Neuroimaging in Pregnancy to Assess Effects of Opioid Use Disorder
妊娠期神经影像学评估阿片类药物使用障碍的影响
基本信息
- 批准号:10665962
- 负责人:
- 金额:$ 23.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAmericanAnatomyBody WeightBrainBuprenorphineChildChildhoodClinicalCognitiveDataDiffusion Magnetic Resonance ImagingDoseEarly identificationEffectivenessExposure toFunctional Magnetic Resonance ImagingFutureGoalsHealthHumanIndividualInfantKnowledgeMagnetic Resonance ImagingMental DepressionMetabolic PathwayMetabolismMethodsMothersNeonatalNeonatal Abstinence SyndromeNeurobiologyOpioidOpioid replacement therapyOutcomePharmaceutical PreparationsPhysiologicalPlasmaPostpartum PeriodPregnancyPregnancy OutcomePregnant WomenPreventionPsyche structurePublic HealthRelapseResearchResearch PersonnelRestRiskSeveritiesStructureThird Pregnancy TrimesterUp-RegulationVariantWeight GainWithdrawal SymptomWomanadverse outcomeantenatalbehavioral outcomebuprenorphine treatmentcravingdesigndrug relapsedrug withdrawalexperiencefetal opioid exposuregray matterhigh riskimaging biomarkerimprovedindividual variationinfant outcomeinsightmaternal opioid usematernal outcomematernal riskmultimodal neuroimagingneural circuitneurodevelopmentneuroimagingneuroimaging markerneuromechanismnon-opioid analgesicnovelopioid epidemicopioid exposureopioid use disorderoutcome predictionpandemic diseasepolysubstance usepredictive markerpregnantprenatalpreventprognosticprognostic toolrelapse predictionresponserisk minimizationrisk predictiontooltreatment responsewhite matter
项目摘要
Project Summary: Opioid use disorder (OUD) in pregnant American women is a major and growing public
health concern. Despite medication treatment for OUD with buprenorphine, these pregnant women continue to
be at high risk for early relapse, polysubstance use and depression worsening their and their children’s
outcomes. We and other investigators have previously shown altered brain resting state functional MRI (rs-fMRI)
connectivity in infants with prenatal opioid exposure that correlate with outcomes. However, there are no
neuroimaging studies in pregnant women with OUD to understand the neurobiological effects of OUD,
buprenorphine dose response and effects of concomitant polysubstance use in pregnant women. In pregnant
women on buprenorphine OUD, there is variability in dose escalation and requirement to prevent withdrawal
symptoms and craving due to increasing body weight and variable upregulation of buprenorphine metabolic
pathways. Individual variability to buprenorphine metabolism may underlie variations in treatment response and
individual poor neurobiological outcomes including postpartum relapse and depression. Our research is focused
on fulfilling the critical unmet need to better understand the structural and functional brain alterations in
pregnancy that correlate with buprenorphine treatment doses and plasma exposures to optimize maternal OUD
outcomes. The objective of this application is to characterize OUD-related prenatal maternal brain structural and
rs-fMRI alterations, and how buprenorphine treatment influences these alterations identified on neuroimaging.
The specific aims of our project are to assess OUD related alterations in maternal brain structure and rs-fMRI
connectivity in pregnant women and assess the associations of maternal brain structural and rs-fMRI connectivity
alterations with plasma buprenorphine in pregnant women with OUD. This proposal is expected to provide
critical new knowledge on the impact of buprenorphine treatment on maternal brain, and insight into the impact
of individual buprenorphine metabolism upregulation in pregnancy on these brain alterations. Eventually, these
results will help develop maternal neuroimaging as a potential prognostic tool for early identification of maternal
and infant outcomes.
阿片类药物使用障碍(OUD)在美国孕妇是一个主要的和不断增长的公众
健康问题。尽管使用丁丙诺啡对OUD进行药物治疗,但这些孕妇继续
早期复发的风险很高,多种物质的使用和抑郁症恶化了他们和他们的孩子的
结果。我们和其他研究人员先前已经显示了改变的大脑静息状态功能磁共振成像(rs-fMRI)
产前阿片类药物暴露的婴儿的连接与结果相关。但没有
在患有OUD的孕妇中进行神经影像学研究以了解OUD的神经生物学效应,
丁丙诺啡的剂量反应和妊娠妇女合并使用多种药物的影响。妊娠
接受丁丙诺啡OUD的女性,剂量递增和预防停药的要求存在差异
由于体重增加和丁丙诺啡代谢的可变上调引起的症状和渴望
途径。丁丙诺啡代谢的个体差异可能是治疗反应和
个别不良的神经生物学结果,包括产后复发和抑郁症。我们的研究重点是
满足关键的未满足的需求,以更好地了解大脑的结构和功能变化,
妊娠与丁丙诺啡治疗剂量和血浆暴露相关,以优化母体OUD
结果。本申请的目的是表征OUD相关的产前母体脑结构和发育。
rs-fMRI改变,以及丁丙诺啡治疗如何影响神经影像学上确定的这些改变。
我们项目的具体目标是评估OUD相关的母体脑结构改变和rs-fMRI
连接,并评估母体大脑结构和rs-fMRI连接的关联
OUD孕妇血浆丁丙诺啡的变化。预计该提案将提供
关于丁丙诺啡治疗对母体大脑影响的重要新知识,以及对影响的见解
个体丁丙诺啡代谢上调对这些大脑改变的影响。最终这些
结果将有助于发展母体神经影像学作为早期识别母体神经系统疾病的潜在预后工具。
婴儿的结果。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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Rupa Radhakrishnan其他文献
Rupa Radhakrishnan的其他文献
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{{ truncateString('Rupa Radhakrishnan', 18)}}的其他基金
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
阿片类药物使用障碍临床结果的多模态胎儿和胎盘成像和生物标志物
- 批准号:
10750306 - 财政年份:2023
- 资助金额:
$ 23.78万 - 项目类别:
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