistance training intervention to improve physical function and associated outcomes among 70 older cancer survivors who participated in a 12- week intervention. In this pilot randomized controlled trial, participants will be randomized to one of two groups: one experimental (online counseling by a registered dietitian and exercise scientist, menus, educational materials on protein, healthy diet, resistance training) and one control (general survivorship education). We will examine the intervention effects on physical function, muscle strength, HRQoL, self-efficacy, weight, and waist circumference during a 12-week period between the experimental and control groups. We will conduct a 3-month follow-up to assess physical function, muscle strength, and HRQoL. The feasibility of conducting an online diet and resistance training intervention in older cancer survivors will be determined by the study accrual, retention, and adherence rates. This study will inform the development of a R01 scale randomized controlled trial to evaluate the effectiveness of a protein-focused meal delivery program and resistance exercise regimen on risk for functional impairment and sarcopenia among older cancer survivors. The study goals respond to the NIA and NCI missions to address the research gaps in older cancer survivors and help them lead longer, healthier lives. This novel study advances science by promoting independent health behaviors among older cancer survivors, which can improve health outcomes and provide foundational knowledge to further address this growing problem on a wider scale through online platforms.

摘要